The University of Southampton
University of Southampton Institutional Repository

New insights into mechanisms behind miscarriage

New insights into mechanisms behind miscarriage
New insights into mechanisms behind miscarriage
Sporadic miscarriage is the most common complication of early pregnancy. Two or three consecutive pregnancy losses is a less common phenomenon, and this is considered a distinct disease entity. Sporadic miscarriages are considered to primarily represent failure of abnormal embryos to progress to viability. Recurrent miscarriage is thought to have multiple etiologies, including parental chromosomal anomalies, maternal thrombophilic disorders, immune dysfunction and various endocrine disturbances. However, none of these conditions is specific to recurrent miscarriage or always associated with repeated early pregnancy loss. In recent years, new theories about the mechanisms behind sporadic and recurrent miscarriage have emerged. Epidemiological and genetic studies suggest a multifactorial background where immunological dysregulation in pregnancy may play a role, as well as lifestyle factors and changes in sperm DNA integrity. Recent experimental evidence has led to the concept that the decidualized endometrium acts as biosensor of embryo quality, which if disrupted, may lead to implantation of embryos destined to miscarry. These new insights into the mechanisms behind miscarriage offer the prospect of novel effective interventions that may prevent this distressing condition
154
Larsen, E.C.
64321a38-ddf5-4376-ad15-89e134cb9ad6
Christiansen, O.B.
4fd4a582-4510-4721-b05e-737be2eb0750
Kolte, A.M.
2bf6e9e9-1c44-46c1-85cd-99b2d8502a4a
Macklon, N.S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Larsen, E.C.
64321a38-ddf5-4376-ad15-89e134cb9ad6
Christiansen, O.B.
4fd4a582-4510-4721-b05e-737be2eb0750
Kolte, A.M.
2bf6e9e9-1c44-46c1-85cd-99b2d8502a4a
Macklon, N.S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e

Larsen, E.C., Christiansen, O.B., Kolte, A.M. and Macklon, N.S. (2013) New insights into mechanisms behind miscarriage. BMC Medicine, 11, 154. (doi:10.1186/1741-7015-11-154). (PMID:23803387)

Record type: Article

Abstract

Sporadic miscarriage is the most common complication of early pregnancy. Two or three consecutive pregnancy losses is a less common phenomenon, and this is considered a distinct disease entity. Sporadic miscarriages are considered to primarily represent failure of abnormal embryos to progress to viability. Recurrent miscarriage is thought to have multiple etiologies, including parental chromosomal anomalies, maternal thrombophilic disorders, immune dysfunction and various endocrine disturbances. However, none of these conditions is specific to recurrent miscarriage or always associated with repeated early pregnancy loss. In recent years, new theories about the mechanisms behind sporadic and recurrent miscarriage have emerged. Epidemiological and genetic studies suggest a multifactorial background where immunological dysregulation in pregnancy may play a role, as well as lifestyle factors and changes in sperm DNA integrity. Recent experimental evidence has led to the concept that the decidualized endometrium acts as biosensor of embryo quality, which if disrupted, may lead to implantation of embryos destined to miscarry. These new insights into the mechanisms behind miscarriage offer the prospect of novel effective interventions that may prevent this distressing condition

This record has no associated files available for download.

More information

Published date: June 2013
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 359610
URI: http://eprints.soton.ac.uk/id/eprint/359610
PURE UUID: 63d31adc-0a5f-4414-ba72-e14540e45cca

Catalogue record

Date deposited: 07 Nov 2013 12:02
Last modified: 27 Apr 2022 09:46

Export record

Altmetrics

Contributors

Author: E.C. Larsen
Author: O.B. Christiansen
Author: A.M. Kolte
Author: N.S. Macklon

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×