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Improving cellular adhesion on scaffolds for transplantation: synthesising a poly(MMA-co-PEGM) network

Improving cellular adhesion on scaffolds for transplantation: synthesising a poly(MMA-co-PEGM) network
Improving cellular adhesion on scaffolds for transplantation: synthesising a poly(MMA-co-PEGM) network
Electrospun fibrous matrices prepared from methacrylate-based copolymers are investigated as a tool for retinal pigment epithelium (RPE) transplantation in the treatment of degenerative retinal diseases. Human RPE cells were used to probe the cell-surface interactions on these copolymer matrices. For the first time, simple changes in chemical functionality have been found to induce gel formation of these methacrylate backbone copolymers in vitro. This effect is shown to significantly improve RPE cell adhesion and survival.
2050-750X
Pitt, Darren William
54e007c9-cd15-4a7a-982b-6732b7a2a382
Treharne, Andrew John
a158bb09-9d41-4b3a-ae02-ccbd76dd9417
Thomson, Heather A.
dcc04060-5cd0-4c79-950b-da79557b3899
Scott, Jennifer A.
a8d2adb9-5eb1-4efd-bc65-5dde57b12fc1
Lotery, Andrew John
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Grossel, Martin Christopher
403bf3ff-6364-44e9-ab46-52d84c6f0d56
Pitt, Darren William
54e007c9-cd15-4a7a-982b-6732b7a2a382
Treharne, Andrew John
a158bb09-9d41-4b3a-ae02-ccbd76dd9417
Thomson, Heather A.
dcc04060-5cd0-4c79-950b-da79557b3899
Scott, Jennifer A.
a8d2adb9-5eb1-4efd-bc65-5dde57b12fc1
Lotery, Andrew John
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Grossel, Martin Christopher
403bf3ff-6364-44e9-ab46-52d84c6f0d56

Pitt, Darren William, Treharne, Andrew John, Thomson, Heather A., Scott, Jennifer A., Lotery, Andrew John and Grossel, Martin Christopher (2013) Improving cellular adhesion on scaffolds for transplantation: synthesising a poly(MMA-co-PEGM) network. Journal of Materials Chemistry B, n/a. (doi:10.1039/C3TB21248C).

Record type: Article

Abstract

Electrospun fibrous matrices prepared from methacrylate-based copolymers are investigated as a tool for retinal pigment epithelium (RPE) transplantation in the treatment of degenerative retinal diseases. Human RPE cells were used to probe the cell-surface interactions on these copolymer matrices. For the first time, simple changes in chemical functionality have been found to induce gel formation of these methacrylate backbone copolymers in vitro. This effect is shown to significantly improve RPE cell adhesion and survival.

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More information

Published date: 29 October 2013
Organisations: Organic Chemistry: Synthesis, Catalysis and Flow, Chemistry, Faculty of Natural and Environmental Sciences, Faculty of Medicine

Identifiers

Local EPrints ID: 359404
URI: http://eprints.soton.ac.uk/id/eprint/359404
ISSN: 2050-750X
PURE UUID: 98054610-fcb6-4f76-90ad-e795e7c04f1d
ORCID for Andrew John Lotery: ORCID iD orcid.org/0000-0001-5541-4305
ORCID for Martin Christopher Grossel: ORCID iD orcid.org/0000-0001-7469-6854

Catalogue record

Date deposited: 01 Nov 2013 13:44
Last modified: 20 Jul 2019 01:21

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Contributors

Author: Darren William Pitt
Author: Andrew John Treharne
Author: Heather A. Thomson
Author: Jennifer A. Scott

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