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Multinational evidence-based recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion of a broad panel of rheumatologists in the 3e initiative

Multinational evidence-based recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion of a broad panel of rheumatologists in the 3e initiative
Multinational evidence-based recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion of a broad panel of rheumatologists in the 3e initiative
We aimed to develop evidence-based multinational recommendations for the diagnosis and management of gout. Using a formal voting process, a panel of 78 international rheumatologists developed 10 key clinical questions pertinent to the diagnosis and management of gout. Each question was investigated with a systematic literature review. Medline, Embase, Cochrane CENTRAL and abstracts from 2010–2011 European League Against Rheumatism and American College of Rheumatology meetings were searched in each review. Relevant studies were independently reviewed by two individuals for data extraction and synthesis and risk of bias assessment. Using this evidence, rheumatologists from 14 countries (Europe, South America and Australasia) developed national recommendations. After rounds of discussion and voting, multinational recommendations were formulated. Each recommendation was graded according to the level of evidence. Agreement and potential impact on clinical practice were assessed. Combining evidence and clinical expertise, 10 recommendations were produced. One recommendation referred to the diagnosis of gout, two referred to cardiovascular and renal comorbidities, six focused on different aspects of the management of gout (including drug treatment and monitoring), and the last recommendation referred to the management of asymptomatic hyperuricaemia. The level of agreement with the recommendations ranged from 8.1 to 9.2 (mean 8.7) on a 1–10 scale, with 10 representing full agreement. Ten recommendations on the diagnosis and management of gout were established. They are evidence-based and supported by a large panel of rheumatologists from 14 countries, enhancing their utility in clinical practice.

0003-4967
Sivera, F.
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Andrés, M.
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Carmona, L.
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Kydd, A.S.
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Moi, J.
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Seth, R
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Sriranganathan, M.
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van Durme, C.
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van Echteld, I.
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Vinik, O.
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Wechalekar, M.D.
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Aletaha, D.
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Bombardier, C.
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Buchbinder, R.
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Edwards, C.J.
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Landewé, R.B.
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Kiely, P.
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Leeb, B.F.
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Montecucco, C.
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Müller-Ladner, U.
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Zochling, J.
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Falzon, L.
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van der Heijde, D.M.
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Sivera, F.
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Andrés, M.
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Carmona, L.
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Kydd, A.S.
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Moi, J.
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Seth, R
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Sriranganathan, M.
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van Durme, C.
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van Echteld, I.
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Vinik, O.
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Wechalekar, M.D.
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Aletaha, D.
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Bombardier, C.
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Buchbinder, R.
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Edwards, C.J.
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Landewé, R.B.
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Bijlsma, J.W.
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Catrina, A.I.
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Elewaut, D.
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Ferrari, A.J.
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Kiely, P.
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Leeb, B.F.
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Montecucco, C.
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Müller-Ladner, U.
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Ostergaard, M.
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Zochling, J.
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Falzon, L.
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van der Heijde, D.M.
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Sivera, F., Andrés, M., Carmona, L., Kydd, A.S., Moi, J., Seth, R, Sriranganathan, M., van Durme, C., van Echteld, I., Vinik, O., Wechalekar, M.D., Aletaha, D., Bombardier, C., Buchbinder, R., Edwards, C.J., Landewé, R.B., Bijlsma, J.W., Branco, J.C., Burgos-Vargas, R., Catrina, A.I., Elewaut, D., Ferrari, A.J., Kiely, P., Leeb, B.F., Montecucco, C., Müller-Ladner, U., Ostergaard, M., Zochling, J., Falzon, L. and van der Heijde, D.M. (2013) Multinational evidence-based recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion of a broad panel of rheumatologists in the 3e initiative. Annals of the Rheumatic Diseases. (doi:10.1136/annrheumdis-2013-203325).

Record type: Article

Abstract

We aimed to develop evidence-based multinational recommendations for the diagnosis and management of gout. Using a formal voting process, a panel of 78 international rheumatologists developed 10 key clinical questions pertinent to the diagnosis and management of gout. Each question was investigated with a systematic literature review. Medline, Embase, Cochrane CENTRAL and abstracts from 2010–2011 European League Against Rheumatism and American College of Rheumatology meetings were searched in each review. Relevant studies were independently reviewed by two individuals for data extraction and synthesis and risk of bias assessment. Using this evidence, rheumatologists from 14 countries (Europe, South America and Australasia) developed national recommendations. After rounds of discussion and voting, multinational recommendations were formulated. Each recommendation was graded according to the level of evidence. Agreement and potential impact on clinical practice were assessed. Combining evidence and clinical expertise, 10 recommendations were produced. One recommendation referred to the diagnosis of gout, two referred to cardiovascular and renal comorbidities, six focused on different aspects of the management of gout (including drug treatment and monitoring), and the last recommendation referred to the management of asymptomatic hyperuricaemia. The level of agreement with the recommendations ranged from 8.1 to 9.2 (mean 8.7) on a 1–10 scale, with 10 representing full agreement. Ten recommendations on the diagnosis and management of gout were established. They are evidence-based and supported by a large panel of rheumatologists from 14 countries, enhancing their utility in clinical practice.

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More information

Published date: 18 July 2013
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 359487
URI: http://eprints.soton.ac.uk/id/eprint/359487
ISSN: 0003-4967
PURE UUID: f5a5e0bf-68e9-446d-8858-5d3eae2b6390

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Date deposited: 04 Nov 2013 11:53
Last modified: 08 Jan 2022 06:07

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Contributors

Author: F. Sivera
Author: M. Andrés
Author: L. Carmona
Author: A.S. Kydd
Author: J. Moi
Author: R Seth
Author: M. Sriranganathan
Author: C. van Durme
Author: I. van Echteld
Author: O. Vinik
Author: M.D. Wechalekar
Author: D. Aletaha
Author: C. Bombardier
Author: R. Buchbinder
Author: C.J. Edwards
Author: R.B. Landewé
Author: J.W. Bijlsma
Author: J.C. Branco
Author: R. Burgos-Vargas
Author: A.I. Catrina
Author: D. Elewaut
Author: A.J. Ferrari
Author: P. Kiely
Author: B.F. Leeb
Author: C. Montecucco
Author: U. Müller-Ladner
Author: M. Ostergaard
Author: J. Zochling
Author: L. Falzon
Author: D.M. van der Heijde

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