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Phase contrast tomography: an alternative approach

Phase contrast tomography: an alternative approach
Phase contrast tomography: an alternative approach
Conventional microtomography is widely used for reconstructing the three-dimensional (3D) distribution of the absorption coefficient of a sample from a set of radiographic projections. The question here is whether the 3D distribution of the phase (refractive index) of a weakly absorbing object can be, alternatively to the combined phase retrieval-backprojection methods presented up to now, directly reconstructed from a single tomographic data set. In this letter a solution to this problem based on a direct filtered backprojection approach, derived from the transport of intensity equation, is investigated numerically and experimentally for monochromatic and polychromatic x rays. The results show that the contrast is increased, while keeping dose minimal and spatial resolution equivalent to the conventional absorption based technique. This method is therefore very promising for imaging of biological specimens.
0003-6951
1-4
Groso, Amela
a5384b74-413a-4a95-bf7e-bfc7f1c44d98
Stampanoni, Marco
bfedb3b0-01e8-4e1b-9163-41295b4ceeb1
Abela, Rafael
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Schneider, Philipp
a810f925-4808-44e4-8a4a-a51586f9d7ad
Linga, Srujan
694380eb-daba-448c-9acc-cad7b3e335c3
Müller, Ralph
af17ce96-6fc3-4d3a-8e0f-093d68f36192
Groso, Amela
a5384b74-413a-4a95-bf7e-bfc7f1c44d98
Stampanoni, Marco
bfedb3b0-01e8-4e1b-9163-41295b4ceeb1
Abela, Rafael
32050843-84a9-496b-bf7a-eb495e6a71df
Schneider, Philipp
a810f925-4808-44e4-8a4a-a51586f9d7ad
Linga, Srujan
694380eb-daba-448c-9acc-cad7b3e335c3
Müller, Ralph
af17ce96-6fc3-4d3a-8e0f-093d68f36192

Groso, Amela, Stampanoni, Marco, Abela, Rafael, Schneider, Philipp, Linga, Srujan and Müller, Ralph (2006) Phase contrast tomography: an alternative approach. Applied Physics Letters, 88 (21), 1-4. (doi:10.1063/1.2207221).

Record type: Article

Abstract

Conventional microtomography is widely used for reconstructing the three-dimensional (3D) distribution of the absorption coefficient of a sample from a set of radiographic projections. The question here is whether the 3D distribution of the phase (refractive index) of a weakly absorbing object can be, alternatively to the combined phase retrieval-backprojection methods presented up to now, directly reconstructed from a single tomographic data set. In this letter a solution to this problem based on a direct filtered backprojection approach, derived from the transport of intensity equation, is investigated numerically and experimentally for monochromatic and polychromatic x rays. The results show that the contrast is increased, while keeping dose minimal and spatial resolution equivalent to the conventional absorption based technique. This method is therefore very promising for imaging of biological specimens.

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Published date: 25 May 2006
Organisations: Faculty of Engineering and the Environment

Identifiers

Local EPrints ID: 361054
URI: http://eprints.soton.ac.uk/id/eprint/361054
ISSN: 0003-6951
PURE UUID: 411b2010-c5e4-4b02-8f9d-7ff31a1f3220
ORCID for Philipp Schneider: ORCID iD orcid.org/0000-0001-7499-3576

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Date deposited: 14 Jan 2014 12:21
Last modified: 17 Dec 2019 01:36

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Contributors

Author: Amela Groso
Author: Marco Stampanoni
Author: Rafael Abela
Author: Srujan Linga
Author: Ralph Müller

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