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Chromosome 14q32 translocations involving the immunoglobulin heavy chain locus in chronic lymphocytic leukaemia identify a disease subset with poor prognosis.

Chromosome 14q32 translocations involving the immunoglobulin heavy chain locus in chronic lymphocytic leukaemia identify a disease subset with poor prognosis.
Chromosome 14q32 translocations involving the immunoglobulin heavy chain locus in chronic lymphocytic leukaemia identify a disease subset with poor prognosis.
Immunophenotypic studies, fluorescence in situ hybridization (FISH) and conventional karyotyping were used to define the clinicobiological significance of 14q32 translocations involving the immunoglobulin gene locus (14q32/IGH) in 252 chronic lymphocytic leukaemia (CLL) patients. The following regions were studied: 13q14, centromere 12, 6q21; 11q22/ATM; 17p13/TP53, 14q32/IGH. Patients were classified as group 1 (favourable, i.e. 13q-single or normal), group 2 (intermediate risk, i.e. +12, 6q-, 1-2 anomalies), group 3 (unfavourable, i.e. 17p-, 11q-, complex karyotype), or group 4 (14q32/IGH translocation). Endpoints were treatment-free survival (TFS) and overall survival (OS). One hundred and ten patients were included in group 1, 99 in group 2, 25 in group 3 and 18 in group 4. 14q32/IGH translocation partners were identified in eight cases (BCL2 in five cases, BCL11A, CCND3 and CDK6 in one case each). group 4 showed shorter TFS versus groups 2 and 1 (25% patients treated at 2 months vs. 12 (P = 0.02) and 20 months (P = 0.002), respectively) and shorter OS (25% patients dead at 18 months versus 50 (P = 0.0003) and >60 months (P < 0.0001) respectively. The 14q32/IGH translocation maintained prognostic significance at multivariate analysis on TFS (P = 0.025) and OS (P < 0.001), along with advanced stage and CD38+. These findings show that the 14q32/IGH translocation predicts for an unfavourable outcome in CLL and that this cytogenetic subset might be included as a separate entity in a hierarchical cytogenetic classification of CLL
0007-1048
529-537
Cavazzini, Francesco
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Hernandez, Jose Angel
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Gozzetti, Alessandro
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Russo Rossi, Antonella
f703ea28-31ca-4385-9714-688e68600378
De Angeli, Cristiano
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Tiseo, Ruana
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Bardi, Antonella
49edc730-6ca2-40f2-a153-be6fab279771
Tammiso, Elisa
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Crupi, Rosaria
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Lenoci, Maria Pia
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Forconi, Francesco
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Lauria, Francesco
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Marasca, Roberto
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Maffei, Rossana
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Torelli, Giuseppe
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Gonzalez, Marcos
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Martin-Jimenez, Patricia
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Maria Hernandez, Jesus
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Rigolin, Gian Matteo
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Cuneo, Antonio
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Cavazzini, Francesco
9998d143-3eca-47b5-b9b5-a96ce8d00a8c
Hernandez, Jose Angel
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Gozzetti, Alessandro
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Russo Rossi, Antonella
f703ea28-31ca-4385-9714-688e68600378
De Angeli, Cristiano
b4c0a6c2-54a0-456a-a030-de1548557430
Tiseo, Ruana
3c1a8046-7945-40c7-b477-7daebaf913e7
Bardi, Antonella
49edc730-6ca2-40f2-a153-be6fab279771
Tammiso, Elisa
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Crupi, Rosaria
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Lenoci, Maria Pia
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Forconi, Francesco
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Lauria, Francesco
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Marasca, Roberto
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Maffei, Rossana
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Torelli, Giuseppe
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Gonzalez, Marcos
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Martin-Jimenez, Patricia
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Maria Hernandez, Jesus
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Rigolin, Gian Matteo
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Cuneo, Antonio
d88ead48-2932-48f0-82c3-85dbe57d7d63

Cavazzini, Francesco, Hernandez, Jose Angel, Gozzetti, Alessandro, Russo Rossi, Antonella, De Angeli, Cristiano, Tiseo, Ruana, Bardi, Antonella, Tammiso, Elisa, Crupi, Rosaria, Lenoci, Maria Pia, Forconi, Francesco, Lauria, Francesco, Marasca, Roberto, Maffei, Rossana, Torelli, Giuseppe, Gonzalez, Marcos, Martin-Jimenez, Patricia, Maria Hernandez, Jesus, Rigolin, Gian Matteo and Cuneo, Antonio (2008) Chromosome 14q32 translocations involving the immunoglobulin heavy chain locus in chronic lymphocytic leukaemia identify a disease subset with poor prognosis. British Journal of Haematology, 142 (4), 529-537. (doi:10.1111/j.1365-2141.2008.07227.x). (PMID:18547320)

Record type: Article

Abstract

Immunophenotypic studies, fluorescence in situ hybridization (FISH) and conventional karyotyping were used to define the clinicobiological significance of 14q32 translocations involving the immunoglobulin gene locus (14q32/IGH) in 252 chronic lymphocytic leukaemia (CLL) patients. The following regions were studied: 13q14, centromere 12, 6q21; 11q22/ATM; 17p13/TP53, 14q32/IGH. Patients were classified as group 1 (favourable, i.e. 13q-single or normal), group 2 (intermediate risk, i.e. +12, 6q-, 1-2 anomalies), group 3 (unfavourable, i.e. 17p-, 11q-, complex karyotype), or group 4 (14q32/IGH translocation). Endpoints were treatment-free survival (TFS) and overall survival (OS). One hundred and ten patients were included in group 1, 99 in group 2, 25 in group 3 and 18 in group 4. 14q32/IGH translocation partners were identified in eight cases (BCL2 in five cases, BCL11A, CCND3 and CDK6 in one case each). group 4 showed shorter TFS versus groups 2 and 1 (25% patients treated at 2 months vs. 12 (P = 0.02) and 20 months (P = 0.002), respectively) and shorter OS (25% patients dead at 18 months versus 50 (P = 0.0003) and >60 months (P < 0.0001) respectively. The 14q32/IGH translocation maintained prognostic significance at multivariate analysis on TFS (P = 0.025) and OS (P < 0.001), along with advanced stage and CD38+. These findings show that the 14q32/IGH translocation predicts for an unfavourable outcome in CLL and that this cytogenetic subset might be included as a separate entity in a hierarchical cytogenetic classification of CLL

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Published date: August 2008
Organisations: Cancer Sciences

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Local EPrints ID: 358159
URI: https://eprints.soton.ac.uk/id/eprint/358159
ISSN: 0007-1048
PURE UUID: 5ab578dd-c554-47d9-8642-929a766c190e

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Date deposited: 04 Oct 2013 08:29
Last modified: 16 Jul 2019 21:21

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Contributors

Author: Francesco Cavazzini
Author: Jose Angel Hernandez
Author: Alessandro Gozzetti
Author: Antonella Russo Rossi
Author: Cristiano De Angeli
Author: Ruana Tiseo
Author: Antonella Bardi
Author: Elisa Tammiso
Author: Rosaria Crupi
Author: Maria Pia Lenoci
Author: Francesco Lauria
Author: Roberto Marasca
Author: Rossana Maffei
Author: Giuseppe Torelli
Author: Marcos Gonzalez
Author: Patricia Martin-Jimenez
Author: Jesus Maria Hernandez
Author: Gian Matteo Rigolin
Author: Antonio Cuneo

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