Lessons learnt recruiting to a multi-site UK cohort study to explore recovery of health and well-being after colorectal cancer (CREW study)
Lessons learnt recruiting to a multi-site UK cohort study to explore recovery of health and well-being after colorectal cancer (CREW study)
Background: the UK leads the world in recruitment of patients to cancer clinical trials, with a six-fold increase in recruitment during 2001–2010. However, there are large variations across cancer centres. This paper details recruitment to a large multi-centre prospective cohort study and discusses lessons learnt to enhance recruitment.
Methods: during CREW (ColoREctal Wellbeing) cohort study set up and recruitment, data were systematically collected on all centres that applied to participate, time from study approval to first participant recruited and the percentage of eligible patients recruited into the study.
Results: 30 participating NHS cancer centres were selected through an open competition via the cancer networks. Time from study approval to first participant recruited took a median 124 days (min 53, max 290). Of 1350 eligible people in the study time frame, 78% (n?=?1056) were recruited into the study, varying from 30-100% eligible across centres. Recruitment of 1056 participants took 17 months.
Conclusion: in partnership with the National Cancer Research Network, this successful study prioritised relationship building and education. Key points for effective recruitment: pre-screening and selection of centres; nurses as PIs; attendance at study days; frequent communication and a reduced level of consent to enhance uptake amongst underrepresented groups
153-153
Fenlon, D.
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Chivers Seymour, K.
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Okamoto, I.
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Winter, J.
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Richardson, A.
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Addington-Hall, J.
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Corner, J.
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Smith, P.W.
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May, C.
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Breckons, M.
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Foster, C.
00786ac1-bd47-4aeb-a0e2-40e058695b73
2013
Fenlon, D.
52f9a9f1-1643-449c-9856-258ef563342c
Chivers Seymour, K.
69d77553-6dd6-461b-a174-b604ccf44ec2
Okamoto, I.
fc9b4fed-0c78-4925-9e6f-2bfa7c3d48bc
Winter, J.
ad57c122-43c1-48cb-a902-398f563ad437
Richardson, A.
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Addington-Hall, J.
87560cc4-7562-4f9b-b908-81f3b603fdd8
Corner, J.
eddc9d69-aa12-4de5-8ab0-b20a6b5765fa
Smith, P.W.
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May, C.
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Breckons, M.
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Foster, C.
00786ac1-bd47-4aeb-a0e2-40e058695b73
Fenlon, D., Chivers Seymour, K., Okamoto, I., Winter, J., Richardson, A., Addington-Hall, J., Corner, J., Smith, P.W., May, C., Breckons, M. and Foster, C.
(2013)
Lessons learnt recruiting to a multi-site UK cohort study to explore recovery of health and well-being after colorectal cancer (CREW study).
BMC Medical Research Methodology, 13 (153), .
(doi:10.1186/1471-2288-13-153).
Abstract
Background: the UK leads the world in recruitment of patients to cancer clinical trials, with a six-fold increase in recruitment during 2001–2010. However, there are large variations across cancer centres. This paper details recruitment to a large multi-centre prospective cohort study and discusses lessons learnt to enhance recruitment.
Methods: during CREW (ColoREctal Wellbeing) cohort study set up and recruitment, data were systematically collected on all centres that applied to participate, time from study approval to first participant recruited and the percentage of eligible patients recruited into the study.
Results: 30 participating NHS cancer centres were selected through an open competition via the cancer networks. Time from study approval to first participant recruited took a median 124 days (min 53, max 290). Of 1350 eligible people in the study time frame, 78% (n?=?1056) were recruited into the study, varying from 30-100% eligible across centres. Recruitment of 1056 participants took 17 months.
Conclusion: in partnership with the National Cancer Research Network, this successful study prioritised relationship building and education. Key points for effective recruitment: pre-screening and selection of centres; nurses as PIs; attendance at study days; frequent communication and a reduced level of consent to enhance uptake amongst underrepresented groups
Text
art_10.1186_1471-2288-13-153.pdf
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Accepted/In Press date: 18 December 2013
Published date: 2013
Organisations:
Faculty of Health Sciences, Centre for Biological Sciences
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Local EPrints ID: 361035
URI: http://eprints.soton.ac.uk/id/eprint/361035
ISSN: 1471-2288
PURE UUID: 195ceb80-f6aa-4da9-a300-1b95137f835a
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Date deposited: 10 Jan 2014 16:25
Last modified: 15 Mar 2024 03:34
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Contributors
Author:
D. Fenlon
Author:
K. Chivers Seymour
Author:
I. Okamoto
Author:
J. Winter
Author:
J. Corner
Author:
C. May
Author:
M. Breckons
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