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Effect of maternal glycemia on neonatal adiposity in a multiethnic asian birth cohort

Effect of maternal glycemia on neonatal adiposity in a multiethnic asian birth cohort
Effect of maternal glycemia on neonatal adiposity in a multiethnic asian birth cohort
Context:
Gestational hyperglycemia increases the risk of obesity and diabetes in offspring later in life.

Objective:
We examined the relationship between gestational glycemia and neonatal adiposity in a multiethnic cohort of Singaporean neonates.

Design:
A prospective mother-offspring cohort study recruited 1247 pregnant mothers (57.2% Chinese, 25.5% Malay, 17.3% Indian) and performed 75-g, 2-hour oral glucose tolerance tests at 26–28 weeks' gestation; glucose levels were available for 1081 participants. Neonatal anthropometry (birth weight, length, triceps, and subscapular skinfolds) was measured, and percentage body fat (%BF) was derived using our published equation. Associations of maternal glucose with excessive neonatal adiposity [large for gestational age; %BF; and sum of skinfolds (?SFT) > 90th centile] were assessed using multiple logistic regression analyses.

Results:
Adjusting for potential confounders we observed strong positive continuous associations across the range of maternal fasting and 2-hour glucose in relation to excessive neonatal adiposity; each 1 SD increase in fasting glucose was associated with 1.31 [95% confidence interval (CI) 1.10–1.55], 1.72 (95% CI 1.31–2.27) and 1.64 (95% CI 1.32–2.03) increases in odds ratios for large for gestational age and %BF and ?SFT greater than the 90th centile, respectively. Corresponding odds ratios for 2-hour glucose were 1.11 (95% CI 0.92–1.33), 1.55 (95% CI 1.10–2.20), and 1.40 (95% CI 1.10–1.79), respectively. The influence of high maternal fasting glucose on neonatal ?SFT was less pronounced in Indians compared with Chinese (interaction P = .005).

Conclusions:
A continuous relationship between maternal glycemia and excessive neonatal adiposity extends across the range of maternal glycemia. Compared with Chinese infants, Indian infants may be less susceptible to excessive adiposity from high maternal glucose levels.
0021-972X
240-247
Aris, I.M.
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Soh, S.E.
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Tint, M.T.
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Liang, S.
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Chinnadurai, A.
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Saw, S.M.
0684517e-f27e-49f0-98c3-7630e8fd1bbd
Rajadurai, V.S.
3b5f8939-462c-4200-9146-a600d4e2e62a
Kwek, K.
1a9b6c6e-a5e9-40a2-9bfe-44c2cea62a98
Meaney, M.J.
cb875853-8497-4382-9aff-739714aa49f9
Godfrey, K.M.
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Gluckman, P.D.
492295c0-ef71-4871-ad5a-771c98e1059a
Yap, F.K.
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Chong, Y.S.
b50c99c9-4d83-46c5-a1c7-23f9a553ab8a
Lee, Y.S.
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Aris, I.M.
ee15a46e-ead3-4b4a-a208-d39038a85480
Soh, S.E.
00a5ad13-4c5b-4fad-aaa9-d080d9aa63e8
Tint, M.T.
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Liang, S.
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Chinnadurai, A.
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Saw, S.M.
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Rajadurai, V.S.
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Kwek, K.
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Meaney, M.J.
cb875853-8497-4382-9aff-739714aa49f9
Godfrey, K.M.
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Gluckman, P.D.
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Yap, F.K.
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Chong, Y.S.
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Lee, Y.S.
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Aris, I.M., Soh, S.E., Tint, M.T., Liang, S., Chinnadurai, A., Saw, S.M., Rajadurai, V.S., Kwek, K., Meaney, M.J., Godfrey, K.M., Gluckman, P.D., Yap, F.K., Chong, Y.S. and Lee, Y.S. (2014) Effect of maternal glycemia on neonatal adiposity in a multiethnic asian birth cohort. Journal of Clinical Endocrinology & Metabolism, 99 (1), 240-247. (doi:10.1210/jc.2013-2738). (PMID:24243635)

Record type: Article

Abstract

Context:
Gestational hyperglycemia increases the risk of obesity and diabetes in offspring later in life.

Objective:
We examined the relationship between gestational glycemia and neonatal adiposity in a multiethnic cohort of Singaporean neonates.

Design:
A prospective mother-offspring cohort study recruited 1247 pregnant mothers (57.2% Chinese, 25.5% Malay, 17.3% Indian) and performed 75-g, 2-hour oral glucose tolerance tests at 26–28 weeks' gestation; glucose levels were available for 1081 participants. Neonatal anthropometry (birth weight, length, triceps, and subscapular skinfolds) was measured, and percentage body fat (%BF) was derived using our published equation. Associations of maternal glucose with excessive neonatal adiposity [large for gestational age; %BF; and sum of skinfolds (?SFT) > 90th centile] were assessed using multiple logistic regression analyses.

Results:
Adjusting for potential confounders we observed strong positive continuous associations across the range of maternal fasting and 2-hour glucose in relation to excessive neonatal adiposity; each 1 SD increase in fasting glucose was associated with 1.31 [95% confidence interval (CI) 1.10–1.55], 1.72 (95% CI 1.31–2.27) and 1.64 (95% CI 1.32–2.03) increases in odds ratios for large for gestational age and %BF and ?SFT greater than the 90th centile, respectively. Corresponding odds ratios for 2-hour glucose were 1.11 (95% CI 0.92–1.33), 1.55 (95% CI 1.10–2.20), and 1.40 (95% CI 1.10–1.79), respectively. The influence of high maternal fasting glucose on neonatal ?SFT was less pronounced in Indians compared with Chinese (interaction P = .005).

Conclusions:
A continuous relationship between maternal glycemia and excessive neonatal adiposity extends across the range of maternal glycemia. Compared with Chinese infants, Indian infants may be less susceptible to excessive adiposity from high maternal glucose levels.

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More information

e-pub ahead of print date: 15 November 2013
Published date: January 2014
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 360995
URI: http://eprints.soton.ac.uk/id/eprint/360995
ISSN: 0021-972X
PURE UUID: 121ad771-056e-4211-ac38-77b1b2a904d3
ORCID for K.M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 14 Jan 2014 11:34
Last modified: 07 Oct 2020 01:35

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Contributors

Author: I.M. Aris
Author: S.E. Soh
Author: M.T. Tint
Author: S. Liang
Author: A. Chinnadurai
Author: S.M. Saw
Author: V.S. Rajadurai
Author: K. Kwek
Author: M.J. Meaney
Author: K.M. Godfrey ORCID iD
Author: P.D. Gluckman
Author: F.K. Yap
Author: Y.S. Chong
Author: Y.S. Lee

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