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Detecting growth hormone misuse in athletes

Detecting growth hormone misuse in athletes
Detecting growth hormone misuse in athletes
Athletes have been misusing growth hormone (GH) for its anabolic and metabolic effects since the early 1980s, at least a decade before endocrinologists began to treat adults with GH deficiency. Although there is an ongoing debate about whether GH is performance enhancing, recent studies suggest that GH improves strength and sprint capacity, particularly when combined with anabolic steroids. The detection of GH misuse is challenging because it is an endogenous hormone. Two approaches have been developed to detect GH misuse; the first is based on the measurement of pituitary GH isoforms and the ratio of 22-kDa isoform to total GH. The second is based on the measurement of insulin like growth factor-I (IGF-I) and N-terminal propeptide of type III procollagen (P-III-NP) which increase in a dose-dependent manner in response to GH administration. Both methodologies have been approved by the World Anti-Doping Agency (WADA) and have led to the detection of a number of athletes misusing GH.
2230-8210
18-22
Holt, R.I.G.
d54202e1-fcf6-4a17-a320-9f32d7024393
Holt, R.I.G.
d54202e1-fcf6-4a17-a320-9f32d7024393

Holt, R.I.G. (2013) Detecting growth hormone misuse in athletes. Indian Journal of Endocrinology and Metabolism, 17 (7), supplement 1, 18-22. (doi:10.4103/2230-8210.119494).

Record type: Article

Abstract

Athletes have been misusing growth hormone (GH) for its anabolic and metabolic effects since the early 1980s, at least a decade before endocrinologists began to treat adults with GH deficiency. Although there is an ongoing debate about whether GH is performance enhancing, recent studies suggest that GH improves strength and sprint capacity, particularly when combined with anabolic steroids. The detection of GH misuse is challenging because it is an endogenous hormone. Two approaches have been developed to detect GH misuse; the first is based on the measurement of pituitary GH isoforms and the ratio of 22-kDa isoform to total GH. The second is based on the measurement of insulin like growth factor-I (IGF-I) and N-terminal propeptide of type III procollagen (P-III-NP) which increase in a dose-dependent manner in response to GH administration. Both methodologies have been approved by the World Anti-Doping Agency (WADA) and have led to the detection of a number of athletes misusing GH.

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Published date: 2013
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 358873
URI: http://eprints.soton.ac.uk/id/eprint/358873
ISSN: 2230-8210
PURE UUID: b384a737-fbae-424f-84ee-e92504ad6c1a
ORCID for R.I.G. Holt: ORCID iD orcid.org/0000-0001-8911-6744

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Date deposited: 14 Oct 2013 13:58
Last modified: 28 Oct 2023 01:48

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