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Gold nanoparticles and fluorescently-labelled DNA as a platform for biological sensing

Gold nanoparticles and fluorescently-labelled DNA as a platform for biological sensing
Gold nanoparticles and fluorescently-labelled DNA as a platform for biological sensing
In the past decade gold nanoparticle-nucleic acid conjugates became progressively
important for biomedical applications. Fluorophores attached to nucleic acid-gold nanoparticle
conjugates have opened up a new era of biological sensing. The most promising advancement
in this field was the invention of the so-called ‘nano-flare’ systems. These systems are
capable of detecting specific endocellular targets such as mRNAs, microRNAs or small
molecules in real time. In this minireview, we discuss the current progress in the field
of DNA-nanoparticles as sensors, their properties, stability, cellular uptake and cytotoxicity.
2040-3364
9503-9510
Heuer-Jungemann, Amelie
19d5a272-0f65-4679-b62b-263fa1806230
Harimech, Pascal
adece226-7bb0-4b9d-8dff-1272066dadca
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7
Heuer-Jungemann, Amelie
19d5a272-0f65-4679-b62b-263fa1806230
Harimech, Pascal
adece226-7bb0-4b9d-8dff-1272066dadca
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7

Heuer-Jungemann, Amelie, Harimech, Pascal, Brown, Tom and Kanaras, Antonios G. (2013) Gold nanoparticles and fluorescently-labelled DNA as a platform for biological sensing. Nanoscale, 5 (20), 9503-9510. (doi:10.1039/c3nr03707j).

Record type: Article

Abstract

In the past decade gold nanoparticle-nucleic acid conjugates became progressively
important for biomedical applications. Fluorophores attached to nucleic acid-gold nanoparticle
conjugates have opened up a new era of biological sensing. The most promising advancement
in this field was the invention of the so-called ‘nano-flare’ systems. These systems are
capable of detecting specific endocellular targets such as mRNAs, microRNAs or small
molecules in real time. In this minireview, we discuss the current progress in the field
of DNA-nanoparticles as sensors, their properties, stability, cellular uptake and cytotoxicity.

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Published date: 26 September 2013
Organisations: Quantum, Light & Matter Group

Identifiers

Local EPrints ID: 358644
URI: https://eprints.soton.ac.uk/id/eprint/358644
ISSN: 2040-3364
PURE UUID: 985f08ec-2cdc-4e3f-acd8-96c228ed9e08
ORCID for Antonios G. Kanaras: ORCID iD orcid.org/0000-0002-9847-6706

Catalogue record

Date deposited: 10 Oct 2013 13:58
Last modified: 20 Jul 2019 00:51

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