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Surface modification of photoresist SU-8 for low autofluorescence and bioanalytical applications

Surface modification of photoresist SU-8 for low autofluorescence and bioanalytical applications
Surface modification of photoresist SU-8 for low autofluorescence and bioanalytical applications
This paper reports a surface modification of epoxy-based negative photoresist SU-8 for reducing its autofluorescence while enhancing its biofunctionality. By covalently depositing a thin layer of 20 nm Au nanoparticles (AuNPs) onto the SU-8 surface, we found that the AuNPs-coated SU-8 surface is much less fluorescent than the untreated SU-8. Moreover, DNA probes can easily be immobilized on the Au surface and are thermally stable over a wide range of temperature. These improvements will benefit bioanalytical applications such as DNA hybridization and solid-phase PCR (SP-PCR).
dna detection, su-8, gold nanoparticles, autofluorescence, photoresist
978-0-9798064-4-5
1161-1163
Cao, C
908fae48-1010-4a1d-9013-578ac4d9e2cf
Birtwell, S.W.
8dca4d3a-2c9e-415c-b9c2-6b3a07bbf5c4
Hogberg, J
dc3bd920-1d1c-47bf-a18f-8ce5e8db9e12
Wolff, A.
5f8a17b8-94e7-46a4-9dfa-9f4644e3f78b
Morgan, H.
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Duobg Bang, D.
a3f44ee9-faf4-438f-8c9a-3c9ad53afb6b
Cao, C
908fae48-1010-4a1d-9013-578ac4d9e2cf
Birtwell, S.W.
8dca4d3a-2c9e-415c-b9c2-6b3a07bbf5c4
Hogberg, J
dc3bd920-1d1c-47bf-a18f-8ce5e8db9e12
Wolff, A.
5f8a17b8-94e7-46a4-9dfa-9f4644e3f78b
Morgan, H.
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Duobg Bang, D.
a3f44ee9-faf4-438f-8c9a-3c9ad53afb6b

Cao, C, Birtwell, S.W., Hogberg, J, Wolff, A., Morgan, H. and Duobg Bang, D. (2011) Surface modification of photoresist SU-8 for low autofluorescence and bioanalytical applications. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, United States. 02 - 06 Oct 2011. pp. 1161-1163 .

Record type: Conference or Workshop Item (Other)

Abstract

This paper reports a surface modification of epoxy-based negative photoresist SU-8 for reducing its autofluorescence while enhancing its biofunctionality. By covalently depositing a thin layer of 20 nm Au nanoparticles (AuNPs) onto the SU-8 surface, we found that the AuNPs-coated SU-8 surface is much less fluorescent than the untreated SU-8. Moreover, DNA probes can easily be immobilized on the Au surface and are thermally stable over a wide range of temperature. These improvements will benefit bioanalytical applications such as DNA hybridization and solid-phase PCR (SP-PCR).

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More information

Published date: October 2011
Venue - Dates: 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, United States, 2011-10-02 - 2011-10-06
Keywords: dna detection, su-8, gold nanoparticles, autofluorescence, photoresist
Organisations: Electronics & Computer Science

Identifiers

Local EPrints ID: 356607
URI: https://eprints.soton.ac.uk/id/eprint/356607
ISBN: 978-0-9798064-4-5
PURE UUID: 84cbe456-594b-4166-9592-79ff64cdde44
ORCID for H. Morgan: ORCID iD orcid.org/0000-0003-4850-5676

Catalogue record

Date deposited: 15 Oct 2013 10:38
Last modified: 06 Jun 2018 12:45

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