Manipulation of in vitro angiogenesis using peptide-coated gold nanoparticles
Manipulation of in vitro angiogenesis using peptide-coated gold nanoparticles
We demonstrate the deliberate activation or inhibition of in vitro angiogenesis using functional peptide coated gold nanoparticles. The peptides, anchored to oligo-ethylene glycol capped gold nanospheres, were designed to selectively interact with cell receptors responsible for activation or inhibition of angiogenesis. The functional particles are shown to influence significantly the extent and morphology of vascular structures, without causing toxicity. Mechanistic studies show that the nanoparticles have the ability to alter the balance between naturally secreted pro- and anti- angiogenic factors, under various biological conditions. Nanoparticle-induced control over angiogenesis opens up new directions in targeted drug delivery and therapy.
5628-5636
Bartczak, Dorota
4d706d11-ee17-4e30-9ba8-1d4b3d878f71
Muskens, Otto L.
2284101a-f9ef-4d79-8951-a6cda5bfc7f9
Sanchez-Elsner, Tilman
b8799f8d-e2b4-4b37-b77c-f2f0e8e2070d
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7
Millar, Timothy M.
ec88510c-ad88-49f6-8b2d-4277c84c1958
June 2013
Bartczak, Dorota
4d706d11-ee17-4e30-9ba8-1d4b3d878f71
Muskens, Otto L.
2284101a-f9ef-4d79-8951-a6cda5bfc7f9
Sanchez-Elsner, Tilman
b8799f8d-e2b4-4b37-b77c-f2f0e8e2070d
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7
Millar, Timothy M.
ec88510c-ad88-49f6-8b2d-4277c84c1958
Bartczak, Dorota, Muskens, Otto L., Sanchez-Elsner, Tilman, Kanaras, Antonios G. and Millar, Timothy M.
(2013)
Manipulation of in vitro angiogenesis using peptide-coated gold nanoparticles.
ACS Nano, 7 (6), .
(doi:10.1021/nn402111z).
Abstract
We demonstrate the deliberate activation or inhibition of in vitro angiogenesis using functional peptide coated gold nanoparticles. The peptides, anchored to oligo-ethylene glycol capped gold nanospheres, were designed to selectively interact with cell receptors responsible for activation or inhibition of angiogenesis. The functional particles are shown to influence significantly the extent and morphology of vascular structures, without causing toxicity. Mechanistic studies show that the nanoparticles have the ability to alter the balance between naturally secreted pro- and anti- angiogenic factors, under various biological conditions. Nanoparticle-induced control over angiogenesis opens up new directions in targeted drug delivery and therapy.
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e-pub ahead of print date: 28 May 2013
Published date: June 2013
Organisations:
Quantum, Light & Matter Group
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Local EPrints ID: 358649
URI: http://eprints.soton.ac.uk/id/eprint/358649
ISSN: 1936-0851
PURE UUID: 44a2f95d-001d-4f9c-804f-026d1a4a6021
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Date deposited: 10 Oct 2013 16:22
Last modified: 15 Mar 2024 03:34
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Author:
Dorota Bartczak
Author:
Timothy M. Millar
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