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Coherent anti-Stokes Raman scattering for label-free biomedical imaging

Coherent anti-Stokes Raman scattering for label-free biomedical imaging
Coherent anti-Stokes Raman scattering for label-free biomedical imaging
Coherent anti-Stokes Raman scattering (CARS) has established itself as an imaging technique capable of providing video-rate imaging of biological specimens through vibrational coherence of endogenous molecules. Current techniques predominantly involve the application of costly, invasive and potentially non-specific dyes or labels for imaging biomolecules. CARS microscopy can however provide a high-resolution and non-invasive alternative for imaging biomolecules of interest without the need for exogenous labels. Here we provide an overview of CARS including the technique and common instrumentation as well as its applications in biomedical imaging. We discuss the major biomedical areas where CARS has been applied such as in evaluating liver disease, progression of atherosclerosis, tumour classification and tracking drug delivery, whilst also assessing the future challenges for clinical translation.
2040-8986
94006
Patel, Imran I.
1217bf39-9ae3-4e4c-8d83-06dfcf2ec523
Steuwe, Christian
a7800895-80a0-4ad0-9583-4322b4964158
Reichelt, Stefanie
3d21ecbf-b2e4-4e7f-9c52-f8104af915f2
Mahajan, Sumeet
b131f40a-479e-4432-b662-19d60d4069e9
Patel, Imran I.
1217bf39-9ae3-4e4c-8d83-06dfcf2ec523
Steuwe, Christian
a7800895-80a0-4ad0-9583-4322b4964158
Reichelt, Stefanie
3d21ecbf-b2e4-4e7f-9c52-f8104af915f2
Mahajan, Sumeet
b131f40a-479e-4432-b662-19d60d4069e9

Patel, Imran I., Steuwe, Christian, Reichelt, Stefanie and Mahajan, Sumeet (2013) Coherent anti-Stokes Raman scattering for label-free biomedical imaging. Journal of Optics, 15 (9), 94006. (doi:10.1088/2040-8978/15/9/094006).

Record type: Article

Abstract

Coherent anti-Stokes Raman scattering (CARS) has established itself as an imaging technique capable of providing video-rate imaging of biological specimens through vibrational coherence of endogenous molecules. Current techniques predominantly involve the application of costly, invasive and potentially non-specific dyes or labels for imaging biomolecules. CARS microscopy can however provide a high-resolution and non-invasive alternative for imaging biomolecules of interest without the need for exogenous labels. Here we provide an overview of CARS including the technique and common instrumentation as well as its applications in biomedical imaging. We discuss the major biomedical areas where CARS has been applied such as in evaluating liver disease, progression of atherosclerosis, tumour classification and tracking drug delivery, whilst also assessing the future challenges for clinical translation.

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Published date: 10 September 2013
Organisations: Institute for Life Sciences, Molecular Diagnostics & Thereputics

Identifiers

Local EPrints ID: 358310
URI: http://eprints.soton.ac.uk/id/eprint/358310
ISSN: 2040-8986
PURE UUID: f15d5f15-c6b4-4ad0-a878-0667ada8bc7f
ORCID for Sumeet Mahajan: ORCID iD orcid.org/0000-0001-8923-6666

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Date deposited: 09 Oct 2013 13:54
Last modified: 26 Nov 2021 02:52

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Contributors

Author: Imran I. Patel
Author: Christian Steuwe
Author: Stefanie Reichelt
Author: Sumeet Mahajan ORCID iD

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