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Quality of life in sarcopenia and frailty

Quality of life in sarcopenia and frailty
Quality of life in sarcopenia and frailty
The reduced muscle mass and impaired muscle performance that define sarcopenia in older individuals are associated with increased risk of physical limitation and a variety of chronic diseases. They may also contribute to clinical frailty. A gradual erosion of quality of life (QoL) has been evidenced in these individuals, although much of this research has been done using generic QoL instruments, particularly the SF-36, which may not be ideal in older populations with significant comorbidities. This review and report of an expert meeting presents the current definitions of these geriatric syndromes (sarcopenia and frailty). It then briefly summarizes QoL concepts and specificities in older populations and examines the relevant domains of QoL and what is known concerning QoL decline with these conditions. It calls for a clearer definition of the construct of disability, argues that a disease-specific QoL instrument for sarcopenia/frailty would be an asset for future research, and discusses whether there are available and validated components that could be used to this end and whether the psychometric properties of these instruments are sufficiently tested. It calls also for an approach using utility weighting to provide some cost estimates and suggests that a time trade-off study could be appropriate.
age, aging, muscle weakness, quality of life, malnutrition
0171-967X
Rizzoli, René
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Reginster, Jean-Yves
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Arnal, Jean-François
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Bautmans, Ivan
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Beaudart, Charlotte
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Bischoff-Ferrari, Heike
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Biver, Emmanuel
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Boonen, Steven
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Brandi, Maria-Luisa
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Chines, Arkadi
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Cooper, Cyrus
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Epstein, Sol
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Fielding, Roger A.
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Goodpaster, Bret
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Kanis, John A.
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Kaufman, Jean-Marc
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Laslop, Andrea
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Malafarina, Vincenzo
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Mañas, Leocardio Rodgriguez
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Mitlak, Bruce H.
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Oreffo, Richard O.C.
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Petermans, Jean
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Reid, Kieran
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Rolland, Yyves
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Sayer, Avan Aihie
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Tsouderos, Yannis
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Visser, Marjolein
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Bruyère, Olivier
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Rizzoli, René
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Reginster, Jean-Yves
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Arnal, Jean-François
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Bautmans, Ivan
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Beaudart, Charlotte
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Bischoff-Ferrari, Heike
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Biver, Emmanuel
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Boonen, Steven
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Brandi, Maria-Luisa
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Chines, Arkadi
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Cooper, Cyrus
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Epstein, Sol
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Fielding, Roger A.
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Goodpaster, Bret
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Kanis, John A.
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Kaufman, Jean-Marc
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Laslop, Andrea
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Malafarina, Vincenzo
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Mañas, Leocardio Rodgriguez
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Mitlak, Bruce H.
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Oreffo, Richard O.C.
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Petermans, Jean
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Reid, Kieran
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Rolland, Yyves
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Sayer, Avan Aihie
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Tsouderos, Yannis
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Visser, Marjolein
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Bruyère, Olivier
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Rizzoli, René, Reginster, Jean-Yves, Arnal, Jean-François, Bautmans, Ivan, Beaudart, Charlotte, Bischoff-Ferrari, Heike, Biver, Emmanuel, Boonen, Steven, Brandi, Maria-Luisa, Chines, Arkadi, Cooper, Cyrus, Epstein, Sol, Fielding, Roger A., Goodpaster, Bret, Kanis, John A., Kaufman, Jean-Marc, Laslop, Andrea, Malafarina, Vincenzo, Mañas, Leocardio Rodgriguez, Mitlak, Bruce H., Oreffo, Richard O.C., Petermans, Jean, Reid, Kieran, Rolland, Yyves, Sayer, Avan Aihie, Tsouderos, Yannis, Visser, Marjolein and Bruyère, Olivier (2013) Quality of life in sarcopenia and frailty. Calcified Tissue International, 93 (2). (doi:10.1007/s00223-013-9758-y). (PMID:23828275)

Record type: Article

Abstract

The reduced muscle mass and impaired muscle performance that define sarcopenia in older individuals are associated with increased risk of physical limitation and a variety of chronic diseases. They may also contribute to clinical frailty. A gradual erosion of quality of life (QoL) has been evidenced in these individuals, although much of this research has been done using generic QoL instruments, particularly the SF-36, which may not be ideal in older populations with significant comorbidities. This review and report of an expert meeting presents the current definitions of these geriatric syndromes (sarcopenia and frailty). It then briefly summarizes QoL concepts and specificities in older populations and examines the relevant domains of QoL and what is known concerning QoL decline with these conditions. It calls for a clearer definition of the construct of disability, argues that a disease-specific QoL instrument for sarcopenia/frailty would be an asset for future research, and discusses whether there are available and validated components that could be used to this end and whether the psychometric properties of these instruments are sufficiently tested. It calls also for an approach using utility weighting to provide some cost estimates and suggests that a time trade-off study could be appropriate.

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e-pub ahead of print date: 5 July 2013
Published date: August 2013
Keywords: age, aging, muscle weakness, quality of life, malnutrition
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 357221
URI: http://eprints.soton.ac.uk/id/eprint/357221
ISSN: 0171-967X
PURE UUID: 48343c94-8814-4e57-ae1e-6c7542726d9f
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Richard O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

Catalogue record

Date deposited: 25 Sep 2013 14:12
Last modified: 17 Dec 2019 01:56

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Contributors

Author: René Rizzoli
Author: Jean-Yves Reginster
Author: Jean-François Arnal
Author: Ivan Bautmans
Author: Charlotte Beaudart
Author: Heike Bischoff-Ferrari
Author: Emmanuel Biver
Author: Steven Boonen
Author: Maria-Luisa Brandi
Author: Arkadi Chines
Author: Cyrus Cooper ORCID iD
Author: Sol Epstein
Author: Roger A. Fielding
Author: Bret Goodpaster
Author: John A. Kanis
Author: Jean-Marc Kaufman
Author: Andrea Laslop
Author: Vincenzo Malafarina
Author: Leocardio Rodgriguez Mañas
Author: Bruce H. Mitlak
Author: Jean Petermans
Author: Kieran Reid
Author: Yyves Rolland
Author: Avan Aihie Sayer
Author: Yannis Tsouderos
Author: Marjolein Visser
Author: Olivier Bruyère

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