Intensive glucose control and hypoglycaemia: a new cardiovascular risk factor?
Intensive glucose control and hypoglycaemia: a new cardiovascular risk factor?
Intensive glucose control is widely practiced in patients with diabetes mellitus and patients acutely admitted to hospitals with concomitant stress-induced hyperglycaemia. Such a strategy increases the risk of hypoglycaemia by several-fold. Hypoglycaemia leads to a surge in catecholamine levels with a profound haemodynamic response. In patients with a decreased cardiac reserve, such significant changes can culminate in serious or even fatal cardiovascular outcomes. This review is aimed at discussing in depth the evidence to date that links hypoglycaemia with cardiovascular mortality, reviewing the likely mechanisms underlying this association, as well as summarising these from a cardiologist's perspective.
21-27
Rana, Omar A.
0374dc78-54b9-4a79-94b6-69447bf1a52e
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Greaves, Kim
176a04cc-a3b0-451d-9d2e-59db4cde71c7
1 January 2014
Rana, Omar A.
0374dc78-54b9-4a79-94b6-69447bf1a52e
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Greaves, Kim
176a04cc-a3b0-451d-9d2e-59db4cde71c7
Abstract
Intensive glucose control is widely practiced in patients with diabetes mellitus and patients acutely admitted to hospitals with concomitant stress-induced hyperglycaemia. Such a strategy increases the risk of hypoglycaemia by several-fold. Hypoglycaemia leads to a surge in catecholamine levels with a profound haemodynamic response. In patients with a decreased cardiac reserve, such significant changes can culminate in serious or even fatal cardiovascular outcomes. This review is aimed at discussing in depth the evidence to date that links hypoglycaemia with cardiovascular mortality, reviewing the likely mechanisms underlying this association, as well as summarising these from a cardiologist's perspective.
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e-pub ahead of print date: 22 May 2013
Published date: 1 January 2014
Organisations:
Human Development & Health
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Local EPrints ID: 360794
URI: http://eprints.soton.ac.uk/id/eprint/360794
PURE UUID: 7186672e-7c75-4a84-b0b5-57ffd4727d52
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Date deposited: 02 Jan 2014 14:55
Last modified: 15 Mar 2024 03:02
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Author:
Omar A. Rana
Author:
Kim Greaves
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