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Clinico-pathological features of postural hypotension in diabetic autonomic neuropathy

Clinico-pathological features of postural hypotension in diabetic autonomic neuropathy
Clinico-pathological features of postural hypotension in diabetic autonomic neuropathy
We report the clinico-pathological features and management of a 49-year-old male with a 30-year history of Type 1 diabetes mellitus who had nephropathy (proteinuria 1.81 g/24 h, creatinine 136 micromol/l), proliferative retinopathy and severe somatic and autonomic neuropathy. A sural nerve biopsy demonstrated marked myelinated fibre loss with unmyelinated fibre degeneration and regeneration combined with extensive endoneurial microangiopathy. The management of the patient's blood pressure problems (supine hypertension) and symptomatic postural hypotension is discussed.
autonomic, capillary, diabetes, nerve fibre, neuropathy, postural hypotension
0742-3071
163-166
Khawaja, K.I.
893d9930-2275-48ad-b21a-80b71d57e888
Walker, D.
b94e6f46-ec02-4b5b-a726-67c0aafc9f94
Hayat, S.A.
43d75043-333f-484f-bc6b-b05a8a5835e0
Boulton, A.J.M.
dbc9bc0c-b82c-4667-9bec-128c4a1a849c
Malik, R.A.
c56a96ae-3ef3-40ba-b86d-9007709d9959
Khawaja, K.I.
893d9930-2275-48ad-b21a-80b71d57e888
Walker, D.
b94e6f46-ec02-4b5b-a726-67c0aafc9f94
Hayat, S.A.
43d75043-333f-484f-bc6b-b05a8a5835e0
Boulton, A.J.M.
dbc9bc0c-b82c-4667-9bec-128c4a1a849c
Malik, R.A.
c56a96ae-3ef3-40ba-b86d-9007709d9959

Khawaja, K.I., Walker, D., Hayat, S.A., Boulton, A.J.M. and Malik, R.A. (2000) Clinico-pathological features of postural hypotension in diabetic autonomic neuropathy. Diabetic Medicine, 17 (2), 163-166. (doi:10.1046/j.1464-5491.2000.00238.x). (PMID:10746489)

Record type: Article

Abstract

We report the clinico-pathological features and management of a 49-year-old male with a 30-year history of Type 1 diabetes mellitus who had nephropathy (proteinuria 1.81 g/24 h, creatinine 136 micromol/l), proliferative retinopathy and severe somatic and autonomic neuropathy. A sural nerve biopsy demonstrated marked myelinated fibre loss with unmyelinated fibre degeneration and regeneration combined with extensive endoneurial microangiopathy. The management of the patient's blood pressure problems (supine hypertension) and symptomatic postural hypotension is discussed.

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Published date: February 2000
Keywords: autonomic, capillary, diabetes, nerve fibre, neuropathy, postural hypotension
Organisations: Medical Education

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Local EPrints ID: 359183
URI: http://eprints.soton.ac.uk/id/eprint/359183
ISSN: 0742-3071
PURE UUID: 411cce92-a9c3-4f65-aeba-fc041b75bc7e

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Date deposited: 23 Oct 2013 11:11
Last modified: 16 Jul 2019 21:18

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Contributors

Author: K.I. Khawaja
Author: D. Walker
Author: S.A. Hayat
Author: A.J.M. Boulton
Author: R.A. Malik

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