Integrated DNA copy number and methylation profiling of lymphoid neoplasms using a single array
Integrated DNA copy number and methylation profiling of lymphoid neoplasms using a single array
Changes in DNA copy number (CN) and DNA methylation represent important aberrations for lymphomas and other cancers. Here, for the first time, we show that the Illumina Infinium Methylation (IIM) assay, although not originally designed for CN profiling, is able to estimate CN changes. We compared the IIM CN profiles to those obtained with a standard technique in a series of diffuse large B-cell lymphomas: the profiles showed a high degree of consensus. The demonstration of CN profiling as an additional function of the IIM assay may impact the choice of platform for methylation profiling of haematological and solid tumours.
malignant lymphomas, methylation, arrayCGH, illumina infinium methylation
354-357
Kwee, Ivo
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Rinaldi, Andrea
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Rancoita, Paola
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Rossi, Davide
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Capello, Daniela
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Forconi, Francesco
ce9ed873-58cf-4876-bf3a-9ba1d163edc8
Giuliani, Nicola
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Piva, Roberto
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Inghirami, Giorgio
d6810adb-392a-43cd-9ed3-434bb36aa4df
Gaidano, Gianluca
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Zucca, Emanuele
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Bertoni, Francesco
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February 2012
Kwee, Ivo
0926a658-8296-4ba4-9a70-abcf8a1aad96
Rinaldi, Andrea
ae4d2559-25e9-47b8-8c77-308f6cb2a5c4
Rancoita, Paola
4cb5c1d6-577b-4135-bc2a-062624e23c3a
Rossi, Davide
b4b2506d-794c-4c79-8b2d-6767554fd52a
Capello, Daniela
f4d381f4-aaa6-47ae-bebf-53b0aed65055
Forconi, Francesco
ce9ed873-58cf-4876-bf3a-9ba1d163edc8
Giuliani, Nicola
90a1a12f-4c06-424b-96c2-6014ea4a0048
Piva, Roberto
8c544400-2140-43a5-ac32-f3b9343843ea
Inghirami, Giorgio
d6810adb-392a-43cd-9ed3-434bb36aa4df
Gaidano, Gianluca
1a6a7107-107b-4891-82e0-5fedadd2f65a
Zucca, Emanuele
40bd5950-d74e-4169-a2ea-0bfc1058058e
Bertoni, Francesco
13297a2f-854a-4841-a410-d6bfca8afee8
Kwee, Ivo, Rinaldi, Andrea, Rancoita, Paola, Rossi, Davide, Capello, Daniela, Forconi, Francesco, Giuliani, Nicola, Piva, Roberto, Inghirami, Giorgio, Gaidano, Gianluca, Zucca, Emanuele and Bertoni, Francesco
(2012)
Integrated DNA copy number and methylation profiling of lymphoid neoplasms using a single array.
British Journal of Haematology, 156 (3), .
(doi:10.1111/j.1365-2141.2011.08946.x).
(PMID:22118580)
Abstract
Changes in DNA copy number (CN) and DNA methylation represent important aberrations for lymphomas and other cancers. Here, for the first time, we show that the Illumina Infinium Methylation (IIM) assay, although not originally designed for CN profiling, is able to estimate CN changes. We compared the IIM CN profiles to those obtained with a standard technique in a series of diffuse large B-cell lymphomas: the profiles showed a high degree of consensus. The demonstration of CN profiling as an additional function of the IIM assay may impact the choice of platform for methylation profiling of haematological and solid tumours.
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More information
e-pub ahead of print date: 25 November 2011
Published date: February 2012
Keywords:
malignant lymphomas, methylation, arrayCGH, illumina infinium methylation
Organisations:
Cancer Sciences
Identifiers
Local EPrints ID: 358113
URI: http://eprints.soton.ac.uk/id/eprint/358113
ISSN: 0007-1048
PURE UUID: 38322f84-f25d-4635-94f7-dbc23992e180
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Date deposited: 04 Oct 2013 10:50
Last modified: 15 Mar 2024 03:40
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Contributors
Author:
Ivo Kwee
Author:
Andrea Rinaldi
Author:
Paola Rancoita
Author:
Davide Rossi
Author:
Daniela Capello
Author:
Nicola Giuliani
Author:
Roberto Piva
Author:
Giorgio Inghirami
Author:
Gianluca Gaidano
Author:
Emanuele Zucca
Author:
Francesco Bertoni
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