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Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk

Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk
Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk
To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 × 10-14), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 × 10-11), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 × 10-9) and 22q13.1 (rs877529, CBX7, P = 7.63 × 10-16). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition.
1061-4036
1221-1225
Chubb, Daniel
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Weinhold, Niels
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Broderick, Peter
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Johnson, David C.
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Försti, Asta
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Vijayakrishnan, Jayaram
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Holroyd, Amy
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Hoffmann, Per
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Nöthen, Markus M.
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Mühleisen, Thomas W.
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Eisele, Lewin
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Ross, Fiona M.
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Straka, Christian
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Einsele, Hermann
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Langer, Christian
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Dörner, Elisabeth
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Houlston, Richard S.
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Goldschmidt, Hartmut
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Chubb, Daniel
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Weinhold, Niels
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Broderick, Peter
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Pratt, Guy
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Fegan, Chris
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Langer, Christian
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Dörner, Elisabeth
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Allan, James M.
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Jauch, Anna
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Morgan, Gareth J.
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Hemminki, Kari
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Houlston, Richard S.
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Goldschmidt, Hartmut
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Chubb, Daniel, Weinhold, Niels, Broderick, Peter, Chen, Bowang, Johnson, David C., Försti, Asta, Vijayakrishnan, Jayaram, Migliorini, Gabriele, Dobbins, Sara E., Holroyd, Amy, Hose, Dirk, Walker, Brian A., Davies, Faith E., Gregory, Walter A., Jackson, Graham H., Irving, Julie A., Pratt, Guy, Fegan, Chris, Fenton, James A.L., Neben, Kai, Hoffmann, Per, Nöthen, Markus M., Mühleisen, Thomas W., Eisele, Lewin, Ross, Fiona M., Straka, Christian, Einsele, Hermann, Langer, Christian, Dörner, Elisabeth, Allan, James M., Jauch, Anna, Morgan, Gareth J., Hemminki, Kari, Houlston, Richard S. and Goldschmidt, Hartmut (2013) Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. Nature Genetics, 45 (10), 1221-1225. (doi:10.1038/ng.2733). (PMID:23955597)

Record type: Article

Abstract

To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 × 10-14), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 × 10-11), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 × 10-9) and 22q13.1 (rs877529, CBX7, P = 7.63 × 10-16). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition.

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e-pub ahead of print date: 18 August 2013
Published date: October 2013
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 356049
URI: http://eprints.soton.ac.uk/id/eprint/356049
ISSN: 1061-4036
PURE UUID: 9f888632-088f-45dc-bcf9-d1660edb514b

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Date deposited: 10 Sep 2013 12:51
Last modified: 22 Jul 2022 18:44

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Contributors

Author: Daniel Chubb
Author: Niels Weinhold
Author: Peter Broderick
Author: Bowang Chen
Author: David C. Johnson
Author: Asta Försti
Author: Jayaram Vijayakrishnan
Author: Gabriele Migliorini
Author: Sara E. Dobbins
Author: Amy Holroyd
Author: Dirk Hose
Author: Brian A. Walker
Author: Faith E. Davies
Author: Walter A. Gregory
Author: Graham H. Jackson
Author: Julie A. Irving
Author: Guy Pratt
Author: Chris Fegan
Author: James A.L. Fenton
Author: Kai Neben
Author: Per Hoffmann
Author: Markus M. Nöthen
Author: Thomas W. Mühleisen
Author: Lewin Eisele
Author: Fiona M. Ross
Author: Christian Straka
Author: Hermann Einsele
Author: Christian Langer
Author: Elisabeth Dörner
Author: James M. Allan
Author: Anna Jauch
Author: Gareth J. Morgan
Author: Kari Hemminki
Author: Richard S. Houlston
Author: Hartmut Goldschmidt

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