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Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma

Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma
Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma
Antigen stimulation may be important for splenic marginal zone lymphoma pathogenesis. To address this hypothesis, the occurrence of stereotyped B-cell receptors was investigated in 133 SMZL (26 HCV+) compared with 4,414 HCDR3 sequences from public databases. Sixteen SMZL (12%) showed stereotyped BCR; 7 of 86 (8%) SMZL sequences retrieved from public databases also belonged to stereotyped HCDR3 subsets. Three categories of subsets were identified: i) "SMZL-specific subsets" (n=5), composed only of 12 SMZL (9 HCV-from our series); ii) "Non-Hodgkin's lymphoma-like subsets" (n=5), comprising 5 SMZL (4 from our series) clustering with other indolent lymphomas; iii) "CLL-like subsets" (n=6), comprising 6 SMZL (3 from our series) that belonged to known CLL subsets (n=4) or clustered with public CLL sequences. Immunoglobulin 3D modeling of 3 subsets revealed similarities in antigen binding regions not limited to HCDR3. Overall, data suggest that the pathogenesis of splenic marginal zone lymphoma may involve also HCV-unrelated epitopes or an antigenic trigger common to other indolent lymphomas.
splenic marginal zone lymphoma, B cell receptor, immunoglobulin genes, hepatitis C virus
0390-6078
1792-1796
Zibellini, Silvia
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Capello, Daniela
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Forconi, Francesco
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Marcatili, Paolo
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Rossi, Davide
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Rattotti, Sara
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Franceschetti, Silvia
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Sozzi, Elisa
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Cencini, Emanuele
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Marasca, Roberto
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Baldini, Luca
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Tucci, Alessandra
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Bertoni, Francesco
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Passamonti, Francesco
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Orlandi, Ester
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Varettoni, Marzia
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Merli, Michele
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Rizzi, Silvia
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Gattei, Valter
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Tramontano, Anna
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Paulli, Marco
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Gaidano, Gianluca
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Arcaini, Luca
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Zibellini, Silvia
d8c85e2b-7ee1-405f-ab5d-f0b54425d2c5
Capello, Daniela
f4d381f4-aaa6-47ae-bebf-53b0aed65055
Forconi, Francesco
ba40e5ec-24ea-48d5-9a69-c0ffedaf8894
Marcatili, Paolo
bce1edfa-3556-4bf9-a4fe-d9a0cef05f36
Rossi, Davide
b4b2506d-794c-4c79-8b2d-6767554fd52a
Rattotti, Sara
39205401-6042-47d3-972e-244ce47d7432
Franceschetti, Silvia
c159dd93-837d-484f-b29f-1568b423e14a
Sozzi, Elisa
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Cencini, Emanuele
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Marasca, Roberto
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Baldini, Luca
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Tucci, Alessandra
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Bertoni, Francesco
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Passamonti, Francesco
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Orlandi, Ester
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Varettoni, Marzia
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Merli, Michele
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Rizzi, Silvia
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Gattei, Valter
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Tramontano, Anna
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Paulli, Marco
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Gaidano, Gianluca
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Arcaini, Luca
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Zibellini, Silvia, Capello, Daniela, Forconi, Francesco, Marcatili, Paolo, Rossi, Davide, Rattotti, Sara, Franceschetti, Silvia, Sozzi, Elisa, Cencini, Emanuele, Marasca, Roberto, Baldini, Luca, Tucci, Alessandra, Bertoni, Francesco, Passamonti, Francesco, Orlandi, Ester, Varettoni, Marzia, Merli, Michele, Rizzi, Silvia, Gattei, Valter, Tramontano, Anna, Paulli, Marco, Gaidano, Gianluca and Arcaini, Luca (2010) Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma. Haematologica, 95 (10), 1792-1796. (doi:10.3324/haematol.2010.025437). (PMID:20511668)

Record type: Article

Abstract

Antigen stimulation may be important for splenic marginal zone lymphoma pathogenesis. To address this hypothesis, the occurrence of stereotyped B-cell receptors was investigated in 133 SMZL (26 HCV+) compared with 4,414 HCDR3 sequences from public databases. Sixteen SMZL (12%) showed stereotyped BCR; 7 of 86 (8%) SMZL sequences retrieved from public databases also belonged to stereotyped HCDR3 subsets. Three categories of subsets were identified: i) "SMZL-specific subsets" (n=5), composed only of 12 SMZL (9 HCV-from our series); ii) "Non-Hodgkin's lymphoma-like subsets" (n=5), comprising 5 SMZL (4 from our series) clustering with other indolent lymphomas; iii) "CLL-like subsets" (n=6), comprising 6 SMZL (3 from our series) that belonged to known CLL subsets (n=4) or clustered with public CLL sequences. Immunoglobulin 3D modeling of 3 subsets revealed similarities in antigen binding regions not limited to HCDR3. Overall, data suggest that the pathogenesis of splenic marginal zone lymphoma may involve also HCV-unrelated epitopes or an antigenic trigger common to other indolent lymphomas.

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More information

e-pub ahead of print date: 29 May 2010
Published date: 1 October 2010
Keywords: splenic marginal zone lymphoma, B cell receptor, immunoglobulin genes, hepatitis C virus
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 358137
URI: http://eprints.soton.ac.uk/id/eprint/358137
ISSN: 0390-6078
PURE UUID: 053a9065-f03e-42c0-8b9c-6aeccbf1a1a6

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Date deposited: 08 Oct 2013 10:35
Last modified: 14 Mar 2024 15:01

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Contributors

Author: Silvia Zibellini
Author: Daniela Capello
Author: Francesco Forconi
Author: Paolo Marcatili
Author: Davide Rossi
Author: Sara Rattotti
Author: Silvia Franceschetti
Author: Elisa Sozzi
Author: Emanuele Cencini
Author: Roberto Marasca
Author: Luca Baldini
Author: Alessandra Tucci
Author: Francesco Bertoni
Author: Francesco Passamonti
Author: Ester Orlandi
Author: Marzia Varettoni
Author: Michele Merli
Author: Silvia Rizzi
Author: Valter Gattei
Author: Anna Tramontano
Author: Marco Paulli
Author: Gianluca Gaidano
Author: Luca Arcaini

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