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Consensus statement on research definitions for drug-resistant tuberculosis in children

Consensus statement on research definitions for drug-resistant tuberculosis in children
Consensus statement on research definitions for drug-resistant tuberculosis in children
Few children with drug-resistant (DR) tuberculosis (TB) are identified, diagnosed, and given an appropriate treatment. The few studies that have described this vulnerable population have used inconsistent definitions. The World Health Organization (WHO) definitions used for adults with DR-TB and for children with drug-susceptible TB are not always appropriate for children with DR-TB. The Sentinel Project on Pediatric Drug-Resistant Tuberculosis was formed in 2011 as a network of experts and stakeholders in childhood DR-TB. An early priority was to establish standardized definitions for key parameters in order to facilitate study comparisons and the development of an evidence base to guide future clinical management. This consensus statement proposes standardized definitions to be used in research. In particular, it suggests consistent terminology, as well as definitions for measures of exposure, drug resistance testing, previous episodes and treatment, certainty of diagnosis, site and severity of disease, adverse events, and treatment outcome
2048-7193
100-109
Seddon, J.A.
24778705-d0ef-497b-8e62-480913c0cead
Perez-Velez, C.M.
ac499017-7d15-4db1-9865-d77ec9811652
Schaaf, H.S.
16b7ce95-af7f-4d29-85cd-0b29783805c6
Furin, J.J.
8a026f26-cd5f-4d58-9aa4-d52517887574
Marais, B.J.
dcaa6791-e6ae-43ba-9e04-f97f4076359b
Tebruegge, M.
2c3dff22-0b5f-48a7-bb36-ce323705f74a
Detjen, A.
1c09915e-541d-45f7-bb24-97f6fceade42
Hesseling, A.C.
80f41d05-ff7c-40fa-a250-abe61bc7f3c9
Shah, S.
e85242ea-3077-4d09-8fd1-cba693cb9f0d
Adams, L.V.
2870fe66-ec1c-42e4-a6ed-60364603a57f
Starke, J.R.
b701be87-ff31-431d-b70d-4b0c5c9beea0
Swaminathan, S.
5a51e86e-3e2f-4686-b9a9-c7910ce71713
Becerra, M.C.
d1f2ba1a-56ea-4039-aa64-00e73607fc16
Seddon, J.A.
24778705-d0ef-497b-8e62-480913c0cead
Perez-Velez, C.M.
ac499017-7d15-4db1-9865-d77ec9811652
Schaaf, H.S.
16b7ce95-af7f-4d29-85cd-0b29783805c6
Furin, J.J.
8a026f26-cd5f-4d58-9aa4-d52517887574
Marais, B.J.
dcaa6791-e6ae-43ba-9e04-f97f4076359b
Tebruegge, M.
2c3dff22-0b5f-48a7-bb36-ce323705f74a
Detjen, A.
1c09915e-541d-45f7-bb24-97f6fceade42
Hesseling, A.C.
80f41d05-ff7c-40fa-a250-abe61bc7f3c9
Shah, S.
e85242ea-3077-4d09-8fd1-cba693cb9f0d
Adams, L.V.
2870fe66-ec1c-42e4-a6ed-60364603a57f
Starke, J.R.
b701be87-ff31-431d-b70d-4b0c5c9beea0
Swaminathan, S.
5a51e86e-3e2f-4686-b9a9-c7910ce71713
Becerra, M.C.
d1f2ba1a-56ea-4039-aa64-00e73607fc16

Seddon, J.A., Perez-Velez, C.M., Schaaf, H.S., Furin, J.J., Marais, B.J., Tebruegge, M., Detjen, A., Hesseling, A.C., Shah, S., Adams, L.V., Starke, J.R., Swaminathan, S. and Becerra, M.C. (2013) Consensus statement on research definitions for drug-resistant tuberculosis in children. Journal of the Pediatric Infectectious Diseases Society, 2 (2), 100-109. (doi:10.1093/jpids/pit012). (PMID:23717785)

Record type: Article

Abstract

Few children with drug-resistant (DR) tuberculosis (TB) are identified, diagnosed, and given an appropriate treatment. The few studies that have described this vulnerable population have used inconsistent definitions. The World Health Organization (WHO) definitions used for adults with DR-TB and for children with drug-susceptible TB are not always appropriate for children with DR-TB. The Sentinel Project on Pediatric Drug-Resistant Tuberculosis was formed in 2011 as a network of experts and stakeholders in childhood DR-TB. An early priority was to establish standardized definitions for key parameters in order to facilitate study comparisons and the development of an evidence base to guide future clinical management. This consensus statement proposes standardized definitions to be used in research. In particular, it suggests consistent terminology, as well as definitions for measures of exposure, drug resistance testing, previous episodes and treatment, certainty of diagnosis, site and severity of disease, adverse events, and treatment outcome

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Published date: 2013
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 359633
URI: http://eprints.soton.ac.uk/id/eprint/359633
ISSN: 2048-7193
PURE UUID: 2cbda9ff-e334-4d1e-86fb-16df535a4616

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Date deposited: 08 Nov 2013 09:24
Last modified: 16 Jul 2019 21:17

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Contributors

Author: J.A. Seddon
Author: C.M. Perez-Velez
Author: H.S. Schaaf
Author: J.J. Furin
Author: B.J. Marais
Author: M. Tebruegge
Author: A. Detjen
Author: A.C. Hesseling
Author: S. Shah
Author: L.V. Adams
Author: J.R. Starke
Author: S. Swaminathan
Author: M.C. Becerra

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