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What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis?

What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis?
What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis?
Knee osteoarthritis is associated with structural changes in the joint. Despite its many drawbacks, radiography is the current standard for evaluating joint structure in trials of potential disease-modifying osteoarthritis drugs. MRI is a non-invasive alternative that provides comprehensive imaging of the whole joint. Frequently used MRI measurements in knee osteoarthritis are cartilage volume and thickness; others include synovitis, synovial fluid effusions, bone marrow lesions (BML) and meniscal damage. Joint replacement is considered a clinically relevant outcome in knee osteoarthritis; however, its utility in clinical trials is limited. An alternative is virtual knee replacement on the basis of symptoms and structural damage. MRI may prove to be a good alternative to radiography in definitions of knee replacement. One of the MRI parameters that predicts knee replacement is medial compartment cartilage volume/thickness, which correlates with radiographic joint space width, is sensitive to change, and predicts outcomes in a continuous manner. Other MRI parameters include BML and meniscal lesions. MRI appears to be a viable alternative to radiography for the evaluation of structural changes in knee osteoarthritis and prediction of joint replacement.

0003-4967
1594-1604
Pelletier, J.P.
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Cooper, C.
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Peterfy, C.
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Reginster, J.Y.
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Brandi, M.L.
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Bruyere, O.
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Chapurlat, R.
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Cicuttini, F.
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Conaghan, P.G.
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Doherty, M.
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Genant, H.
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Giacovelli, G.
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Hochberg, M.C.
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Hunter, D.J.
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Kanis, J.A.
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Kloppenburg, M.
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Laredo, J.D.
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McAlindon, T.
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Nevitt, M.
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Raynauld, J.P.
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Rizzoli, R.
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Zilkens, C.
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Roemer, F.W.
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Martel-Pelletier, J.
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Guermazi, A.
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Pelletier, J.P.
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Cooper, C.
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Peterfy, C.
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Reginster, J.Y.
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Brandi, M.L.
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Bruyere, O.
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Chapurlat, R.
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Cicuttini, F.
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Conaghan, P.G.
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Doherty, M.
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Genant, H.
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Giacovelli, G.
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Hochberg, M.C.
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Hunter, D.J.
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Kanis, J.A.
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Kloppenburg, M.
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Laredo, J.D.
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McAlindon, T.
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Nevitt, M.
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Raynauld, J.P.
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Rizzoli, R.
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Zilkens, C.
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Roemer, F.W.
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Martel-Pelletier, J.
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Guermazi, A.
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Pelletier, J.P., Cooper, C., Peterfy, C., Reginster, J.Y., Brandi, M.L., Bruyere, O., Chapurlat, R., Cicuttini, F., Conaghan, P.G., Doherty, M., Genant, H., Giacovelli, G., Hochberg, M.C., Hunter, D.J., Kanis, J.A., Kloppenburg, M., Laredo, J.D., McAlindon, T., Nevitt, M., Raynauld, J.P., Rizzoli, R., Zilkens, C., Roemer, F.W., Martel-Pelletier, J. and Guermazi, A. (2013) What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis? Annals of the Rheumatic Diseases, 72 (10), 1594-1604. (doi:10.1136/annrheumdis-2013-203631). (PMID:23887285)

Record type: Article

Abstract

Knee osteoarthritis is associated with structural changes in the joint. Despite its many drawbacks, radiography is the current standard for evaluating joint structure in trials of potential disease-modifying osteoarthritis drugs. MRI is a non-invasive alternative that provides comprehensive imaging of the whole joint. Frequently used MRI measurements in knee osteoarthritis are cartilage volume and thickness; others include synovitis, synovial fluid effusions, bone marrow lesions (BML) and meniscal damage. Joint replacement is considered a clinically relevant outcome in knee osteoarthritis; however, its utility in clinical trials is limited. An alternative is virtual knee replacement on the basis of symptoms and structural damage. MRI may prove to be a good alternative to radiography in definitions of knee replacement. One of the MRI parameters that predicts knee replacement is medial compartment cartilage volume/thickness, which correlates with radiographic joint space width, is sensitive to change, and predicts outcomes in a continuous manner. Other MRI parameters include BML and meniscal lesions. MRI appears to be a viable alternative to radiography for the evaluation of structural changes in knee osteoarthritis and prediction of joint replacement.

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Published date: October 2013
Organisations: Faculty of Medicine

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Local EPrints ID: 356951
URI: http://eprints.soton.ac.uk/id/eprint/356951
ISSN: 0003-4967
PURE UUID: f14d7b81-3f52-4ce9-bbdc-252fc3e02855
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 23 Sep 2013 10:22
Last modified: 03 Dec 2019 01:58

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Contributors

Author: J.P. Pelletier
Author: C. Cooper ORCID iD
Author: C. Peterfy
Author: J.Y. Reginster
Author: M.L. Brandi
Author: O. Bruyere
Author: R. Chapurlat
Author: F. Cicuttini
Author: P.G. Conaghan
Author: M. Doherty
Author: H. Genant
Author: G. Giacovelli
Author: M.C. Hochberg
Author: D.J. Hunter
Author: J.A. Kanis
Author: M. Kloppenburg
Author: J.D. Laredo
Author: T. McAlindon
Author: M. Nevitt
Author: J.P. Raynauld
Author: R. Rizzoli
Author: C. Zilkens
Author: F.W. Roemer
Author: J. Martel-Pelletier
Author: A. Guermazi

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