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Value of biomarkers in steoarthritis: current status and perspectives

Value of biomarkers in steoarthritis: current status and perspectives
Value of biomarkers in steoarthritis: current status and perspectives
Osteoarthritis affects the whole joint structure with progressive changes in cartilage, menisci, ligaments and subchondral bone, and synovial inflammation. Biomarkers are being developed to quantify joint remodelling and disease progression. This article was prepared following a working meeting of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis convened to discuss the value of biochemical markers of matrix metabolism in drug development in osteoarthritis. The best candidates are generally molecules or molecular fragments present in cartilage, bone or synovium and may be specific to one type of joint tissue or common to them all. Many currently investigated biomarkers are associated with collagen metabolism in cartilage or bone, or aggrecan metabolism in cartilage. Other biomarkers are related to non-collagenous proteins, inflammation and/or fibrosis. Biomarkers in osteoarthritis can be categorised using the burden of disease, investigative, prognostic, efficacy of intervention, diagnostic and safety classification. There are a number of promising candidates, notably urinary C-terminal telopeptide of collagen type II and serum cartilage oligomeric protein, although none is sufficiently discriminating to differentiate between individual patients and controls (diagnostic) or between patients with different disease severities (burden of disease), predict prognosis in individuals with or without osteoarthritis (prognostic) or perform so consistently that it could function as a surrogate outcome in clinical trials (efficacy of intervention). Future avenues for research include exploration of underlying mechanisms of disease and development of new biomarkers; technological development; the 'omics' (genomics, metabolomics, proteomics and lipidomics); design of aggregate scores combining a panel of biomarkers and/or imaging markers into single diagnostic algorithms; and investigation into the relationship between biomarkers and prognosis.
0003-4967
1756-1763
Lotz, M.
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Martel-Pelletier, J.
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Christiansen, C.
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Brandi, M.L.
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Bruyere, O.
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Chapurlat, R.
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Collette, J.
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Cooper, C.
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Giacovelli, G.
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Kanis, J.A.
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Karsdal, M.A.
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Kraus, V.
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Lems, W.F.
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Meulenbelt, I.
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Pelletier, J.P.
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Raynauld, J.P.
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Reiter-Niesert, S.
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Rizzoli, R.
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Sandell, L.J.
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Van Spil, W.E.
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Reginster, J.Y.
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Lotz, M.
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Martel-Pelletier, J.
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Christiansen, C.
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Brandi, M.L.
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Bruyere, O.
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Chapurlat, R.
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Collette, J.
1bfd0a67-7825-4858-9996-214594e6e42b
Cooper, C.
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Giacovelli, G.
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Kanis, J.A.
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Karsdal, M.A.
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Kraus, V.
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Lems, W.F.
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Meulenbelt, I.
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Pelletier, J.P.
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Raynauld, J.P.
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Reiter-Niesert, S.
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Rizzoli, R.
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Sandell, L.J.
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Van Spil, W.E.
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Reginster, J.Y.
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Lotz, M., Martel-Pelletier, J., Christiansen, C., Brandi, M.L., Bruyere, O., Chapurlat, R., Collette, J., Cooper, C., Giacovelli, G., Kanis, J.A., Karsdal, M.A., Kraus, V., Lems, W.F., Meulenbelt, I., Pelletier, J.P., Raynauld, J.P., Reiter-Niesert, S., Rizzoli, R., Sandell, L.J., Van Spil, W.E. and Reginster, J.Y. (2013) Value of biomarkers in steoarthritis: current status and perspectives. Annals of the Rheumatic Diseases, 72 (11), 1756-1763. (doi:10.1136/annrheumdis-2013-203726). (PMID:23897772)

Record type: Article

Abstract

Osteoarthritis affects the whole joint structure with progressive changes in cartilage, menisci, ligaments and subchondral bone, and synovial inflammation. Biomarkers are being developed to quantify joint remodelling and disease progression. This article was prepared following a working meeting of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis convened to discuss the value of biochemical markers of matrix metabolism in drug development in osteoarthritis. The best candidates are generally molecules or molecular fragments present in cartilage, bone or synovium and may be specific to one type of joint tissue or common to them all. Many currently investigated biomarkers are associated with collagen metabolism in cartilage or bone, or aggrecan metabolism in cartilage. Other biomarkers are related to non-collagenous proteins, inflammation and/or fibrosis. Biomarkers in osteoarthritis can be categorised using the burden of disease, investigative, prognostic, efficacy of intervention, diagnostic and safety classification. There are a number of promising candidates, notably urinary C-terminal telopeptide of collagen type II and serum cartilage oligomeric protein, although none is sufficiently discriminating to differentiate between individual patients and controls (diagnostic) or between patients with different disease severities (burden of disease), predict prognosis in individuals with or without osteoarthritis (prognostic) or perform so consistently that it could function as a surrogate outcome in clinical trials (efficacy of intervention). Future avenues for research include exploration of underlying mechanisms of disease and development of new biomarkers; technological development; the 'omics' (genomics, metabolomics, proteomics and lipidomics); design of aggregate scores combining a panel of biomarkers and/or imaging markers into single diagnostic algorithms; and investigation into the relationship between biomarkers and prognosis.

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Published date: 1 November 2013
Organisations: Faculty of Medicine

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Local EPrints ID: 359462
URI: http://eprints.soton.ac.uk/id/eprint/359462
ISSN: 0003-4967
PURE UUID: d1c5310d-558b-492e-aa3a-2c6193868865
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 04 Nov 2013 13:34
Last modified: 26 Nov 2019 01:58

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Contributors

Author: M. Lotz
Author: J. Martel-Pelletier
Author: C. Christiansen
Author: M.L. Brandi
Author: O. Bruyere
Author: R. Chapurlat
Author: J. Collette
Author: C. Cooper ORCID iD
Author: G. Giacovelli
Author: J.A. Kanis
Author: M.A. Karsdal
Author: V. Kraus
Author: W.F. Lems
Author: I. Meulenbelt
Author: J.P. Pelletier
Author: J.P. Raynauld
Author: S. Reiter-Niesert
Author: R. Rizzoli
Author: L.J. Sandell
Author: W.E. Van Spil
Author: J.Y. Reginster

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