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Signaling pathways open the GAITway to translational control

Signaling pathways open the GAITway to translational control
Signaling pathways open the GAITway to translational control
In activated monocytes, Interferon-gamma modulates assembly of a heterotetrameric inhibitor of translation. This is responsive to signaling cascades promoting the induction and activation of death associated protein kinase (DAPK) and consequently zipper-interacting protein kinase (ZIPK). Now Mukhopadhyay et al., in a recent issue of Molecular Cell, show that the kinases themselves are regulated by the same translational silencing they promote thereby providing a negative feedback loop to limit late inflammatory gene expression.
1534-5807
639-640
Morley, Simon J.
059a6269-c9e5-4165-8498-238153537ceb
Willett, Mark
dfa36c04-719a-4884-87cd-2ae13a3d2b67
Morley, Simon J.
059a6269-c9e5-4165-8498-238153537ceb
Willett, Mark
dfa36c04-719a-4884-87cd-2ae13a3d2b67

Morley, Simon J. and Willett, Mark (2008) Signaling pathways open the GAITway to translational control. Developmental Cell, 15 (5), 639-640. (doi:10.1016/j.devcel.2008.10.007). (PMID:19000828)

Record type: Article

Abstract

In activated monocytes, Interferon-gamma modulates assembly of a heterotetrameric inhibitor of translation. This is responsive to signaling cascades promoting the induction and activation of death associated protein kinase (DAPK) and consequently zipper-interacting protein kinase (ZIPK). Now Mukhopadhyay et al., in a recent issue of Molecular Cell, show that the kinases themselves are regulated by the same translational silencing they promote thereby providing a negative feedback loop to limit late inflammatory gene expression.

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Published date: November 2008
Organisations: Centre for Biological Sciences

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Local EPrints ID: 360115
URI: http://eprints.soton.ac.uk/id/eprint/360115
ISSN: 1534-5807
PURE UUID: 66ffa53d-0d8a-43ff-bf46-5a9a0614933b

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Date deposited: 27 Nov 2013 14:04
Last modified: 14 Mar 2024 15:33

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Contributors

Author: Simon J. Morley
Author: Mark Willett

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