Enteric fever in a UK regional infectious diseases unit: a 10 year retrospective review
Enteric fever in a UK regional infectious diseases unit: a 10 year retrospective review
Enteric fever is an increasingly common diagnosis in returning travellers in the UK.
METHODS: We performed a retrospective descriptive study of culture-confirmed cases of enteric fever admitted to University Hospitals Leicester, UK between January 1999 and April 2009.
RESULTS: 100 cases of enteric fever were identified in adults (n = 76) and children (n = 24). The median age of adult subjects was 38 (range 18-71) and 55% were male. Of the 61 adult cases with notes available, 60 (98.3%) were of Asian ethnicity and 56 (92%) had a recent travel history, principally to the Indian Subcontinent. Symptoms included fever (100%), headache (62%), diarrhoea (59%) and abdominal pain (44%). Common examination findings included pyrexia and mild generalized abdominal tenderness. Mild hyponatraemia, transaminitis and a normal white cell count were commonly identified. Reduced ciprofloxacin sensitivity was common and increased over the study period. Median fever clearance time was 6 days, and treatment failure occurred in 20% of cases. Relapse occurred in 2 patients. Complications were unusual, and one patient died.
DISCUSSION: Patients with enteric fever presented with a non-specific febrile illness within one month after returning from travel, and most had an uncomplicated clinical course. Increasing ciprofloxacin insensitivity was the likely explanation for a high treatment failure rate and this agent can no longer recommended as empirical treatment.
typhoid, paratyphoid, returning travellers
91-98
Clark, T.W.
712ec18e-613c-45df-a013-c8a22834e14f
Daneshvar, C.
0f12044a-1c4d-4a9c-9e4a-96df4b6f3b3e
Pareek, M.
19ebd2b3-9d91-4f35-8550-0c3ad6420cc4
Stephenson, I.
cffd5c3c-042f-4902-a2c3-b07b7b79a470
February 2010
Clark, T.W.
712ec18e-613c-45df-a013-c8a22834e14f
Daneshvar, C.
0f12044a-1c4d-4a9c-9e4a-96df4b6f3b3e
Pareek, M.
19ebd2b3-9d91-4f35-8550-0c3ad6420cc4
Stephenson, I.
cffd5c3c-042f-4902-a2c3-b07b7b79a470
Clark, T.W., Daneshvar, C., Pareek, M. and Stephenson, I.
(2010)
Enteric fever in a UK regional infectious diseases unit: a 10 year retrospective review.
Journal of Infection, 60 (2), .
(doi:10.1016/j.jinf.2009.11.009).
(PMID:19962402)
Abstract
Enteric fever is an increasingly common diagnosis in returning travellers in the UK.
METHODS: We performed a retrospective descriptive study of culture-confirmed cases of enteric fever admitted to University Hospitals Leicester, UK between January 1999 and April 2009.
RESULTS: 100 cases of enteric fever were identified in adults (n = 76) and children (n = 24). The median age of adult subjects was 38 (range 18-71) and 55% were male. Of the 61 adult cases with notes available, 60 (98.3%) were of Asian ethnicity and 56 (92%) had a recent travel history, principally to the Indian Subcontinent. Symptoms included fever (100%), headache (62%), diarrhoea (59%) and abdominal pain (44%). Common examination findings included pyrexia and mild generalized abdominal tenderness. Mild hyponatraemia, transaminitis and a normal white cell count were commonly identified. Reduced ciprofloxacin sensitivity was common and increased over the study period. Median fever clearance time was 6 days, and treatment failure occurred in 20% of cases. Relapse occurred in 2 patients. Complications were unusual, and one patient died.
DISCUSSION: Patients with enteric fever presented with a non-specific febrile illness within one month after returning from travel, and most had an uncomplicated clinical course. Increasing ciprofloxacin insensitivity was the likely explanation for a high treatment failure rate and this agent can no longer recommended as empirical treatment.
This record has no associated files available for download.
More information
e-pub ahead of print date: 3 September 2009
Published date: February 2010
Keywords:
typhoid, paratyphoid, returning travellers
Organisations:
Faculty of Medicine
Identifiers
Local EPrints ID: 356776
URI: http://eprints.soton.ac.uk/id/eprint/356776
ISSN: 0163-4453
PURE UUID: 5d7511b9-82a2-4fc0-b293-3a21821d85e5
Catalogue record
Date deposited: 25 Sep 2013 16:02
Last modified: 15 Mar 2024 03:49
Export record
Altmetrics
Contributors
Author:
C. Daneshvar
Author:
M. Pareek
Author:
I. Stephenson
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics