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Limited impact of 2 g/day omega-3 fatty acid ethyl esters (Omacor®) on plasma lipids and inflammatory markers in patients awaiting carotid endarterectomy

Limited impact of 2 g/day omega-3 fatty acid ethyl esters (Omacor®) on plasma lipids and inflammatory markers in patients awaiting carotid endarterectomy
Limited impact of 2 g/day omega-3 fatty acid ethyl esters (Omacor®) on plasma lipids and inflammatory markers in patients awaiting carotid endarterectomy
The objective of this study was to determine the effects of prescription omega-3 (n-3) fatty acid ethyl esters (Omacor®) on blood pressure, plasma lipids, and inflammatory marker concentrations in patients awaiting carotid endarterectomy. Patients awaiting carotid endarterectomy (n = 121) were randomised to Omacor® or olive oil as placebo (2 g/day) until surgery (median 21 days). Blood pressure, plasma lipids, and plasma inflammatory markers were determined. There were significant decreases in systolic and diastolic blood pressure and in plasma triglyceride, total cholesterol, low density lipoprotein-cholesterol, soluble vascular cellular adhesion molecule 1, and matrix metalloproteinase 2 concentrations, in both groups. The extent of triglyceride lowering was greater with Omacor® (25%) compared with placebo (9%). Soluble E-selectin concentration was significantly decreased in the Omacor® group but increased in the placebo group. At the end of the supplementation period there were no differences in blood pressure or in plasma lipid and inflammatory marker concentrations between the two groups. It is concluded that Omacor® given at 2 g/day for an average of 21 days to patients with advanced carotid atherosclerosis lowers triglycerides and soluble E-selectin concentrations, but has limited broad impact on the plasma lipid profile or on inflammatory markers. This may be because the duration of intervention was too short or the dose of n-3 fatty acids was too low
1660-3397
3569-3581
Yusof, H.
b5367c5f-33d4-41a2-be40-dc7484b7dd76
Cawood, A.
84f6162a-e00d-497c-86b4-34dc3f70beb8
Ding, R.
f95f4932-79f8-4407-89fc-ccffd9fa38b8
Williams, J.
2ab33bc3-4988-493b-9cd5-ac68d28385cb
Napper, F.
78411d14-502a-4482-80bd-282c325ea7f8
Shearman, C.P.
cf4d6317-f54d-4ab3-ba49-c6797897bbcf
Grimble, R.F.
3100e4d2-8f29-4ca6-a95d-38a6a764865f
Payne, S.
72967c33-d094-4fbe-9ac5-1d60087fb0e7
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Yusof, H.
b5367c5f-33d4-41a2-be40-dc7484b7dd76
Cawood, A.
84f6162a-e00d-497c-86b4-34dc3f70beb8
Ding, R.
f95f4932-79f8-4407-89fc-ccffd9fa38b8
Williams, J.
2ab33bc3-4988-493b-9cd5-ac68d28385cb
Napper, F.
78411d14-502a-4482-80bd-282c325ea7f8
Shearman, C.P.
cf4d6317-f54d-4ab3-ba49-c6797897bbcf
Grimble, R.F.
3100e4d2-8f29-4ca6-a95d-38a6a764865f
Payne, S.
72967c33-d094-4fbe-9ac5-1d60087fb0e7
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6

Yusof, H., Cawood, A., Ding, R., Williams, J., Napper, F., Shearman, C.P., Grimble, R.F., Payne, S. and Calder, P.C. (2013) Limited impact of 2 g/day omega-3 fatty acid ethyl esters (Omacor®) on plasma lipids and inflammatory markers in patients awaiting carotid endarterectomy. Marine Drugs, 11 (9), 3569-3581. (doi:10.3390/md11093569). (PMID:24065166)

Record type: Article

Abstract

The objective of this study was to determine the effects of prescription omega-3 (n-3) fatty acid ethyl esters (Omacor®) on blood pressure, plasma lipids, and inflammatory marker concentrations in patients awaiting carotid endarterectomy. Patients awaiting carotid endarterectomy (n = 121) were randomised to Omacor® or olive oil as placebo (2 g/day) until surgery (median 21 days). Blood pressure, plasma lipids, and plasma inflammatory markers were determined. There were significant decreases in systolic and diastolic blood pressure and in plasma triglyceride, total cholesterol, low density lipoprotein-cholesterol, soluble vascular cellular adhesion molecule 1, and matrix metalloproteinase 2 concentrations, in both groups. The extent of triglyceride lowering was greater with Omacor® (25%) compared with placebo (9%). Soluble E-selectin concentration was significantly decreased in the Omacor® group but increased in the placebo group. At the end of the supplementation period there were no differences in blood pressure or in plasma lipid and inflammatory marker concentrations between the two groups. It is concluded that Omacor® given at 2 g/day for an average of 21 days to patients with advanced carotid atherosclerosis lowers triglycerides and soluble E-selectin concentrations, but has limited broad impact on the plasma lipid profile or on inflammatory markers. This may be because the duration of intervention was too short or the dose of n-3 fatty acids was too low

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Published date: 20 September 2013
Organisations: Human Development & Health

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Local EPrints ID: 359029
URI: http://eprints.soton.ac.uk/id/eprint/359029
ISSN: 1660-3397
PURE UUID: f2121c76-ba51-45b4-9b65-5a96e7cd824d
ORCID for P.C. Calder: ORCID iD orcid.org/0000-0002-6038-710X

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Date deposited: 18 Oct 2013 13:51
Last modified: 09 Jan 2022 02:49

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Contributors

Author: H. Yusof
Author: A. Cawood
Author: R. Ding
Author: J. Williams
Author: F. Napper
Author: C.P. Shearman
Author: R.F. Grimble
Author: S. Payne
Author: P.C. Calder ORCID iD

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