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Molecular and clinical features of chronic lymphocytic leukemia with stereotyped B-cell receptors in a Ukrainian cohort

Molecular and clinical features of chronic lymphocytic leukemia with stereotyped B-cell receptors in a Ukrainian cohort
Molecular and clinical features of chronic lymphocytic leukemia with stereotyped B-cell receptors in a Ukrainian cohort
A fraction of chronic lymphocytic leukemia (CLL) carries highly homologous B-cell receptors, characterized by non-random combinations of immunoglobulin heavy-chain variable (IGHV) genes and heavy-chain complementarity-determining region-3 (HCDR3), often associated with a restricted selection of IG(K/L)V light chains. We analyzed the features of CLL expressing homologous HCDR3 in a cohort of 264 Ukrainian patients by merging them with a recently published reference series of 1426 cases. This approach allowed us to identify 96/264 (36%) cases as expressing homologous HCDR3, subdivided into 47 subsets. Among these, 27 apparently novel subsets were identified, although most of them were composed of two sequences per subset ('potential subsets'). CLL cases belonging to several stereotyped subsets showed HCDR3 homologies with various autoreactive clones. Our analysis identified molecular and clinical features of a Ukrainian cohort of patients with CLL.
chronic lymphocytic leukemia, IGHV genes, stereotyped B-cell receptor
1042-8194
822-838
Bilous, Nadiia
b5111525-bf9f-48cb-a019-980b21aefd1f
Bomben, Riccardo
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Dal Bo, Michele
c8e380a6-4ee4-40bb-be29-b4923cc03534
Capello, Daniela
f4d381f4-aaa6-47ae-bebf-53b0aed65055
Forconi, Francesco
ce9ed873-58cf-4876-bf3a-9ba1d163edc8
Laurenti, Luca
23c6052d-80af-4fac-92da-2a495a8cb440
Bertoni, Francesco
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Efremov, Dimitar G.
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Marasca, Roberto
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Del Poeta, Giovanni
ed2857f8-ebfc-4d88-96cd-21423e57738d
Martina, Zoya
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Kryachouk, Iryna
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Dyagil, Iryna
023e3819-dbc7-4bd2-8c2f-df6b03fd2254
Gaidano, Gianluca
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Chumak, Anatoliy
edac0723-9726-49b8-8097-e98a36adec67
Gattei, Valter
df828ae8-1b40-4acb-8908-5a6b3d16cf99
Abramenko, Iryna
7913d740-3f98-4ff9-b33a-dd2908b84e89
Bilous, Nadiia
b5111525-bf9f-48cb-a019-980b21aefd1f
Bomben, Riccardo
2de7f588-50b7-43f6-8bb9-ec0a0896b8e5
Dal Bo, Michele
c8e380a6-4ee4-40bb-be29-b4923cc03534
Capello, Daniela
f4d381f4-aaa6-47ae-bebf-53b0aed65055
Forconi, Francesco
ce9ed873-58cf-4876-bf3a-9ba1d163edc8
Laurenti, Luca
23c6052d-80af-4fac-92da-2a495a8cb440
Bertoni, Francesco
13297a2f-854a-4841-a410-d6bfca8afee8
Efremov, Dimitar G.
0cde33de-b384-4d29-bde5-0832a1409b97
Marasca, Roberto
918148d0-8f99-4a29-8322-1b34f6d7dd00
Del Poeta, Giovanni
ed2857f8-ebfc-4d88-96cd-21423e57738d
Martina, Zoya
22766778-702e-43a5-9965-81ac2cd70acb
Kryachouk, Iryna
7edfb59a-b48e-48a2-86cd-89cd7e82f9f4
Dyagil, Iryna
023e3819-dbc7-4bd2-8c2f-df6b03fd2254
Gaidano, Gianluca
1a6a7107-107b-4891-82e0-5fedadd2f65a
Chumak, Anatoliy
edac0723-9726-49b8-8097-e98a36adec67
Gattei, Valter
df828ae8-1b40-4acb-8908-5a6b3d16cf99
Abramenko, Iryna
7913d740-3f98-4ff9-b33a-dd2908b84e89

Bilous, Nadiia, Bomben, Riccardo, Dal Bo, Michele, Capello, Daniela, Forconi, Francesco, Laurenti, Luca, Bertoni, Francesco, Efremov, Dimitar G., Marasca, Roberto, Del Poeta, Giovanni, Martina, Zoya, Kryachouk, Iryna, Dyagil, Iryna, Gaidano, Gianluca, Chumak, Anatoliy, Gattei, Valter and Abramenko, Iryna (2010) Molecular and clinical features of chronic lymphocytic leukemia with stereotyped B-cell receptors in a Ukrainian cohort. Leukemia and Lymphoma, 51 (5), 822-838. (doi:10.3109/10428191003646002). (PMID:20233059)

Record type: Article

Abstract

A fraction of chronic lymphocytic leukemia (CLL) carries highly homologous B-cell receptors, characterized by non-random combinations of immunoglobulin heavy-chain variable (IGHV) genes and heavy-chain complementarity-determining region-3 (HCDR3), often associated with a restricted selection of IG(K/L)V light chains. We analyzed the features of CLL expressing homologous HCDR3 in a cohort of 264 Ukrainian patients by merging them with a recently published reference series of 1426 cases. This approach allowed us to identify 96/264 (36%) cases as expressing homologous HCDR3, subdivided into 47 subsets. Among these, 27 apparently novel subsets were identified, although most of them were composed of two sequences per subset ('potential subsets'). CLL cases belonging to several stereotyped subsets showed HCDR3 homologies with various autoreactive clones. Our analysis identified molecular and clinical features of a Ukrainian cohort of patients with CLL.

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Published date: May 2010
Keywords: chronic lymphocytic leukemia, IGHV genes, stereotyped B-cell receptor
Organisations: Cancer Sciences

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Local EPrints ID: 358143
URI: https://eprints.soton.ac.uk/id/eprint/358143
ISSN: 1042-8194
PURE UUID: cb453a62-4626-460d-99f2-8a07752be510

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Date deposited: 04 Oct 2013 12:48
Last modified: 16 Jul 2019 21:21

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Contributors

Author: Nadiia Bilous
Author: Riccardo Bomben
Author: Michele Dal Bo
Author: Daniela Capello
Author: Luca Laurenti
Author: Francesco Bertoni
Author: Dimitar G. Efremov
Author: Roberto Marasca
Author: Giovanni Del Poeta
Author: Zoya Martina
Author: Iryna Kryachouk
Author: Iryna Dyagil
Author: Gianluca Gaidano
Author: Anatoliy Chumak
Author: Valter Gattei
Author: Iryna Abramenko

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