Estradiol downregulates NF-?b translocation by Ikbkg transcriptional repression in dendritic cells
Estradiol downregulates NF-?b translocation by Ikbkg transcriptional repression in dendritic cells
To reconcile immunity and reproduction, females must allow spermatozoa to survive and control the presence of commensal microbiota and sexually transmitted pathogens during ovulation. Female steroid sex hormones exert a powerful effect on the immune system, as do the hormonal changes associated with the ovarian cycle. Dendritic cells (DCs) are immunological sentinels that link innate immunity to adaptive immunity. Upon exposure to microbial invaders in tissue, they undergo a maturational process that culminates in the lymph nodes and activates T-cell-specific immune responses. Estradiol, which is highly expressed during ovulation, has an effect on the maturation of DCs, although the molecular mechanism remains elusive. We detected that estradiol regulates expression of Ikbkg in DCs and modulates nuclear factor-?b translocation to the nucleus, thus explaining the reduced DC function observed during ovulation. This change may be an adaptive mechanism to reconcile control of infection and reproductive functions.
estradiol, NF-kb, Ikbkg, dendritic cells
462-469
Lasarte, S.
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Elsner, D.
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Sanchez-Elsner, T.
b8799f8d-e2b4-4b37-b77c-f2f0e8e2070d
Fernandez-Pineda, A.
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López-Fernández, L.A.
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Corbi, A.L.
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Muñoz-Fernandez, M.A.
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Relloso, M.
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October 2013
Lasarte, S.
db244b5f-f7ea-45e3-86e6-fc9faa5f42a6
Elsner, D.
af9e5a00-e29a-4cb2-b106-a4357e0201fc
Sanchez-Elsner, T.
b8799f8d-e2b4-4b37-b77c-f2f0e8e2070d
Fernandez-Pineda, A.
70ea880f-9761-4ba0-9005-30f510bac350
López-Fernández, L.A.
f4fabec7-88ca-47c7-b631-6d5ad35149dd
Corbi, A.L.
40b912f6-8c32-4998-acb4-9203c532021f
Muñoz-Fernandez, M.A.
6c5e6e85-b3ef-4067-be34-786acf5abb86
Relloso, M.
365d8fd4-c7b2-4f3f-8eda-1c4ace32c4c7
Lasarte, S., Elsner, D., Sanchez-Elsner, T., Fernandez-Pineda, A., López-Fernández, L.A., Corbi, A.L., Muñoz-Fernandez, M.A. and Relloso, M.
(2013)
Estradiol downregulates NF-?b translocation by Ikbkg transcriptional repression in dendritic cells.
Genes and Immunity, 14 (7), .
(doi:10.1038/gene.2013.35).
(PMID:23883819)
Abstract
To reconcile immunity and reproduction, females must allow spermatozoa to survive and control the presence of commensal microbiota and sexually transmitted pathogens during ovulation. Female steroid sex hormones exert a powerful effect on the immune system, as do the hormonal changes associated with the ovarian cycle. Dendritic cells (DCs) are immunological sentinels that link innate immunity to adaptive immunity. Upon exposure to microbial invaders in tissue, they undergo a maturational process that culminates in the lymph nodes and activates T-cell-specific immune responses. Estradiol, which is highly expressed during ovulation, has an effect on the maturation of DCs, although the molecular mechanism remains elusive. We detected that estradiol regulates expression of Ikbkg in DCs and modulates nuclear factor-?b translocation to the nucleus, thus explaining the reduced DC function observed during ovulation. This change may be an adaptive mechanism to reconcile control of infection and reproductive functions.
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Lasarte et al 2013 (Summary).pdf
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e-pub ahead of print date: 25 July 2013
Published date: October 2013
Keywords:
estradiol, NF-kb, Ikbkg, dendritic cells
Organisations:
Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 359901
URI: http://eprints.soton.ac.uk/id/eprint/359901
ISSN: 1466-4879
PURE UUID: 5b0b9752-64d4-4743-aa44-3c748ec7daa8
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Date deposited: 15 Nov 2013 14:58
Last modified: 15 Mar 2024 03:29
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Contributors
Author:
S. Lasarte
Author:
D. Elsner
Author:
A. Fernandez-Pineda
Author:
L.A. López-Fernández
Author:
A.L. Corbi
Author:
M.A. Muñoz-Fernandez
Author:
M. Relloso
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