Artificial airways for the study of respiratory disease
Artificial airways for the study of respiratory disease
This review will focus on human cell-based experimental models to study respiratory diseases, in particular models of the large airways relevant to asthma and chronic obstructive pulmonary disease. Such models have the advantage of incorporating cells that can be derived from disease-relevant tissue and so have retained important genetic and epigenetic features that contribute to the human disease. These models can be used for mechanistic studies, target identification and validation and toxicological testing. While many models have been developed to varying degrees of sophistication, the challenge remains to develop an integrated system that recapitulates the complex cell-cell and cell-matrix interactions that occur in vivo and to provide these with a 'circulation' to study the dynamics of immune and inflammatory cell influx and efflux.
757-765
Swindle, Emily J.
fe393c7a-a513-4de4-b02e-27369bd7e84f
Davies, D.E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
December 2011
Swindle, Emily J.
fe393c7a-a513-4de4-b02e-27369bd7e84f
Davies, D.E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Swindle, Emily J. and Davies, D.E.
(2011)
Artificial airways for the study of respiratory disease.
Expert Review of Respiratory Medicine, 5 (6), .
(doi:10.1586/ers.11.78).
(PMID:22082162)
Abstract
This review will focus on human cell-based experimental models to study respiratory diseases, in particular models of the large airways relevant to asthma and chronic obstructive pulmonary disease. Such models have the advantage of incorporating cells that can be derived from disease-relevant tissue and so have retained important genetic and epigenetic features that contribute to the human disease. These models can be used for mechanistic studies, target identification and validation and toxicological testing. While many models have been developed to varying degrees of sophistication, the challenge remains to develop an integrated system that recapitulates the complex cell-cell and cell-matrix interactions that occur in vivo and to provide these with a 'circulation' to study the dynamics of immune and inflammatory cell influx and efflux.
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Published date: December 2011
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 359872
URI: http://eprints.soton.ac.uk/id/eprint/359872
ISSN: 1747-6348
PURE UUID: c64eb793-1e4b-4d27-b6d9-7ee0f5cfab4c
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Date deposited: 15 Nov 2013 14:03
Last modified: 15 Mar 2024 03:33
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