Once more into the breach: the role of the damaged bronchial epithelium in asthma
Once more into the breach: the role of the damaged bronchial epithelium in asthma
Addressing the hypothesis that epithelial damage is related to bronchial hyperreactivity, Laitinen et al. measured bronchial reactivity to inhaled histamine and took biopsies from three levels of the airway mucosa of eight adult patients with mild to severe asthma and one control subject, preparing electron micrographs from the specimens. The results showed that asthma patients can have profound airway epithelium destruction at all levels of the airway, with ciliated cells the most destroyed cell type. The authors suggest that epithelial damage is caused by asthma itself rather than medication.
9780199651559
Djukanovic, Ratko
d9a45ee7-6a80-4d84-a0ed-10962660a98d
Staples, Karl J.
e0e9d80f-0aed-435f-bd75-0c8818491fee
February 2013
Djukanovic, Ratko
d9a45ee7-6a80-4d84-a0ed-10962660a98d
Staples, Karl J.
e0e9d80f-0aed-435f-bd75-0c8818491fee
Djukanovic, Ratko and Staples, Karl J.
(2013)
Once more into the breach: the role of the damaged bronchial epithelium in asthma.
In,
Sheikh, A., Platts-Mills, T. and Worth, A.
(eds.)
Landmarks in Allergy: Seminal Papers in Allergy with Expert Commentaries.
Oxford, GB.
Oxford University Press.
(doi:10.1093/med/9780199651559.003.0056).
Record type:
Book Section
Abstract
Addressing the hypothesis that epithelial damage is related to bronchial hyperreactivity, Laitinen et al. measured bronchial reactivity to inhaled histamine and took biopsies from three levels of the airway mucosa of eight adult patients with mild to severe asthma and one control subject, preparing electron micrographs from the specimens. The results showed that asthma patients can have profound airway epithelium destruction at all levels of the airway, with ciliated cells the most destroyed cell type. The authors suggest that epithelial damage is caused by asthma itself rather than medication.
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Published date: February 2013
Organisations:
Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 360196
URI: http://eprints.soton.ac.uk/id/eprint/360196
ISBN: 9780199651559
PURE UUID: e1d0997c-6c68-4b09-9a06-3729fd8d9b24
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Date deposited: 28 Nov 2013 13:56
Last modified: 15 Mar 2024 03:27
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Contributors
Editor:
A. Sheikh
Editor:
T. Platts-Mills
Editor:
A. Worth
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