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Inflammatory markers and incident frailty in men and women: the English Longitudinal Study of Ageing

Inflammatory markers and incident frailty in men and women: the English Longitudinal Study of Ageing
Inflammatory markers and incident frailty in men and women: the English Longitudinal Study of Ageing
Cross-sectional studies show that higher blood concentrations of inflammatory markers tend to be more common in frail older people, but longitudinal evidence that these inflammatory markers are risk factors for frailty is sparse and inconsistent. We investigated the prospective relation between baseline concentrations of the inflammatory markers C-reactive protein (CRP) and fibrinogen and risk of incident frailty in 2,146 men and women aged 60 to over 90 years from the English Longitudinal Study of Ageing. The relationship between CRP and fibrinogen and risk of incident frailty differed significantly by sex (p for interaction terms <0.05). In age-adjusted logistic regression analyses, for a standard deviation (SD) increase in CRP or fibrinogen, odds ratios (95 % confidence intervals) for incident frailty in women were 1.69 (1.32, 2.17) and 1.39 (1.12, 1.72), respectively. Further adjustment for other potential confounding factors attenuated both these estimates. For an SD increase in CRP and fibrinogen, the fully-adjusted odds ratio (95 % confidence interval) for incident frailty in women was 1.27 (0.96, 1.69) and 1.31 (1.04, 1.67), respectively. Having a high concentration of both inflammatory markers was more strongly predictive of incident frailty than having a high concentration of either marker alone. In men, there were no significant associations between any of the inflammatory markers and risk of incident frailty. High concentrations of the inflammatory markers CRP and fibrinogen are more strongly predictive of incident frailty in women than in men. Further research is needed to understand the mechanisms underlying this sex difference.
0161-9152
2493-2501
Gale, Catharine R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Baylis, Daniel
eafafa34-ac61-4082-9355-6aba3d7f738c
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Sayer, Avan Aihie
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Gale, Catharine R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Baylis, Daniel
eafafa34-ac61-4082-9355-6aba3d7f738c
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Sayer, Avan Aihie
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb

Gale, Catharine R., Baylis, Daniel, Cooper, Cyrus and Sayer, Avan Aihie (2013) Inflammatory markers and incident frailty in men and women: the English Longitudinal Study of Ageing. Age, 35 (6), 2493-2501. (doi:10.1007/s11357-013-9528-9). (PMID:23543263)

Record type: Article

Abstract

Cross-sectional studies show that higher blood concentrations of inflammatory markers tend to be more common in frail older people, but longitudinal evidence that these inflammatory markers are risk factors for frailty is sparse and inconsistent. We investigated the prospective relation between baseline concentrations of the inflammatory markers C-reactive protein (CRP) and fibrinogen and risk of incident frailty in 2,146 men and women aged 60 to over 90 years from the English Longitudinal Study of Ageing. The relationship between CRP and fibrinogen and risk of incident frailty differed significantly by sex (p for interaction terms <0.05). In age-adjusted logistic regression analyses, for a standard deviation (SD) increase in CRP or fibrinogen, odds ratios (95 % confidence intervals) for incident frailty in women were 1.69 (1.32, 2.17) and 1.39 (1.12, 1.72), respectively. Further adjustment for other potential confounding factors attenuated both these estimates. For an SD increase in CRP and fibrinogen, the fully-adjusted odds ratio (95 % confidence interval) for incident frailty in women was 1.27 (0.96, 1.69) and 1.31 (1.04, 1.67), respectively. Having a high concentration of both inflammatory markers was more strongly predictive of incident frailty than having a high concentration of either marker alone. In men, there were no significant associations between any of the inflammatory markers and risk of incident frailty. High concentrations of the inflammatory markers CRP and fibrinogen are more strongly predictive of incident frailty in women than in men. Further research is needed to understand the mechanisms underlying this sex difference.

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e-pub ahead of print date: 2 April 2013
Published date: December 2013
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 360432
URI: http://eprints.soton.ac.uk/id/eprint/360432
ISSN: 0161-9152
PURE UUID: bc13e0a4-b9ea-41be-a29f-0fe22b247491
ORCID for Catharine R. Gale: ORCID iD orcid.org/0000-0002-3361-8638
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 09 Dec 2013 14:54
Last modified: 18 Feb 2021 16:48

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Author: Daniel Baylis
Author: Cyrus Cooper ORCID iD
Author: Avan Aihie Sayer

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