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Varicella zoster virus central nervous system immune reconstitution inflammatory syndrome presenting in a child

Varicella zoster virus central nervous system immune reconstitution inflammatory syndrome presenting in a child
Varicella zoster virus central nervous system immune reconstitution inflammatory syndrome presenting in a child
A HIV-positive child presented with acute onset of right hemiplegia, facial palsy and dysphasia 4 weeks after commencing highly active antiretroviral therapy. Magnetic resonance imaging confirmed a left-sided cerebral infarct. Cerebrospinal fluid polymerase chain reaction was positive for varicella zoster virus. This is the first reported pediatric case of varicella zoster virus–related immune reconstitution inflammatory syndrome involving the central nervous system.
immune reconstitution inflammatory syndrome, central nervous system, hiv, varicella zoster virus, stroke
1283-1284
Iro, M.A.
caa726c4-826c-4c86-91fd-a9db511b2959
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Macdonald, J.H.M.
b553dcbb-ec5c-43df-9004-51409f603343
Tebruegge, Marc
2c3dff22-0b5f-48a7-bb36-ce323705f74a
Faust, S.N.
f97df780-9f9b-418e-b349-7adf63e150c1
Patel, Sanjay V.
3a22c83b-5edb-471c-997b-dbad703b6ede
Iro, M.A.
caa726c4-826c-4c86-91fd-a9db511b2959
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Macdonald, J.H.M.
b553dcbb-ec5c-43df-9004-51409f603343
Tebruegge, Marc
2c3dff22-0b5f-48a7-bb36-ce323705f74a
Faust, S.N.
f97df780-9f9b-418e-b349-7adf63e150c1
Patel, Sanjay V.
3a22c83b-5edb-471c-997b-dbad703b6ede

Iro, M.A., Kirkham, Fenella J., Macdonald, J.H.M., Tebruegge, Marc, Faust, S.N. and Patel, Sanjay V. (2013) Varicella zoster virus central nervous system immune reconstitution inflammatory syndrome presenting in a child. Pediatric Infectious Disease Journal, 32 (11), 1283-1284. (doi:10.1097/INF.0b013e31829aa4fc).

Record type: Article

Abstract

A HIV-positive child presented with acute onset of right hemiplegia, facial palsy and dysphasia 4 weeks after commencing highly active antiretroviral therapy. Magnetic resonance imaging confirmed a left-sided cerebral infarct. Cerebrospinal fluid polymerase chain reaction was positive for varicella zoster virus. This is the first reported pediatric case of varicella zoster virus–related immune reconstitution inflammatory syndrome involving the central nervous system.

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More information

Published date: November 2013
Keywords: immune reconstitution inflammatory syndrome, central nervous system, hiv, varicella zoster virus, stroke
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 359464
URI: http://eprints.soton.ac.uk/id/eprint/359464
PURE UUID: 2b4ad91e-40fd-4393-8c28-0dc3f6d7fc71
ORCID for Fenella J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958
ORCID for S.N. Faust: ORCID iD orcid.org/0000-0003-3410-7642

Catalogue record

Date deposited: 04 Nov 2013 13:41
Last modified: 18 Feb 2021 17:07

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Contributors

Author: M.A. Iro
Author: J.H.M. Macdonald
Author: Marc Tebruegge
Author: S.N. Faust ORCID iD
Author: Sanjay V. Patel

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