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Lipoprotein (a), metabolic syndrome and coronary calcium score in a large occupational cohort

Lipoprotein (a), metabolic syndrome and coronary calcium score in a large occupational cohort
Lipoprotein (a), metabolic syndrome and coronary calcium score in a large occupational cohort
BACKGROUND AND AIMS: Whether lipoprotein (a) [Lp(a)] concentration is associated with metabolic syndrome (MetS) and pre-clinical atherosclerosis in different ethnic groups is uncertain. The association between Lp(a), MetS and a measure of pre-clinical atherosclerosis was studied in a large Asian cohort.

METHODS AND RESULTS: Data were analyzed from a South Korean occupational cohort who underwent a cardiac computed tomography (CT) estimation of CAC score and measurements of cardiovascular risk factors (n = 14,583 people). The key exposure was an Lp(a) concentration in the top quartile (>38.64 mg/dL)) with a CAC score >0 as the outcome variable and measure of pre-clinical atherosclerosis. Logistic regression was used to describe the associations. 1462 participants had a CAC score >0. In the lowest Lp(a) quartile (<11.29 mg/dL), 25.8% had MetS, compared with 16.1% in the highest Lp(a) quartile (>38.64 mg/dL (p < 0.001). MetS, and component features, were inversely related to Lp(a) concentration (all p < 0.0001). In the highest Lp(a) quartile group, there was an association between Lp(a) and CAC score >0 in men (OR 1.21[1.05, 1.40], p = 0.008), and women (OR 1.62[1.03, 2.55], p = 0.038), after adjustment for age, sex, lipid lowering therapy, and multiple cardiovascular risk factors. There was no evidence of an interaction between highest quartile Lp(a) and either high LDLc (>147 mg/dL) (p = 0.99), or MetS (p = 0.84) on the association with CAC score >0.

CONCLUSION: Lp(a) levels are inversely related to MetS and its components. There was a robust association between Lp(a) concentration >38.6 mg/dL and marker of early atherosclerosis in both men and women, regardless of LDLc, level MetS or other cardiovascular risk factors.
Lp(a), coronary artery calcium (CAC) score, atherosclerosis, cardio-metabolic risk factors, cardiovascular disease (CVD), metabolic syndrome(MetS)
1590-3729
1239-1246
Sung, K.-C.
fd4c087c-3466-4c9a-aa95-cb1f07ad8e56
Wild, S.H.
eb23a87e-b8da-4f3f-8dab-e02e7b5104aa
Byrne, C.D.
1370b997-cead-4229-83a7-53301ed2a43c
Sung, K.-C.
fd4c087c-3466-4c9a-aa95-cb1f07ad8e56
Wild, S.H.
eb23a87e-b8da-4f3f-8dab-e02e7b5104aa
Byrne, C.D.
1370b997-cead-4229-83a7-53301ed2a43c

Sung, K.-C., Wild, S.H. and Byrne, C.D. (2013) Lipoprotein (a), metabolic syndrome and coronary calcium score in a large occupational cohort. Nutrition, Metabolism and Cardiovascular Diseases, 23 (12), 1239-1246. (doi:10.1016/j.numecd.2013.02.009). (PMID:23786824)

Record type: Article

Abstract

BACKGROUND AND AIMS: Whether lipoprotein (a) [Lp(a)] concentration is associated with metabolic syndrome (MetS) and pre-clinical atherosclerosis in different ethnic groups is uncertain. The association between Lp(a), MetS and a measure of pre-clinical atherosclerosis was studied in a large Asian cohort.

METHODS AND RESULTS: Data were analyzed from a South Korean occupational cohort who underwent a cardiac computed tomography (CT) estimation of CAC score and measurements of cardiovascular risk factors (n = 14,583 people). The key exposure was an Lp(a) concentration in the top quartile (>38.64 mg/dL)) with a CAC score >0 as the outcome variable and measure of pre-clinical atherosclerosis. Logistic regression was used to describe the associations. 1462 participants had a CAC score >0. In the lowest Lp(a) quartile (<11.29 mg/dL), 25.8% had MetS, compared with 16.1% in the highest Lp(a) quartile (>38.64 mg/dL (p < 0.001). MetS, and component features, were inversely related to Lp(a) concentration (all p < 0.0001). In the highest Lp(a) quartile group, there was an association between Lp(a) and CAC score >0 in men (OR 1.21[1.05, 1.40], p = 0.008), and women (OR 1.62[1.03, 2.55], p = 0.038), after adjustment for age, sex, lipid lowering therapy, and multiple cardiovascular risk factors. There was no evidence of an interaction between highest quartile Lp(a) and either high LDLc (>147 mg/dL) (p = 0.99), or MetS (p = 0.84) on the association with CAC score >0.

CONCLUSION: Lp(a) levels are inversely related to MetS and its components. There was a robust association between Lp(a) concentration >38.6 mg/dL and marker of early atherosclerosis in both men and women, regardless of LDLc, level MetS or other cardiovascular risk factors.

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More information

e-pub ahead of print date: 17 June 2013
Published date: December 2013
Keywords: Lp(a), coronary artery calcium (CAC) score, atherosclerosis, cardio-metabolic risk factors, cardiovascular disease (CVD), metabolic syndrome(MetS)
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 360775
URI: http://eprints.soton.ac.uk/id/eprint/360775
ISSN: 1590-3729
PURE UUID: af4293c1-b876-41d5-94b9-04b1bf4d4b70
ORCID for C.D. Byrne: ORCID iD orcid.org/0000-0001-6322-7753

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Date deposited: 02 Jan 2014 14:36
Last modified: 23 Jul 2022 01:45

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Contributors

Author: K.-C. Sung
Author: S.H. Wild
Author: C.D. Byrne ORCID iD

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