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Investigating the flow dynamics in the obstructed and stented ureter by means of a biomimetic artificial model

Investigating the flow dynamics in the obstructed and stented ureter by means of a biomimetic artificial model
Investigating the flow dynamics in the obstructed and stented ureter by means of a biomimetic artificial model
Double-J stenting is the most common clinical method employed to restore the upper urinary tract drainage, in the presence of a ureteric obstruction. After implant, stents provide an immediate pain relief by decreasing the pressure in the renal pelvis (P). However, their long-term usage can cause infections and encrustations, due to bacterial colonization and crystal deposition on the stent surface, respectively. The performance of double-J stents - and in general of all ureteric stents - is thought to depend significantly on urine flow field within the stented ureter. However very little fundamental research about the role played by fluid dynamic parameters on stent functionality has been conducted so far. These parameters are often difficult to assess in-vivo, requiring the implementation of laborious and expensive experimental protocols. The aim of the present work was therefore to develop an artificial model of the ureter (i.e. ureter model, UM) to mimic the fluid dynamic environment in a stented ureter. The UM was designed to reflect the geometry of pig ureters, and to investigate the values of fluid dynamic viscosity (?), volumetric flow rate (Q) and severity of ureteric obstruction (OB%) which may cause critical pressures in the renal pelvis. The distributed obstruction derived by the sole stent insertion was also quantified. In addition, flow visualisation experiments and computational simulations were performed in order to further characterise the flow field in the UM. Unique characteristics of the flow dynamics in the obstructed and stented ureter have been revealed with using the developed UM.
1932-6203
Clavica, Francesco
5b484bb7-1299-4c21-a7c8-b216b3d3b2e5
Zhao, Xuefeng
5b7a35ab-f71e-4625-80e2-676c4a15533a
ElMahdy, Motaz
f41a3c77-2929-4467-ae37-5122d22f5c7a
Drake, Marcus
a956bb01-b0d2-4806-ae04-f56c0ab1096a
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Clavica, Francesco
5b484bb7-1299-4c21-a7c8-b216b3d3b2e5
Zhao, Xuefeng
5b7a35ab-f71e-4625-80e2-676c4a15533a
ElMahdy, Motaz
f41a3c77-2929-4467-ae37-5122d22f5c7a
Drake, Marcus
a956bb01-b0d2-4806-ae04-f56c0ab1096a
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179

Clavica, Francesco, Zhao, Xuefeng, ElMahdy, Motaz, Drake, Marcus, Zhang, Xunli and Carugo, Dario (2014) Investigating the flow dynamics in the obstructed and stented ureter by means of a biomimetic artificial model. PLoS ONE, 9 (2), [e87433]. (doi:10.1371/journal.pone.0087433).

Record type: Article

Abstract

Double-J stenting is the most common clinical method employed to restore the upper urinary tract drainage, in the presence of a ureteric obstruction. After implant, stents provide an immediate pain relief by decreasing the pressure in the renal pelvis (P). However, their long-term usage can cause infections and encrustations, due to bacterial colonization and crystal deposition on the stent surface, respectively. The performance of double-J stents - and in general of all ureteric stents - is thought to depend significantly on urine flow field within the stented ureter. However very little fundamental research about the role played by fluid dynamic parameters on stent functionality has been conducted so far. These parameters are often difficult to assess in-vivo, requiring the implementation of laborious and expensive experimental protocols. The aim of the present work was therefore to develop an artificial model of the ureter (i.e. ureter model, UM) to mimic the fluid dynamic environment in a stented ureter. The UM was designed to reflect the geometry of pig ureters, and to investigate the values of fluid dynamic viscosity (?), volumetric flow rate (Q) and severity of ureteric obstruction (OB%) which may cause critical pressures in the renal pelvis. The distributed obstruction derived by the sole stent insertion was also quantified. In addition, flow visualisation experiments and computational simulations were performed in order to further characterise the flow field in the UM. Unique characteristics of the flow dynamics in the obstructed and stented ureter have been revealed with using the developed UM.

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More information

Accepted/In Press date: 23 December 2013
e-pub ahead of print date: 3 February 2014
Published date: 3 February 2014
Organisations: Bioengineering Group, Mechatronics

Identifiers

Local EPrints ID: 360811
URI: http://eprints.soton.ac.uk/id/eprint/360811
ISSN: 1932-6203
PURE UUID: 0cf62a32-e8d8-4ec7-a218-06118263e11e
ORCID for Xunli Zhang: ORCID iD orcid.org/0000-0002-4375-1571

Catalogue record

Date deposited: 06 Jan 2014 11:52
Last modified: 24 Mar 2020 01:29

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