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Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion

Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion
Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion
Deletion of 17p (TP53) identifies a rare subset of chronic lymphocytic leukaemia (17p- CLL) with aggressive behaviour. Genome-wide DNA-profiling was performed to investigate 18 patients with 17p- CLL. All cases had multiple copy-number (CN) changes. Among the several recurrent CN changes identified, 8q24.13-q24.1-gain (MYC), 8p-loss (TNFRSF10A/B, also known as TRAIL1/2) and 2p16.1-p14-gain (REL/BCL11A) appeared frequently represented. 8p-loss and 2p16.1-p14-gain also appeared clinically relevant and predicted significant shorter time from diagnosis to treatment (8p-loss) and overall survival (8p-loss and 2p16.1-p14-gain, P < 0.05). These observations document a highly unstable genome in 17p- CLL and suggest that additional genes outside the TP53 locus may be important for tumour behaviour.
chronic lymphocytic leukaemia, 17p13 deletion, tp53, genome-wide dna profile, 250K affymetrix, single nucleotide polymporphysms
0007-1048
532-536
Forconi, Francesco
ce9ed873-58cf-4876-bf3a-9ba1d163edc8
Rinaldi, Andrea
ae4d2559-25e9-47b8-8c77-308f6cb2a5c4
Kwee, Ivo
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Sozzi, Elisa
e811ff23-6fe9-47ec-b052-fe8d34d1e36b
Raspadori, Donatella
185f6866-6d10-4f86-9add-72938cea80b3
Rancoita, Paola M V
01264627-1a88-4e00-8516-0228eeed1dbc
Scandurra, Marta
efda00b6-43e9-4a27-95ec-f35febddf5bb
Rossi, Davide
b4b2506d-794c-4c79-8b2d-6767554fd52a
Deambrogi, Clara
c7d10651-681c-41b9-97b6-bf68f3c1243d
Capello, Daniela
f4d381f4-aaa6-47ae-bebf-53b0aed65055
Zucca, Emanuele
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Marconi, Daniela
e4c5087b-4f40-4eb7-8fa0-794d726ba9ff
Bomben, Riccardo
2de7f588-50b7-43f6-8bb9-ec0a0896b8e5
Gattei, Valter
df828ae8-1b40-4acb-8908-5a6b3d16cf99
Lauria, Francesco
f01f163b-abcb-4aad-b952-f4356692f519
Gaidano, Gianluca
1a6a7107-107b-4891-82e0-5fedadd2f65a
Bertoni, Francesco
13297a2f-854a-4841-a410-d6bfca8afee8
Forconi, Francesco
ce9ed873-58cf-4876-bf3a-9ba1d163edc8
Rinaldi, Andrea
ae4d2559-25e9-47b8-8c77-308f6cb2a5c4
Kwee, Ivo
0926a658-8296-4ba4-9a70-abcf8a1aad96
Sozzi, Elisa
e811ff23-6fe9-47ec-b052-fe8d34d1e36b
Raspadori, Donatella
185f6866-6d10-4f86-9add-72938cea80b3
Rancoita, Paola M V
01264627-1a88-4e00-8516-0228eeed1dbc
Scandurra, Marta
efda00b6-43e9-4a27-95ec-f35febddf5bb
Rossi, Davide
b4b2506d-794c-4c79-8b2d-6767554fd52a
Deambrogi, Clara
c7d10651-681c-41b9-97b6-bf68f3c1243d
Capello, Daniela
f4d381f4-aaa6-47ae-bebf-53b0aed65055
Zucca, Emanuele
40bd5950-d74e-4169-a2ea-0bfc1058058e
Marconi, Daniela
e4c5087b-4f40-4eb7-8fa0-794d726ba9ff
Bomben, Riccardo
2de7f588-50b7-43f6-8bb9-ec0a0896b8e5
Gattei, Valter
df828ae8-1b40-4acb-8908-5a6b3d16cf99
Lauria, Francesco
f01f163b-abcb-4aad-b952-f4356692f519
Gaidano, Gianluca
1a6a7107-107b-4891-82e0-5fedadd2f65a
Bertoni, Francesco
13297a2f-854a-4841-a410-d6bfca8afee8

Forconi, Francesco, Rinaldi, Andrea, Kwee, Ivo, Sozzi, Elisa, Raspadori, Donatella, Rancoita, Paola M V, Scandurra, Marta, Rossi, Davide, Deambrogi, Clara, Capello, Daniela, Zucca, Emanuele, Marconi, Daniela, Bomben, Riccardo, Gattei, Valter, Lauria, Francesco, Gaidano, Gianluca and Bertoni, Francesco (2008) Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion. British Journal of Haematology, 143 (4), 532-536. (doi:10.1111/j.1365-2141.2008.07373.x). (PMID:18752589)

Record type: Article

Abstract

Deletion of 17p (TP53) identifies a rare subset of chronic lymphocytic leukaemia (17p- CLL) with aggressive behaviour. Genome-wide DNA-profiling was performed to investigate 18 patients with 17p- CLL. All cases had multiple copy-number (CN) changes. Among the several recurrent CN changes identified, 8q24.13-q24.1-gain (MYC), 8p-loss (TNFRSF10A/B, also known as TRAIL1/2) and 2p16.1-p14-gain (REL/BCL11A) appeared frequently represented. 8p-loss and 2p16.1-p14-gain also appeared clinically relevant and predicted significant shorter time from diagnosis to treatment (8p-loss) and overall survival (8p-loss and 2p16.1-p14-gain, P < 0.05). These observations document a highly unstable genome in 17p- CLL and suggest that additional genes outside the TP53 locus may be important for tumour behaviour.

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More information

Published date: November 2008
Keywords: chronic lymphocytic leukaemia, 17p13 deletion, tp53, genome-wide dna profile, 250K affymetrix, single nucleotide polymporphysms
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 358158
URI: https://eprints.soton.ac.uk/id/eprint/358158
ISSN: 0007-1048
PURE UUID: cbfd0207-3872-4c4e-a5f2-e1e4ee256a99

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Date deposited: 08 Oct 2013 13:58
Last modified: 16 Jul 2019 21:21

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Contributors

Author: Andrea Rinaldi
Author: Ivo Kwee
Author: Elisa Sozzi
Author: Donatella Raspadori
Author: Paola M V Rancoita
Author: Marta Scandurra
Author: Davide Rossi
Author: Clara Deambrogi
Author: Daniela Capello
Author: Emanuele Zucca
Author: Daniela Marconi
Author: Riccardo Bomben
Author: Valter Gattei
Author: Francesco Lauria
Author: Gianluca Gaidano
Author: Francesco Bertoni

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