Administration of AS03B-adjuvanted A(H1N1)pdm09 vaccine in children under 3 years enhances antibody response to H3 and B viruses following a single dose of trivalent vaccine one year later
Administration of AS03B-adjuvanted A(H1N1)pdm09 vaccine in children under 3 years enhances antibody response to H3 and B viruses following a single dose of trivalent vaccine one year later
Background: We report a follow up clinical and serological investigation of 274 children receiving seasonal influenza vaccine (TIV) one year after receipt of either AS03B-adjuvanted subunit or whole virus monovalent A(H1N1)pdm09 vaccine and describe the antibody responses to the H3N2 A/Perth/16/2009 and B/Brisbane/60/2008 components of TIV.
Method and Findings: Vaccine responses were analysed using Haemagglutination Inhibition (HAI) assays. In individuals under 3 years of age, previous receipt of adjuvanted vaccine resulted in higher HAI antibody responses to H3N2 and B strains compared to non-adjuvanted vaccine (fold change 16.8 vs 4.3 for H3N2 and 7.0 vs 1.6 for B). In older children, responses to the H3 and B components of TIV were similar between vaccine groups. Sera taken pre- and post pandemic vaccine were also analysed by HAI with A/Perth/16/2009 virus. This analysis showed that 11.1% of children receiving the AS03B-adjuvanted vaccine but only 1.4% in the non-adjuvanted group had a 4-fold rise to A/Perth/16/2009.
Conclusion: AS03B-adjuvanted A(H1N1)pdm09 influenza vaccine generates a cross-reactive antibody response to H3N2 in children and enhances responses to heterologous subtypes in <3-year-old children one year later.
Hoschler, Katja
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Andrews, Nick J.
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Faust, S.N.
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Finn, Adam
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Pollard, Andrew J.
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Snape, Matthew D.
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Walker, Woolf T.
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Zambon, Maria
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Miller, Elizabeth
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Hoschler, Katja
d5667e00-59ee-4723-8622-b851064deba8
Andrews, Nick J.
a262c189-ff23-45de-822c-213d6dcedad9
Faust, S.N.
f97df780-9f9b-418e-b349-7adf63e150c1
Finn, Adam
59ac74fa-55a6-448d-9e19-9dd2f4654d4b
Pollard, Andrew J.
f54083f3-c730-4ecb-937e-6fb11fdd6a21
Snape, Matthew D.
ea21c8b9-e907-4914-9052-ae9eb56f54d7
Walker, Woolf T.
58aae223-5b0e-4f34-9ee7-58bb68278c3a
Zambon, Maria
7537de23-07fa-4404-9f95-9627ce13b3f3
Miller, Elizabeth
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Hoschler, Katja, Andrews, Nick J., Faust, S.N., Finn, Adam, Pollard, Andrew J., Snape, Matthew D., Walker, Woolf T., Zambon, Maria and Miller, Elizabeth
(2013)
Administration of AS03B-adjuvanted A(H1N1)pdm09 vaccine in children under 3 years enhances antibody response to H3 and B viruses following a single dose of trivalent vaccine one year later.
Clinical Infectious Diseases.
(doi:10.1093/cid/cit692).
(PMID:24149079)
Abstract
Background: We report a follow up clinical and serological investigation of 274 children receiving seasonal influenza vaccine (TIV) one year after receipt of either AS03B-adjuvanted subunit or whole virus monovalent A(H1N1)pdm09 vaccine and describe the antibody responses to the H3N2 A/Perth/16/2009 and B/Brisbane/60/2008 components of TIV.
Method and Findings: Vaccine responses were analysed using Haemagglutination Inhibition (HAI) assays. In individuals under 3 years of age, previous receipt of adjuvanted vaccine resulted in higher HAI antibody responses to H3N2 and B strains compared to non-adjuvanted vaccine (fold change 16.8 vs 4.3 for H3N2 and 7.0 vs 1.6 for B). In older children, responses to the H3 and B components of TIV were similar between vaccine groups. Sera taken pre- and post pandemic vaccine were also analysed by HAI with A/Perth/16/2009 virus. This analysis showed that 11.1% of children receiving the AS03B-adjuvanted vaccine but only 1.4% in the non-adjuvanted group had a 4-fold rise to A/Perth/16/2009.
Conclusion: AS03B-adjuvanted A(H1N1)pdm09 influenza vaccine generates a cross-reactive antibody response to H3N2 in children and enhances responses to heterologous subtypes in <3-year-old children one year later.
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e-pub ahead of print date: 22 October 2013
Organisations:
Faculty of Medicine
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Local EPrints ID: 359210
URI: http://eprints.soton.ac.uk/id/eprint/359210
ISSN: 1058-4838
PURE UUID: 9d642a46-38e3-46ae-af4b-7fbefb5d9494
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Date deposited: 23 Oct 2013 13:24
Last modified: 15 Mar 2024 03:26
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Author:
Katja Hoschler
Author:
Nick J. Andrews
Author:
Adam Finn
Author:
Andrew J. Pollard
Author:
Matthew D. Snape
Author:
Woolf T. Walker
Author:
Maria Zambon
Author:
Elizabeth Miller
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