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Manipulation of in vitro angiogenesis using peptide-coated gold nanoparticles

Manipulation of in vitro angiogenesis using peptide-coated gold nanoparticles
Manipulation of in vitro angiogenesis using peptide-coated gold nanoparticles
We demonstrate the deliberate activation or inhibition of in vitro angiogenesis using functional
peptide coated gold nanoparticles. The peptides, anchored to oligo-ethylene glycol capped gold
nanospheres, were designed to selectively interact with cell receptors responsible for activation
or inhibition of angiogenesis. The functional particles are shown to influence significantly the
extent and morphology of vascular structures, without causing toxicity. Mechanistic studies show
that the nanoparticles have the ability to alter the balance between naturally secreted pro- and
anti- angiogenic factors, under various biological conditions. Nanoparticle-induced control over
angiogenesis opens up new directions in targeted drug delivery and therapy.
1936-0851
5628-5636
Bartczak, Dorota
4d706d11-ee17-4e30-9ba8-1d4b3d878f71
Muskens, Otto L.
2284101a-f9ef-4d79-8951-a6cda5bfc7f9
Sanchez-Elsner, Tilman
b8799f8d-e2b4-4b37-b77c-f2f0e8e2070d
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7
Millar, Timothy M.
ec88510c-ad88-49f6-8b2d-4277c84c1958
Bartczak, Dorota
4d706d11-ee17-4e30-9ba8-1d4b3d878f71
Muskens, Otto L.
2284101a-f9ef-4d79-8951-a6cda5bfc7f9
Sanchez-Elsner, Tilman
b8799f8d-e2b4-4b37-b77c-f2f0e8e2070d
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7
Millar, Timothy M.
ec88510c-ad88-49f6-8b2d-4277c84c1958

Bartczak, Dorota, Muskens, Otto L., Sanchez-Elsner, Tilman, Kanaras, Antonios G. and Millar, Timothy M. (2013) Manipulation of in vitro angiogenesis using peptide-coated gold nanoparticles. ACS Nano, 7 (6), 5628-5636. (doi:10.1021/nn402111z).

Record type: Article

Abstract

We demonstrate the deliberate activation or inhibition of in vitro angiogenesis using functional
peptide coated gold nanoparticles. The peptides, anchored to oligo-ethylene glycol capped gold
nanospheres, were designed to selectively interact with cell receptors responsible for activation
or inhibition of angiogenesis. The functional particles are shown to influence significantly the
extent and morphology of vascular structures, without causing toxicity. Mechanistic studies show
that the nanoparticles have the ability to alter the balance between naturally secreted pro- and
anti- angiogenic factors, under various biological conditions. Nanoparticle-induced control over
angiogenesis opens up new directions in targeted drug delivery and therapy.

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Published date: June 2013
Organisations: Quantum, Light & Matter Group

Identifiers

Local EPrints ID: 358649
URI: https://eprints.soton.ac.uk/id/eprint/358649
ISSN: 1936-0851
PURE UUID: 44a2f95d-001d-4f9c-804f-026d1a4a6021
ORCID for Otto L. Muskens: ORCID iD orcid.org/0000-0003-0693-5504
ORCID for Antonios G. Kanaras: ORCID iD orcid.org/0000-0002-9847-6706
ORCID for Timothy M. Millar: ORCID iD orcid.org/0000-0002-4539-2445

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Date deposited: 10 Oct 2013 16:22
Last modified: 06 Jun 2018 12:39

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