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Tools in the assessment of sarcopenia

Tools in the assessment of sarcopenia
Tools in the assessment of sarcopenia
Objective We aimed to test the fetal overnutrition hypothesis by comparing the associations of maternal and paternal adiposity (sum of skinfolds) with adiposity and cardiovascular risk factors in children.
Design Children from a prospective birth cohort had anthropometry, fat percentage (bio-impedance), plasma glucose, insulin and lipid concentrations and blood pressure measured at 9·5 years of age. Detailed anthropometric measurements were recorded for mothers (at 30 ± 2 weeks’ gestation) and fathers (5 years following the index pregnancy).
Setting Holdsworth Memorial Hospital, Mysore, India.
Subjects Children (n 504), born to mothers with normal glucose tolerance during pregnancy.
Results Twenty-eight per cent of mothers and 38 % of fathers were overweight/obese (BMI ? 25·0 kg/m2), but only 4 % of the children were overweight/obese (WHO age- and sex-specific BMI ? 18·2 kg/m2). The children's adiposity (BMI, sum of skinfolds, fat percentage and waist circumference), fasting insulin concentration and insulin resistance increased with increasing maternal and paternal sum of skinfolds adjusted for the child's sex, age and socio-economic status. Maternal and paternal effects were similar. The associations with fasting insulin and insulin resistance were attenuated after adjusting for the child's current adiposity.
Conclusions In this population, both maternal and paternal adiposity equally predict adiposity and insulin resistance in the children. This suggests that shared family environment and lifestyle, or genetic/epigenetic factors, influence child adiposity. Our findings do not support the hypothesis that there is an intra-uterine overnutrition effect of maternal adiposity in non-diabetic pregnancies, although we cannot rule out such an effect in cases of extreme maternal obesity, which is rare in our population.
0171-967X
201-210
Cooper, C.
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Fielding, R.
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Visser, M.
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van Loon, L.J.
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Rolland, Y.
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Orwoll, E.
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Reid, K.
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Boonen, S.
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Dere, W.
e2e72664-566b-4db6-863a-9a62e116849c
Epstein, S.
be17be49-6fd1-43f7-8bfd-59a850aaa33f
Tsouderos, Y.
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Sayer, A.A.
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Rizzoli, R.
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Reginster, J.Y.
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Kanis, J.A.
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Mitlak, B.
5bd5363a-768e-4e9c-8662-1a54fb6143df
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Fielding, R.
367db2a0-b6c3-4759-90a4-e61a246757c4
Visser, M.
5b26c37b-3677-4606-9a46-9c06ce3cad8b
van Loon, L.J.
024bbe8a-c2c3-4ee8-a655-d98f4297db6d
Rolland, Y.
2baa5a50-58f6-4527-88d4-3bb20e05f886
Orwoll, E.
0533e322-dc2b-4460-b2c1-6e9b89e35a3a
Reid, K.
5c54fe9d-691a-445d-ab8f-e3e2e7676bb6
Boonen, S.
19c70ece-493f-4b7c-9bf9-5e4a4a887ba4
Dere, W.
e2e72664-566b-4db6-863a-9a62e116849c
Epstein, S.
be17be49-6fd1-43f7-8bfd-59a850aaa33f
Mitlak, B.
5bd5363a-768e-4e9c-8662-1a54fb6143df
Tsouderos, Y.
1cf1fc63-d05f-41de-98f8-01ae38bddfa3
Sayer, A.A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Rizzoli, R.
2214fb77-8fb7-4c0b-bfc4-9f8d3cace5d7
Reginster, J.Y.
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Kanis, J.A.
8da04a36-08a7-4310-b4b4-a6d432439587

Cooper, C., Fielding, R., Visser, M., van Loon, L.J., Rolland, Y., Orwoll, E., Reid, K., Boonen, S., Dere, W., Epstein, S., Tsouderos, Y., Sayer, A.A., Rizzoli, R., Reginster, J.Y. and Kanis, J.A. , Mitlak, B. (ed.) (2013) Tools in the assessment of sarcopenia. Calcified Tissue International, 93 (3), 201-210. (doi:10.1007/s00223-013-9757-z). (PMID:23842964)

Record type: Article

Abstract

Objective We aimed to test the fetal overnutrition hypothesis by comparing the associations of maternal and paternal adiposity (sum of skinfolds) with adiposity and cardiovascular risk factors in children.
Design Children from a prospective birth cohort had anthropometry, fat percentage (bio-impedance), plasma glucose, insulin and lipid concentrations and blood pressure measured at 9·5 years of age. Detailed anthropometric measurements were recorded for mothers (at 30 ± 2 weeks’ gestation) and fathers (5 years following the index pregnancy).
Setting Holdsworth Memorial Hospital, Mysore, India.
Subjects Children (n 504), born to mothers with normal glucose tolerance during pregnancy.
Results Twenty-eight per cent of mothers and 38 % of fathers were overweight/obese (BMI ? 25·0 kg/m2), but only 4 % of the children were overweight/obese (WHO age- and sex-specific BMI ? 18·2 kg/m2). The children's adiposity (BMI, sum of skinfolds, fat percentage and waist circumference), fasting insulin concentration and insulin resistance increased with increasing maternal and paternal sum of skinfolds adjusted for the child's sex, age and socio-economic status. Maternal and paternal effects were similar. The associations with fasting insulin and insulin resistance were attenuated after adjusting for the child's current adiposity.
Conclusions In this population, both maternal and paternal adiposity equally predict adiposity and insulin resistance in the children. This suggests that shared family environment and lifestyle, or genetic/epigenetic factors, influence child adiposity. Our findings do not support the hypothesis that there is an intra-uterine overnutrition effect of maternal adiposity in non-diabetic pregnancies, although we cannot rule out such an effect in cases of extreme maternal obesity, which is rare in our population.

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Published date: September 2013
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 357198
URI: http://eprints.soton.ac.uk/id/eprint/357198
ISSN: 0171-967X
PURE UUID: a0a4a55f-ad54-4479-8dcb-2fe2434b58ec
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 23 Sep 2013 10:30
Last modified: 03 Dec 2019 01:58

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Contributors

Author: C. Cooper ORCID iD
Author: R. Fielding
Author: M. Visser
Author: L.J. van Loon
Author: Y. Rolland
Author: E. Orwoll
Author: K. Reid
Author: S. Boonen
Author: W. Dere
Author: S. Epstein
Editor: B. Mitlak
Author: Y. Tsouderos
Author: A.A. Sayer
Author: R. Rizzoli
Author: J.Y. Reginster
Author: J.A. Kanis

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