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Resolution of fatty liver and risk of incident diabetes

Resolution of fatty liver and risk of incident diabetes
Resolution of fatty liver and risk of incident diabetes
CONTEXT: Fatty liver is associated with an increased risk of type 2 diabetes, but whether an increased risk remains in people in whom fatty liver resolves over time is not known.

OBJECTIVE: The objective of the study was to assess the risk of incident diabetes at a 5-year follow-up in people in whom: 1) new fatty liver developed; 2) existing fatty liver resolved, and 3) fatty liver severity worsened over 5 years.

DESIGN AND METHODS: A total of 13,218 people without diabetes at baseline from a Korean occupational cohort were examined at baseline and after 5 years, using a retrospective study design. Fatty liver status was assessed at baseline and follow-up as absent, mild, or moderate/severe using standard ultrasound criteria. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for incident diabetes at follow-up were estimated after controlling for multiple potential confounders.

RESULTS: Two hundred thirty-four people developed incident diabetes. Over 5 years, fatty liver resolved in 828, developed in 1640, and progressed from mild to moderate/severe in 324 people. Resolution of fatty liver was not associated with a risk of incident diabetes [aOR 0.95 (95% CIs 0.46, 1.96), P = .89]. Development of new fatty liver was associated with incident diabetes [aOR 2.49 (95% CI 1.49, 4.14), P < .001]. In individuals in whom severity of fatty liver worsened over 5 years (from mild to moderate/severe), there was a marked increase in the risk of incident diabetes [aOR 6.13 (2.56, 95% CI 14.68) P < .001 (compared with the risk in people with resolution of fatty liver)].

CONCLUSION: Change in fatty liver status over time is associated with markedly variable risks of incident diabetes.
0021-972X
3637-3643
Sung, K.C.
be77bd09-0bba-4fcf-8096-c0049ce4e2ce
Wild, S.H.
eb23a87e-b8da-4f3f-8dab-e02e7b5104aa
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Sung, K.C.
be77bd09-0bba-4fcf-8096-c0049ce4e2ce
Wild, S.H.
eb23a87e-b8da-4f3f-8dab-e02e7b5104aa
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c

Sung, K.C., Wild, S.H. and Byrne, Christopher D. (2013) Resolution of fatty liver and risk of incident diabetes. Journal of Clinical Endocrinology & Metabolism, 98 (9), 3637-3643. (doi:10.1210/jc.2013-1519). (PMID:23873989)

Record type: Article

Abstract

CONTEXT: Fatty liver is associated with an increased risk of type 2 diabetes, but whether an increased risk remains in people in whom fatty liver resolves over time is not known.

OBJECTIVE: The objective of the study was to assess the risk of incident diabetes at a 5-year follow-up in people in whom: 1) new fatty liver developed; 2) existing fatty liver resolved, and 3) fatty liver severity worsened over 5 years.

DESIGN AND METHODS: A total of 13,218 people without diabetes at baseline from a Korean occupational cohort were examined at baseline and after 5 years, using a retrospective study design. Fatty liver status was assessed at baseline and follow-up as absent, mild, or moderate/severe using standard ultrasound criteria. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for incident diabetes at follow-up were estimated after controlling for multiple potential confounders.

RESULTS: Two hundred thirty-four people developed incident diabetes. Over 5 years, fatty liver resolved in 828, developed in 1640, and progressed from mild to moderate/severe in 324 people. Resolution of fatty liver was not associated with a risk of incident diabetes [aOR 0.95 (95% CIs 0.46, 1.96), P = .89]. Development of new fatty liver was associated with incident diabetes [aOR 2.49 (95% CI 1.49, 4.14), P < .001]. In individuals in whom severity of fatty liver worsened over 5 years (from mild to moderate/severe), there was a marked increase in the risk of incident diabetes [aOR 6.13 (2.56, 95% CI 14.68) P < .001 (compared with the risk in people with resolution of fatty liver)].

CONCLUSION: Change in fatty liver status over time is associated with markedly variable risks of incident diabetes.

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More information

Published date: 19 June 2013
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 359301
URI: http://eprints.soton.ac.uk/id/eprint/359301
ISSN: 0021-972X
PURE UUID: b5a66083-8636-4d4d-b682-db95b8fa4414
ORCID for Christopher D. Byrne: ORCID iD orcid.org/0000-0001-6322-7753

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Date deposited: 25 Oct 2013 13:01
Last modified: 23 Jul 2022 01:45

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Contributors

Author: K.C. Sung
Author: S.H. Wild

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