Trisomy 12 and t(14;22)(q32;q11) in a patient with B-cell chronic lymphocytic leukemia
Trisomy 12 and t(14;22)(q32;q11) in a patient with B-cell chronic lymphocytic leukemia
Recurrent cytogenetic abnormalities are typically found in about one third of B-cell chronic lymphocytic leukemia patients (B-CLL) by standard cytogenetic analysis and their prognostic relevance is well known. We report a case of a B-CLL patient showing both trisomy 12 and a t(14;22)(q32;q11). Trisomy 12 is often associated with aggressive disease and resistance to chemotherapy, however, our patient is in good health and currently untreated after 7 years, suggesting in this case a relatively good prognosis and a questionable role for translocations involving the 14q32 locus.
405-407
Gozzetti, Alessandro
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Marotta, Giuseppe
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Lenoci, Mariapia
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Crupi, Rosaria
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Tozzuoli, Daniela
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Calabrese, Simona
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Forconi, Francesco
ce9ed873-58cf-4876-bf3a-9ba1d163edc8
Fabbri, Alberto
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Lauria, Francesco
f01f163b-abcb-4aad-b952-f4356692f519
October 2004
Gozzetti, Alessandro
18591c75-cbee-444e-972e-b13dce8340e7
Marotta, Giuseppe
7cfa6aac-457c-4b9c-a279-5988a69706c9
Lenoci, Mariapia
e7a3fdb7-9263-45b1-b627-9d85c349abca
Crupi, Rosaria
86b6c4e0-106c-426b-a1e1-5ec8e2af7797
Tozzuoli, Daniela
3e801708-03e8-4879-8183-97fbb70b79d5
Calabrese, Simona
5ce11bd9-1d55-4200-8d42-016b1a93435b
Forconi, Francesco
ce9ed873-58cf-4876-bf3a-9ba1d163edc8
Fabbri, Alberto
01268e1d-6b5a-44e0-9702-a25caa971f59
Lauria, Francesco
f01f163b-abcb-4aad-b952-f4356692f519
Gozzetti, Alessandro, Marotta, Giuseppe, Lenoci, Mariapia, Crupi, Rosaria, Tozzuoli, Daniela, Calabrese, Simona, Forconi, Francesco, Fabbri, Alberto and Lauria, Francesco
(2004)
Trisomy 12 and t(14;22)(q32;q11) in a patient with B-cell chronic lymphocytic leukemia.
Hematology, 9 (5-6), .
(doi:10.1080/10245330400018490).
(PMID:15763981)
Abstract
Recurrent cytogenetic abnormalities are typically found in about one third of B-cell chronic lymphocytic leukemia patients (B-CLL) by standard cytogenetic analysis and their prognostic relevance is well known. We report a case of a B-CLL patient showing both trisomy 12 and a t(14;22)(q32;q11). Trisomy 12 is often associated with aggressive disease and resistance to chemotherapy, however, our patient is in good health and currently untreated after 7 years, suggesting in this case a relatively good prognosis and a questionable role for translocations involving the 14q32 locus.
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Published date: October 2004
Organisations:
Cancer Sciences
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Local EPrints ID: 358175
URI: http://eprints.soton.ac.uk/id/eprint/358175
ISSN: 1024-5332
PURE UUID: b17249b6-ccdc-4cbe-9d9f-384597e6324a
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Date deposited: 08 Oct 2013 15:25
Last modified: 15 Mar 2024 03:41
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Author:
Alessandro Gozzetti
Author:
Giuseppe Marotta
Author:
Mariapia Lenoci
Author:
Rosaria Crupi
Author:
Daniela Tozzuoli
Author:
Simona Calabrese
Author:
Alberto Fabbri
Author:
Francesco Lauria
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