The University of Southampton
University of Southampton Institutional Repository

Altered expression of two-pore domain potassium (K2P) channels in cancer

Altered expression of two-pore domain potassium (K2P) channels in cancer
Altered expression of two-pore domain potassium (K2P) channels in cancer
Potassium channels have become a focus in cancer biology as they play roles in cell behaviours associated with cancer progression, including proliferation, migration and apoptosis. Two-pore domain (K2P) potassium channels are background channels which enable the leak of potassium ions from cells. As these channels are open at rest they have a profound effect on cellular membrane potential and subsequently the electrical activity and behaviour of cells in which they are expressed. The K2P family of channels has 15 mammalian members and already 4 members of this family (K2P2.1, K2P3.1, K2P9.1, K2P5.1) have been implicated in cancer. Here we examine the expression of all 15 members of the K2P family of channels in a range of cancer types. This was achieved using the online cancer microarray database, Oncomine (www.oncomine.org). Each gene was examined across 20 cancer types, comparing mRNA expression in cancer to normal tissue. This analysis revealed all but 3 K2P family members (K2P4.1, K2P16.1, K2P18.1) show altered expression in cancer. Overexpression of K2P channels was observed in a range of cancers including breast, leukaemia and lung while more cancers (brain, colorectal, gastrointestinal, kidney, lung, melanoma, oesophageal) showed underexpression of one or more channels. K2P1.1, K2P3.1, K2P12.1, were overexpressed in a range of cancers. While K2P1.1, K2P3.1, K2P5.1, K2P6.1, K2P7.1 and K2P10.1 showed significant underexpression across the cancer types examined. This analysis supports the view that specific K2P channels may play a role in cancer biology. Their altered expression together with their ability to impact the function of other ion channels and their sensitivity to environmental stimuli (pO2, pH, glucose, stretch) makes understanding the role these channels play in cancer of key importance.
1932-6203
1-11
Williams, Sarah
f98f47db-b1d6-42c2-b0eb-7c0cb9a981d0
Bateman, Andrew
a851558d-8b9b-4020-b148-a239c2b26815
O'Kelly, Ita
e640f28a-42f0-48a6-9ce2-cb5a85d08c66
Williams, Sarah
f98f47db-b1d6-42c2-b0eb-7c0cb9a981d0
Bateman, Andrew
a851558d-8b9b-4020-b148-a239c2b26815
O'Kelly, Ita
e640f28a-42f0-48a6-9ce2-cb5a85d08c66

Williams, Sarah, Bateman, Andrew and O'Kelly, Ita (2013) Altered expression of two-pore domain potassium (K2P) channels in cancer. PLoS ONE, 8 (10), 1-11. (doi:10.1371/journal.pone.0074589).

Record type: Article

Abstract

Potassium channels have become a focus in cancer biology as they play roles in cell behaviours associated with cancer progression, including proliferation, migration and apoptosis. Two-pore domain (K2P) potassium channels are background channels which enable the leak of potassium ions from cells. As these channels are open at rest they have a profound effect on cellular membrane potential and subsequently the electrical activity and behaviour of cells in which they are expressed. The K2P family of channels has 15 mammalian members and already 4 members of this family (K2P2.1, K2P3.1, K2P9.1, K2P5.1) have been implicated in cancer. Here we examine the expression of all 15 members of the K2P family of channels in a range of cancer types. This was achieved using the online cancer microarray database, Oncomine (www.oncomine.org). Each gene was examined across 20 cancer types, comparing mRNA expression in cancer to normal tissue. This analysis revealed all but 3 K2P family members (K2P4.1, K2P16.1, K2P18.1) show altered expression in cancer. Overexpression of K2P channels was observed in a range of cancers including breast, leukaemia and lung while more cancers (brain, colorectal, gastrointestinal, kidney, lung, melanoma, oesophageal) showed underexpression of one or more channels. K2P1.1, K2P3.1, K2P12.1, were overexpressed in a range of cancers. While K2P1.1, K2P3.1, K2P5.1, K2P6.1, K2P7.1 and K2P10.1 showed significant underexpression across the cancer types examined. This analysis supports the view that specific K2P channels may play a role in cancer biology. Their altered expression together with their ability to impact the function of other ion channels and their sensitivity to environmental stimuli (pO2, pH, glucose, stretch) makes understanding the role these channels play in cancer of key importance.

Other
fetchObject.action_uri=info_doi%2F10.1371%2Fjournal.pone.0074589&representation=PDF - Version of Record
Available under License Other.
Download (290kB)

More information

Published date: 7 October 2013
Organisations: Cancer Sciences, Human Development & Health

Identifiers

Local EPrints ID: 358957
URI: http://eprints.soton.ac.uk/id/eprint/358957
ISSN: 1932-6203
PURE UUID: 9077fa59-87b4-4a72-9a87-51bac444bbf7

Catalogue record

Date deposited: 16 Oct 2013 10:44
Last modified: 27 Oct 2023 03:40

Export record

Altmetrics

Contributors

Author: Sarah Williams
Author: Andrew Bateman
Author: Ita O'Kelly

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×