The University of Southampton
University of Southampton Institutional Repository

Intracortical inhibition and facilitation with unilateral dominant, unilateral nondominant and bilateral movement tasks in left- and right-handed adults

Intracortical inhibition and facilitation with unilateral dominant, unilateral nondominant and bilateral movement tasks in left- and right-handed adults
Intracortical inhibition and facilitation with unilateral dominant, unilateral nondominant and bilateral movement tasks in left- and right-handed adults
Purpose

To investigate intracortical inhibition and facilitation in response to unilateral dominant, nondominant and bilateral biceps activation and short-term upper extremity training in right- and left-handed adults.
Methods

Paired-pulse transcranial magnetic stimulation was used to measure intracortical excitability in motor dominant and nondominant cortices of 26 nondisabled adults. Neural facilitation and inhibition were measured in each hemisphere during unilateral dominant, nondominant and bilateral arm activation and after training in each condition.
Results

No differences were seen between right- and left-handed subjects. Intracortical facilitation and decreased inhibition were seen in each hemisphere with unilateral activation/training of contralateral muscles and bilateral muscle activation/training. Persistent intracortical inhibition was seen in each hemisphere with ipsilateral muscle activation/training. Inhibition was greater in the nondominant hemisphere during dominant hemisphere activation (dominant arm contraction).
Conclusion

Strongly dominant individuals show no difference in intracortical responses given handedness. Intracortical activity with unilateral and bilateral arm activation and short-term training differs based on hemispheric dominance, with the motor dominant hemisphere exerting a larger inhibitory influence over the nondominant hemisphere. Bilateral activation and training have a disinhibitory effect in both dominant and nondominant hemispheres.
motor cortex, neuronal excitability, motor control
0022-510X
96-104
McCombe Waller, Sandy
91ffc714-a088-428d-b92c-9b0d70f286da
Forrester, Larry
f4cb091c-9475-40df-a515-0207765cecf9
Villagra, Federico
81d1f3c5-309e-4154-94d7-0e50f6b788ce
Whitall, Jill
9761aefb-be80-4270-bc1f-0e726399376e
McCombe Waller, Sandy
91ffc714-a088-428d-b92c-9b0d70f286da
Forrester, Larry
f4cb091c-9475-40df-a515-0207765cecf9
Villagra, Federico
81d1f3c5-309e-4154-94d7-0e50f6b788ce
Whitall, Jill
9761aefb-be80-4270-bc1f-0e726399376e

McCombe Waller, Sandy, Forrester, Larry, Villagra, Federico and Whitall, Jill (2008) Intracortical inhibition and facilitation with unilateral dominant, unilateral nondominant and bilateral movement tasks in left- and right-handed adults. Journal of the Neurological Sciences, 269 (1-2), 96-104. (doi:10.1016/j.jns.2007.12.033). (PMID:18336839)

Record type: Article

Abstract

Purpose

To investigate intracortical inhibition and facilitation in response to unilateral dominant, nondominant and bilateral biceps activation and short-term upper extremity training in right- and left-handed adults.
Methods

Paired-pulse transcranial magnetic stimulation was used to measure intracortical excitability in motor dominant and nondominant cortices of 26 nondisabled adults. Neural facilitation and inhibition were measured in each hemisphere during unilateral dominant, nondominant and bilateral arm activation and after training in each condition.
Results

No differences were seen between right- and left-handed subjects. Intracortical facilitation and decreased inhibition were seen in each hemisphere with unilateral activation/training of contralateral muscles and bilateral muscle activation/training. Persistent intracortical inhibition was seen in each hemisphere with ipsilateral muscle activation/training. Inhibition was greater in the nondominant hemisphere during dominant hemisphere activation (dominant arm contraction).
Conclusion

Strongly dominant individuals show no difference in intracortical responses given handedness. Intracortical activity with unilateral and bilateral arm activation and short-term training differs based on hemispheric dominance, with the motor dominant hemisphere exerting a larger inhibitory influence over the nondominant hemisphere. Bilateral activation and training have a disinhibitory effect in both dominant and nondominant hemispheres.

Text
Intracortical inhibition and facilitation with unilateral dominant unilateral.pdf - Version of Record
Restricted to Repository staff only
Request a copy

More information

e-pub ahead of print date: 11 March 2008
Published date: 15 June 2008
Keywords: motor cortex, neuronal excitability, motor control
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 358068
URI: http://eprints.soton.ac.uk/id/eprint/358068
ISSN: 0022-510X
PURE UUID: 6a30c7a4-73c4-4805-9d59-9525933766d6

Catalogue record

Date deposited: 03 Oct 2013 16:12
Last modified: 14 Mar 2024 15:00

Export record

Altmetrics

Contributors

Author: Sandy McCombe Waller
Author: Larry Forrester
Author: Federico Villagra
Author: Jill Whitall

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×