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Monitoring immune modulation by nutrition in the general population: identifying and substantiating effects on human health

Monitoring immune modulation by nutrition in the general population: identifying and substantiating effects on human health
Monitoring immune modulation by nutrition in the general population: identifying and substantiating effects on human health
Optimal functioning of the immune system is crucial to human health, and nutrition is one of the major exogenous factors modulating different aspects of immune function. Currently, no single marker is available to predict the effect of a dietary intervention on different aspects of immune function. To provide further guidance on the assessment and interpretation of the modulation of immune functions due to nutrition in the general population, International Life Sciences Institute Europe commissioned a group of experts from academia, government and the food industry to prepare a guidance document. A draft of this paper was refined at a workshop involving additional experts. First, the expert group defined criteria to evaluate the usefulness of immune function markers. Over seventy-five markers were scored within the context of three distinct immune system functions: defence against pathogens; avoidance or mitigation of allergy; control of low-grade (metabolic) inflammation. The most useful markers were subsequently classified depending on whether they by themselves signify clinical relevance and/or involvement of immune function. Next, five theoretical scenarios were drafted describing potential changes in the values of markers compared with a relevant reference range. Finally, all elements were combined, providing a framework to aid the design and interpretation of studies assessing the effects of nutrition on immune function. This stepwise approach offers a clear rationale for selecting markers for future trials and provides a framework for the interpretation of outcomes. A similar stepwise approach may also be useful to rationalise the selection and interpretation of markers for other physiological processes critical to the maintenance of health and well-being.
biomarkers, immune function, validation, guidance, criteria
0007-1145
S1-S30
Albers, R.
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Bourdet-Sicard, R.
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Braun, D.
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Calder, P.C.
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Herz, U.
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Lambert, C.
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Lenoir-Wijnkoop, I.
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Méheust, A.
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Ouwehand, A.
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Phothirath, P.
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Sako, T.
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Salminen, S.
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Siemensma, A.
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van Loveren, H.
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Sack, U.
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Albers, R.
63eb3d3b-2052-4ad1-a7aa-888a6781c5e0
Bourdet-Sicard, R.
a26da4a1-1c23-4a26-b16a-0947513c962d
Braun, D.
a1b3919e-dc91-4447-8fa4-1c5434572b96
Calder, P.C.
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Herz, U.
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Lambert, C.
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Lenoir-Wijnkoop, I.
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Méheust, A.
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Ouwehand, A.
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Phothirath, P.
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Sako, T.
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Salminen, S.
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Siemensma, A.
d81007fd-238c-4f8f-b341-189d31386604
van Loveren, H.
84034622-3065-4323-948f-037f4471a32f
Sack, U.
a3bc034f-0426-4481-b9d4-c4b9f6f0b51a

Albers, R., Bourdet-Sicard, R., Braun, D., Calder, P.C., Herz, U., Lambert, C., Lenoir-Wijnkoop, I., Méheust, A., Ouwehand, A., Phothirath, P., Sako, T., Salminen, S., Siemensma, A., van Loveren, H. and Sack, U. (2013) Monitoring immune modulation by nutrition in the general population: identifying and substantiating effects on human health. British Journal of Nutrition, 110, supplement 2, S1-S30. (doi:10.1017/S0007114513001505). (PMID:23902657)

Record type: Article

Abstract

Optimal functioning of the immune system is crucial to human health, and nutrition is one of the major exogenous factors modulating different aspects of immune function. Currently, no single marker is available to predict the effect of a dietary intervention on different aspects of immune function. To provide further guidance on the assessment and interpretation of the modulation of immune functions due to nutrition in the general population, International Life Sciences Institute Europe commissioned a group of experts from academia, government and the food industry to prepare a guidance document. A draft of this paper was refined at a workshop involving additional experts. First, the expert group defined criteria to evaluate the usefulness of immune function markers. Over seventy-five markers were scored within the context of three distinct immune system functions: defence against pathogens; avoidance or mitigation of allergy; control of low-grade (metabolic) inflammation. The most useful markers were subsequently classified depending on whether they by themselves signify clinical relevance and/or involvement of immune function. Next, five theoretical scenarios were drafted describing potential changes in the values of markers compared with a relevant reference range. Finally, all elements were combined, providing a framework to aid the design and interpretation of studies assessing the effects of nutrition on immune function. This stepwise approach offers a clear rationale for selecting markers for future trials and provides a framework for the interpretation of outcomes. A similar stepwise approach may also be useful to rationalise the selection and interpretation of markers for other physiological processes critical to the maintenance of health and well-being.

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More information

Published date: August 2013
Keywords: biomarkers, immune function, validation, guidance, criteria
Organisations: Human Development & Health

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Local EPrints ID: 359000
URI: https://eprints.soton.ac.uk/id/eprint/359000
ISSN: 0007-1145
PURE UUID: f40b67b7-84fc-43c0-9d63-47e2f8cee1ab

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Date deposited: 18 Oct 2013 09:21
Last modified: 16 Jul 2019 21:19

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Contributors

Author: R. Albers
Author: R. Bourdet-Sicard
Author: D. Braun
Author: P.C. Calder
Author: U. Herz
Author: C. Lambert
Author: I. Lenoir-Wijnkoop
Author: A. Méheust
Author: A. Ouwehand
Author: P. Phothirath
Author: T. Sako
Author: S. Salminen
Author: A. Siemensma
Author: H. van Loveren
Author: U. Sack

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