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Activation of the bone-derived latent TGF beta complex by isolated osteoclasts

Activation of the bone-derived latent TGF beta complex by isolated osteoclasts
Activation of the bone-derived latent TGF beta complex by isolated osteoclasts
Although TGF beta is unquestionably an important growth regulatory polypeptide with effects on many cell types, the cellular mechanisms which release it from the binding proteins which mask its biological activity are not well understood. Here we show that when isolated osteoclasts are activated, they release active TGF beta from the latent TGF beta complex produced by bone organ cultures. Since active TGF beta has powerful inhibitory effects on osteoclast formation and bone resorption and stimulates osteoblast activity, is present in abundant amounts in the bone matrix and is released during hormone-stimulated osteoclastic bone resorption, the activation of TGF beta by stimulated osteoclasts may be an important regulatory step in normal bone remodeling.
0006-291X
817-823
Oreffo, R.O.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Mundy, G.R.
921d7037-eb6c-48bb-97a0-52d2647ccfda
Seyedin, S.M.
104114d1-02ad-4f91-ace0-08195044d306
Bonewald, L.F.
eba5037e-a9b4-43b7-b262-55e0d41ede2d
Oreffo, R.O.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Mundy, G.R.
921d7037-eb6c-48bb-97a0-52d2647ccfda
Seyedin, S.M.
104114d1-02ad-4f91-ace0-08195044d306
Bonewald, L.F.
eba5037e-a9b4-43b7-b262-55e0d41ede2d

(1989) Activation of the bone-derived latent TGF beta complex by isolated osteoclasts. Biochemical and Biophysical Research Communications, 158 (3), 817-823. (doi:10.1016/0006-291X(89)92795-2). (PMID:2920041)

Record type: Article

Abstract

Although TGF beta is unquestionably an important growth regulatory polypeptide with effects on many cell types, the cellular mechanisms which release it from the binding proteins which mask its biological activity are not well understood. Here we show that when isolated osteoclasts are activated, they release active TGF beta from the latent TGF beta complex produced by bone organ cultures. Since active TGF beta has powerful inhibitory effects on osteoclast formation and bone resorption and stimulates osteoblast activity, is present in abundant amounts in the bone matrix and is released during hormone-stimulated osteoclastic bone resorption, the activation of TGF beta by stimulated osteoclasts may be an important regulatory step in normal bone remodeling.

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Published date: 15 February 1989
Organisations: Human Development & Health

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Local EPrints ID: 360849
URI: http://eprints.soton.ac.uk/id/eprint/360849
ISSN: 0006-291X
PURE UUID: cb080381-a5f6-46d9-a099-e4b3ea8b49e1
ORCID for R.O. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

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Date deposited: 08 Jan 2014 15:40
Last modified: 06 Jun 2018 12:53

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Contributors

Author: R.O. Oreffo ORCID iD
Author: G.R. Mundy
Author: S.M. Seyedin
Author: L.F. Bonewald

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