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Epigenomics and allergic disease

Epigenomics and allergic disease
Epigenomics and allergic disease
Allergic disease development is affected by both genes and the environment, and epigenetic mechanisms are hypothesized to mediate these environmental effects. In this article, we discuss the link between the environment, DNA methylation and allergic disease, as well as questions of causality inherent to analyses of DNA methylation. From the practical side, we describe characteristics of allergic phenotypes and contrast different epidemiologic study designs used in epigenetic research. We examine methodological considerations, how best to conduct preprocessing and analysis of DNA methylation data sets, and the latest methods, technologies and discoveries in this rapidly advancing field. DNA methylation and other epigenetic marks are firmly entwined with allergic disease, a link that may hold the basis for future allergic disease diagnosis and treatment.
1750-1911
685-699
Lockett, Gabrielle A.
4d92a28c-f54c-431b-81f6-e82ad9057d7a
Patil, Veeresh K.
ca29bab3-2a4d-49e0-8f15-9f2109ecdd64
Soto-Ramírez, Nelís
3526295b-e2ec-4cf3-bc74-088d10943f45
Ziyab, Ali H.
12905e44-3fd1-47c2-98e5-35320e89815b
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853
Lockett, Gabrielle A.
4d92a28c-f54c-431b-81f6-e82ad9057d7a
Patil, Veeresh K.
ca29bab3-2a4d-49e0-8f15-9f2109ecdd64
Soto-Ramírez, Nelís
3526295b-e2ec-4cf3-bc74-088d10943f45
Ziyab, Ali H.
12905e44-3fd1-47c2-98e5-35320e89815b
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853

Lockett, Gabrielle A., Patil, Veeresh K., Soto-Ramírez, Nelís, Ziyab, Ali H., Holloway, John W. and Karmaus, Wilfried (2013) Epigenomics and allergic disease. Epigenomics, 5 (6), 685-699. (doi:10.2217/epi.13.68).

Record type: Article

Abstract

Allergic disease development is affected by both genes and the environment, and epigenetic mechanisms are hypothesized to mediate these environmental effects. In this article, we discuss the link between the environment, DNA methylation and allergic disease, as well as questions of causality inherent to analyses of DNA methylation. From the practical side, we describe characteristics of allergic phenotypes and contrast different epidemiologic study designs used in epigenetic research. We examine methodological considerations, how best to conduct preprocessing and analysis of DNA methylation data sets, and the latest methods, technologies and discoveries in this rapidly advancing field. DNA methylation and other epigenetic marks are firmly entwined with allergic disease, a link that may hold the basis for future allergic disease diagnosis and treatment.

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More information

Published date: December 2013
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 360222
URI: http://eprints.soton.ac.uk/id/eprint/360222
ISSN: 1750-1911
PURE UUID: c26c3057-38d5-4e3c-819f-2d576d7067cc
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

Catalogue record

Date deposited: 29 Nov 2013 14:17
Last modified: 02 Aug 2023 01:39

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Contributors

Author: Gabrielle A. Lockett
Author: Veeresh K. Patil
Author: Nelís Soto-Ramírez
Author: Ali H. Ziyab
Author: Wilfried Karmaus

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