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Early growth and non-alcoholic fatty liver disease in adulthood-the NAFLD liver fat score and equation applied on the Helsinki Birth Cohort Study.

Early growth and non-alcoholic fatty liver disease in adulthood-the NAFLD liver fat score and equation applied on the Helsinki Birth Cohort Study.
Early growth and non-alcoholic fatty liver disease in adulthood-the NAFLD liver fat score and equation applied on the Helsinki Birth Cohort Study.
Introduction: prenatal and childhood growth influence the risk of developing the metabolic syndrome and type 2 diabetes. Both conditions are associated with non-alcoholic fatty liver disease (NAFLD). Our aim was to explore the associations between early growth and adult NAFLD.

Methods: we studied 1587 individuals from the Helsinki Birth Cohort Study (HBCS) born 1934–44 for whom birth, childhood, and adult clinical data were available. NAFLD was defined using the NAFLD liver fat score and equation. The score was converted into a dichotomous variable, with outcomes defined as either a positive or negative score. The equation predicts liver fat percentage.

Results: a positive score was found in 43% of men and 22.5% of women. Several measurements of birth and childhood body size were negatively associated with both NAFLD outcomes after adjustment for adult BMI. Those from the smallest BMI tertile at age 2 who were obese in adulthood had an OR of 18.5 for a positive score compared to those from the same group who were normal weight in adulthood.

Conclusions: a larger childhood body size was negatively associated with NAFLD outcomes. Individuals who are small during early childhood and obese as adults seem to be at the highest risk of developing NAFLD

0785-3890
430-437
Sandboge, S.
60effc3d-f537-49c1-b675-960c60d4383e
Perala, M.M.
2eb306a3-7103-4877-81c9-858afc568af9
Salonen, M.K.
376ccd5d-a164-40aa-b0d6-5117ce2e7e56
Blomstedt, P.A.
f06c5624-eaab-48a4-89b5-3a5db28dac02
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Kajantie, E.
d4e32f85-9988-4b83-b353-012210ea0151
Barker, D.J.
cabc3433-b628-43e5-9fd7-e6ff5769bf44
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
Sandboge, S.
60effc3d-f537-49c1-b675-960c60d4383e
Perala, M.M.
2eb306a3-7103-4877-81c9-858afc568af9
Salonen, M.K.
376ccd5d-a164-40aa-b0d6-5117ce2e7e56
Blomstedt, P.A.
f06c5624-eaab-48a4-89b5-3a5db28dac02
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Kajantie, E.
d4e32f85-9988-4b83-b353-012210ea0151
Barker, D.J.
cabc3433-b628-43e5-9fd7-e6ff5769bf44
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b

Sandboge, S., Perala, M.M., Salonen, M.K., Blomstedt, P.A., Osmond, C., Kajantie, E., Barker, D.J. and Eriksson, J.G. (2013) Early growth and non-alcoholic fatty liver disease in adulthood-the NAFLD liver fat score and equation applied on the Helsinki Birth Cohort Study. Annals of Medicine, 45 (5-6), 430-437. (doi:10.3109/07853890.2013.801275.). (PMID:23767967)

Record type: Article

Abstract

Introduction: prenatal and childhood growth influence the risk of developing the metabolic syndrome and type 2 diabetes. Both conditions are associated with non-alcoholic fatty liver disease (NAFLD). Our aim was to explore the associations between early growth and adult NAFLD.

Methods: we studied 1587 individuals from the Helsinki Birth Cohort Study (HBCS) born 1934–44 for whom birth, childhood, and adult clinical data were available. NAFLD was defined using the NAFLD liver fat score and equation. The score was converted into a dichotomous variable, with outcomes defined as either a positive or negative score. The equation predicts liver fat percentage.

Results: a positive score was found in 43% of men and 22.5% of women. Several measurements of birth and childhood body size were negatively associated with both NAFLD outcomes after adjustment for adult BMI. Those from the smallest BMI tertile at age 2 who were obese in adulthood had an OR of 18.5 for a positive score compared to those from the same group who were normal weight in adulthood.

Conclusions: a larger childhood body size was negatively associated with NAFLD outcomes. Individuals who are small during early childhood and obese as adults seem to be at the highest risk of developing NAFLD

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Published date: September 2013
Organisations: Faculty of Medicine

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Local EPrints ID: 359601
URI: http://eprints.soton.ac.uk/id/eprint/359601
ISSN: 0785-3890
PURE UUID: 2f0832d5-3368-41be-925b-480672a5c832
ORCID for C. Osmond: ORCID iD orcid.org/0000-0002-9054-4655

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Date deposited: 07 Nov 2013 11:11
Last modified: 18 Feb 2021 16:45

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Contributors

Author: S. Sandboge
Author: M.M. Perala
Author: M.K. Salonen
Author: P.A. Blomstedt
Author: C. Osmond ORCID iD
Author: E. Kajantie
Author: D.J. Barker
Author: J.G. Eriksson

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