Signaling pathways open the GAITway to translational control
Signaling pathways open the GAITway to translational control
In activated monocytes, Interferon-gamma modulates assembly of a heterotetrameric inhibitor of translation. This is responsive to signaling cascades promoting the induction and activation of death associated protein kinase (DAPK) and consequently zipper-interacting protein kinase (ZIPK). Now Mukhopadhyay et al., in a recent issue of Molecular Cell, show that the kinases themselves are regulated by the same translational silencing they promote thereby providing a negative feedback loop to limit late inflammatory gene expression.
639-640
Morley, Simon J.
059a6269-c9e5-4165-8498-238153537ceb
Willett, Mark
dfa36c04-719a-4884-87cd-2ae13a3d2b67
November 2008
Morley, Simon J.
059a6269-c9e5-4165-8498-238153537ceb
Willett, Mark
dfa36c04-719a-4884-87cd-2ae13a3d2b67
Abstract
In activated monocytes, Interferon-gamma modulates assembly of a heterotetrameric inhibitor of translation. This is responsive to signaling cascades promoting the induction and activation of death associated protein kinase (DAPK) and consequently zipper-interacting protein kinase (ZIPK). Now Mukhopadhyay et al., in a recent issue of Molecular Cell, show that the kinases themselves are regulated by the same translational silencing they promote thereby providing a negative feedback loop to limit late inflammatory gene expression.
This record has no associated files available for download.
More information
Published date: November 2008
Organisations:
Centre for Biological Sciences
Identifiers
Local EPrints ID: 360115
URI: http://eprints.soton.ac.uk/id/eprint/360115
ISSN: 1534-5807
PURE UUID: 66ffa53d-0d8a-43ff-bf46-5a9a0614933b
Catalogue record
Date deposited: 27 Nov 2013 14:04
Last modified: 14 Mar 2024 15:33
Export record
Altmetrics
Contributors
Author:
Simon J. Morley
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics