Three-component diastereoselective cascade synthesis of thiohydantoins

Ceban, Victor, Hands, Kane, Meazza, Marta, Light, Mark E. and Rios, Ramon (2013) Three-component diastereoselective cascade synthesis of thiohydantoins. Tetrahedron Letters, 54 (52), 7183-7187. (doi:10.1016/j.tetlet.2013.10.110).

Record type: Article

Abstract

A new three-component cascade reaction for the synthesis of thiohydantoins is reported. The reaction between ?-amino esters, nitrostyrenes, and aromatic isothiocyanates is efficiently promoted by organic bases to afford highly substituted thiohydantoins in moderate to good yields and diastereoselectivities.

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Accepted/In Press date: 23 October 2013

e-pub ahead of print date: 1 November 2013

Keywords: organocatalysis, cascade reactions, thiohydantoins, edman degradation, diastereoselective

Organisations: Organic Chemistry: Synthesis, Catalysis and Flow, Chemistry, Faculty of Natural and Environmental Sciences

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Identifiers

Local EPrints ID: 360395

URI: http://eprints.soton.ac.uk/id/eprint/360395

DOI: doi:10.1016/j.tetlet.2013.10.110

ISSN: 0040-4039

PURE UUID: 3e1bc2f9-af96-4943-a131-371de00a9d15

ORCID for Marta Meazza:

orcid.org/0000-0003-4382-0626

ORCID for Mark E. Light:

orcid.org/0000-0002-0585-0843

ORCID for Ramon Rios:

orcid.org/0000-0002-3843-8521

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Date deposited: 06 Dec 2013 13:08

Last modified: 15 Mar 2024 03:01

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Contributors

Author: Victor Ceban

Author: Kane Hands

Author: Marta Meazza

Author: Mark E. Light

Author: Ramon Rios

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