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Perineurial abnormalities in the spontaneously diabetic dog

Perineurial abnormalities in the spontaneously diabetic dog
Perineurial abnormalities in the spontaneously diabetic dog
Structural abnormalities of the perineurium from six spontaneously diabetic dogs (diabetes duration 4-8 years and six control animals were quantified using detailed electron microscopic morphometric methods on superficial peroneal nerve biopsy specimens. Total perineurial sheath thickness (microm) was significantly increased in diabetic (8.8+/-0.6) compared to control animals (6.2+/-0.3) (P < 0.02). This was attributed to a significant increase in the mean perineurial lamellar width in diabetic (0.49+/-0.03) compared to control (0.40+/-0.01) (P < 0.04) animals. The number of lamellae also showed a non-significant increase in diabetic animals (7.8+/-0.4) compared to controls (6.9+/-0.13) (P < 0.06). There was no change in the mean interlamellar space in diabetic (0.7+/-0.05) compared to control (0.6+/-0.06) (P = 0.15) animals. The total interlamellar space was increased in diabetic (5.7+/-0.5) compared to control (4.1+/-0.36) (P < 0.04) animals. The perineurial cell basement membrane thickness (nm) was significantly increased in diabetic (126.9+/-9.8) compared to control (62.8+/-6.1) (P < 0.005) animals. The current study has demonstrated significant abnormalities of the perineurium in the spontaneously diabetic dog, which may have relevance to the pathogenesis of diabetic neuropathy.
spontaneous diabetes, peripheral neuropathy, perineurium, morphometry
0001-6322
98-102
Ghani, M.
d0b4b0bf-7b0c-4109-804b-a8b8b5474aa1
Malik, R.A.
c56a96ae-3ef3-40ba-b86d-9007709d9959
Walker, D.
b94e6f46-ec02-4b5b-a726-67c0aafc9f94
Sharma, A.K.
cc76926e-ecc6-4c90-b2fc-3788224c07c5
Lowrie, C.T.
7042e1fa-924f-45ee-ad03-9879cea651e5
Schall, W.D.
876259e3-56ad-4c1f-90f1-7b3235b16931
Boulton, A.J.M.
dbc9bc0c-b82c-4667-9bec-128c4a1a849c
Ghani, M.
d0b4b0bf-7b0c-4109-804b-a8b8b5474aa1
Malik, R.A.
c56a96ae-3ef3-40ba-b86d-9007709d9959
Walker, D.
b94e6f46-ec02-4b5b-a726-67c0aafc9f94
Sharma, A.K.
cc76926e-ecc6-4c90-b2fc-3788224c07c5
Lowrie, C.T.
7042e1fa-924f-45ee-ad03-9879cea651e5
Schall, W.D.
876259e3-56ad-4c1f-90f1-7b3235b16931
Boulton, A.J.M.
dbc9bc0c-b82c-4667-9bec-128c4a1a849c

Ghani, M., Malik, R.A., Walker, D., Sharma, A.K., Lowrie, C.T., Schall, W.D. and Boulton, A.J.M. (1999) Perineurial abnormalities in the spontaneously diabetic dog. Acta Neuropathologica, 97 (1), 98-102. (doi:10.1007/s004010050961). (PMID:9930901)

Record type: Article

Abstract

Structural abnormalities of the perineurium from six spontaneously diabetic dogs (diabetes duration 4-8 years and six control animals were quantified using detailed electron microscopic morphometric methods on superficial peroneal nerve biopsy specimens. Total perineurial sheath thickness (microm) was significantly increased in diabetic (8.8+/-0.6) compared to control animals (6.2+/-0.3) (P < 0.02). This was attributed to a significant increase in the mean perineurial lamellar width in diabetic (0.49+/-0.03) compared to control (0.40+/-0.01) (P < 0.04) animals. The number of lamellae also showed a non-significant increase in diabetic animals (7.8+/-0.4) compared to controls (6.9+/-0.13) (P < 0.06). There was no change in the mean interlamellar space in diabetic (0.7+/-0.05) compared to control (0.6+/-0.06) (P = 0.15) animals. The total interlamellar space was increased in diabetic (5.7+/-0.5) compared to control (4.1+/-0.36) (P < 0.04) animals. The perineurial cell basement membrane thickness (nm) was significantly increased in diabetic (126.9+/-9.8) compared to control (62.8+/-6.1) (P < 0.005) animals. The current study has demonstrated significant abnormalities of the perineurium in the spontaneously diabetic dog, which may have relevance to the pathogenesis of diabetic neuropathy.

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More information

Published date: January 1999
Keywords: spontaneous diabetes, peripheral neuropathy, perineurium, morphometry
Organisations: Medical Education

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Local EPrints ID: 359202
URI: http://eprints.soton.ac.uk/id/eprint/359202
ISSN: 0001-6322
PURE UUID: eebf57eb-2e0a-4586-bd7b-28398b078a9b

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Date deposited: 23 Oct 2013 12:05
Last modified: 16 Jul 2019 21:18

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Contributors

Author: M. Ghani
Author: R.A. Malik
Author: D. Walker
Author: A.K. Sharma
Author: C.T. Lowrie
Author: W.D. Schall
Author: A.J.M. Boulton

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