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Five-year fracture risk estimation in patients with Parkinson's disease

Five-year fracture risk estimation in patients with Parkinson's disease
Five-year fracture risk estimation in patients with Parkinson's disease
Background
Previous studies have shown that patients with Parkinson's disease (PD) are at increased risk of fractures. However, no specific prediction model for fracture estimation among PD patients is currently available. Therefore, the aim of this study was to develop a simple score for estimating the 5-year osteoporotic and hip fracture risks among patients with PD.

Methods
The UK Clinical Practice Research Datalink (1987–2011) was used to identify incident PD patients. Cox proportional-hazards models were used to calculate the 5-year risks of osteoporotic and hip fracture among PD patients. The regression model was fitted with various risk factors for fracture and the final Cox model was converted into integer risk scores.

Results
We identified 4411 incident PD patients without a history of osteoporotic treatment. The 5-year risks of osteoporotic and hip fracture were plotted in relation to the risk score. Risk scores increased with age, female gender, history of renal disease and history of dementia. The C-statistic, which is a parameter to test the internal validity of the model, was reasonable for the prediction of osteoporotic fracture (0.69) and hip fracture (0.73).

Conclusion
In this study, we developed a simple model to estimate 5-year fracture risk among incident PD patients. It may be useful in daily practice after external validation.

epidemiology, prevention, parkinson's disease, fracture
8756-3282
266-270
Pouwels, S.
3d97460d-5b2e-4ec6-b46f-e82e338cf0c1
Bazelier, M.T.
18718009-818b-44f6-8784-bf8a958f0164
de Boer, A.
5621b588-a1e0-4827-8940-89efef278f13
Weber, W.E.
af82da4f-31c6-432a-9d69-a578c4275bbb
Neef, C.K.
1fa20556-b266-4bed-a6b3-fd51adaecf84
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
de Vries, F.
db4c0543-d6e7-476b-a10e-52d9d483f613
Pouwels, S.
3d97460d-5b2e-4ec6-b46f-e82e338cf0c1
Bazelier, M.T.
18718009-818b-44f6-8784-bf8a958f0164
de Boer, A.
5621b588-a1e0-4827-8940-89efef278f13
Weber, W.E.
af82da4f-31c6-432a-9d69-a578c4275bbb
Neef, C.K.
1fa20556-b266-4bed-a6b3-fd51adaecf84
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
de Vries, F.
db4c0543-d6e7-476b-a10e-52d9d483f613

Pouwels, S., Bazelier, M.T., de Boer, A., Weber, W.E., Neef, C.K., Cooper, C. and de Vries, F. (2013) Five-year fracture risk estimation in patients with Parkinson's disease. Bone, 56 (2), 266-270. (doi:10.1016/j.bone.2013.06.018). (PMID:23800516)

Record type: Article

Abstract

Background
Previous studies have shown that patients with Parkinson's disease (PD) are at increased risk of fractures. However, no specific prediction model for fracture estimation among PD patients is currently available. Therefore, the aim of this study was to develop a simple score for estimating the 5-year osteoporotic and hip fracture risks among patients with PD.

Methods
The UK Clinical Practice Research Datalink (1987–2011) was used to identify incident PD patients. Cox proportional-hazards models were used to calculate the 5-year risks of osteoporotic and hip fracture among PD patients. The regression model was fitted with various risk factors for fracture and the final Cox model was converted into integer risk scores.

Results
We identified 4411 incident PD patients without a history of osteoporotic treatment. The 5-year risks of osteoporotic and hip fracture were plotted in relation to the risk score. Risk scores increased with age, female gender, history of renal disease and history of dementia. The C-statistic, which is a parameter to test the internal validity of the model, was reasonable for the prediction of osteoporotic fracture (0.69) and hip fracture (0.73).

Conclusion
In this study, we developed a simple model to estimate 5-year fracture risk among incident PD patients. It may be useful in daily practice after external validation.

Full text not available from this repository.

More information

Published date: October 2013
Keywords: epidemiology, prevention, parkinson's disease, fracture
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 359484
URI: http://eprints.soton.ac.uk/id/eprint/359484
ISSN: 8756-3282
PURE UUID: e48b8578-4996-47e0-90d6-85e4d6d1bfe5
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 04 Nov 2013 15:21
Last modified: 20 Jul 2019 01:14

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Contributors

Author: S. Pouwels
Author: M.T. Bazelier
Author: A. de Boer
Author: W.E. Weber
Author: C.K. Neef
Author: C. Cooper ORCID iD
Author: F. de Vries

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