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Fetal malnutrition and long-term outcomes

Fetal malnutrition and long-term outcomes
Fetal malnutrition and long-term outcomes
Epidemiological studies have shown that lower birthweight is associated with a wide range of adverse outcomes in later life, including poorer ‘human capital' (shorter stature, lower cognitive performance), increased risk factors for later disease (higher blood pressure and reduced glucose tolerance, and lung, kidney and immune function), clinical disease (diabetes, coronary heart disease, chronic lung and kidney disease), and increased all-cause and cardiovascular mortality. Higher birthweight is associated with an increased risk of cancer and (if caused by gestational diabetes) obesity and diabetes. The ‘developmental origins of health and disease' hypothesis proposes that fetal nutrition has permanent effects on growth, structure and metabolism (‘programming'). This is supported by studies in animals showing that maternal under- and overnutrition during pregnancy can produce similar abnormalities in the adult offspring. Common chronic diseases could potentially be prevented by achieving optimal fetal nutrition, and this could have additional benefits for survival and human capital. Recent follow-up of children born after randomized nutritional interventions in pregnancy provides weak evidence of beneficial effects on growth, vascular function, lipid concentrations, glucose tolerance and insulin resistance. Animal studies indicate that epigenetic phenomena may be an important mechanism underlying programming, and that nutritional interventions may need to start preconceptionally.

978-3-318-02394-7
11-25
Karger
Fall, C.H.
7171a105-34f5-4131-89d7-1aa639893b18
Bhatia, J.
Bhutta, Z.A.
Kalhan, S.C.
Fall, C.H.
7171a105-34f5-4131-89d7-1aa639893b18
Bhatia, J.
Bhutta, Z.A.
Kalhan, S.C.

Fall, C.H. (2013) Fetal malnutrition and long-term outcomes. Bhatia, J., Bhutta, Z.A. and Kalhan, S.C. (eds.) In Maternal and Child Nutrition: The First 1,000 Days. vol. 74, Karger. pp. 11-25 . (doi:10.1159/000348384).

Record type: Conference or Workshop Item (Paper)

Abstract

Epidemiological studies have shown that lower birthweight is associated with a wide range of adverse outcomes in later life, including poorer ‘human capital' (shorter stature, lower cognitive performance), increased risk factors for later disease (higher blood pressure and reduced glucose tolerance, and lung, kidney and immune function), clinical disease (diabetes, coronary heart disease, chronic lung and kidney disease), and increased all-cause and cardiovascular mortality. Higher birthweight is associated with an increased risk of cancer and (if caused by gestational diabetes) obesity and diabetes. The ‘developmental origins of health and disease' hypothesis proposes that fetal nutrition has permanent effects on growth, structure and metabolism (‘programming'). This is supported by studies in animals showing that maternal under- and overnutrition during pregnancy can produce similar abnormalities in the adult offspring. Common chronic diseases could potentially be prevented by achieving optimal fetal nutrition, and this could have additional benefits for survival and human capital. Recent follow-up of children born after randomized nutritional interventions in pregnancy provides weak evidence of beneficial effects on growth, vascular function, lipid concentrations, glucose tolerance and insulin resistance. Animal studies indicate that epigenetic phenomena may be an important mechanism underlying programming, and that nutritional interventions may need to start preconceptionally.

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More information

Published date: 2013
Venue - Dates: 74th Nestlé Nutrition Institute Workshop, India, 2012-03-11 - 2012-03-14
Organisations: Faculty of Medicine

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Local EPrints ID: 356882
URI: http://eprints.soton.ac.uk/id/eprint/356882
ISBN: 978-3-318-02394-7
PURE UUID: 2e667023-3967-461b-8446-4320e630b8b0

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Date deposited: 23 Sep 2013 11:33
Last modified: 16 Jul 2019 21:23

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Contributors

Author: C.H. Fall
Editor: J. Bhatia
Editor: Z.A. Bhutta
Editor: S.C. Kalhan

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