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Preparation and characterization of calibration standards for bone density determination by micro-computed tomography

Preparation and characterization of calibration standards for bone density determination by micro-computed tomography
Preparation and characterization of calibration standards for bone density determination by micro-computed tomography
Phantoms for the calibration of local bone mineral densities by micro-computed tomography (?CT), consisting of lithium tetraborate (Li(2)B(4)O(7)) with increasing concentrations of hydroxyapatite [HAp, Ca(10)(PO(4))(6)(OH)(2)] have been prepared and characterized for homogeneity. Large-scale homogeneity and concentration of HAp in the phantom materials was determined using laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS), while homogeneity on the micrometer scale was assessed through ?CT. A series of standards was prepared by fusion of pure HAp with Li(2)B(4)O(7) in a concentration range between 0.12 and 0.74 g cm(-3). Furthermore, pressed and sintered pellets of pure HAp were prepared to extend the calibration range towards densities of up to 3.05 g cm(-3). A linear calibration curve was constructed using all individual standard materials and the slope of the curve was in good agreement with calculated absorption coefficients at the effective energy of the ?CT scanner
0003-2654
1040-1045
Schweizer, Susanne
74f92c7d-1d51-4a20-96b2-080eca9a477a
Hattendorf, Bodo
3bff2eb1-361b-4a58-9f72-2d89ec43bda9
Schneider, Philipp
a810f925-4808-44e4-8a4a-a51586f9d7ad
Aeschlimann, Beat
d90cc942-eae5-4ee7-a24f-27e40ba6756b
Gauckler, Ludwig
d704bddd-1ba7-49a6-bf10-dc329a7867a0
Müller, Ralph
f881853a-540f-48f1-bb6d-e0cf1894e036
Günther, Detlef
70fbccee-e6bf-4230-8b62-6746aa6d3e4c
Schweizer, Susanne
74f92c7d-1d51-4a20-96b2-080eca9a477a
Hattendorf, Bodo
3bff2eb1-361b-4a58-9f72-2d89ec43bda9
Schneider, Philipp
a810f925-4808-44e4-8a4a-a51586f9d7ad
Aeschlimann, Beat
d90cc942-eae5-4ee7-a24f-27e40ba6756b
Gauckler, Ludwig
d704bddd-1ba7-49a6-bf10-dc329a7867a0
Müller, Ralph
f881853a-540f-48f1-bb6d-e0cf1894e036
Günther, Detlef
70fbccee-e6bf-4230-8b62-6746aa6d3e4c

Schweizer, Susanne, Hattendorf, Bodo, Schneider, Philipp, Aeschlimann, Beat, Gauckler, Ludwig, Müller, Ralph and Günther, Detlef (2007) Preparation and characterization of calibration standards for bone density determination by micro-computed tomography. Analyst, 132 (10), 1040-1045. (doi:10.1039/b703220j). (PMID:17893808)

Record type: Article

Abstract

Phantoms for the calibration of local bone mineral densities by micro-computed tomography (?CT), consisting of lithium tetraborate (Li(2)B(4)O(7)) with increasing concentrations of hydroxyapatite [HAp, Ca(10)(PO(4))(6)(OH)(2)] have been prepared and characterized for homogeneity. Large-scale homogeneity and concentration of HAp in the phantom materials was determined using laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS), while homogeneity on the micrometer scale was assessed through ?CT. A series of standards was prepared by fusion of pure HAp with Li(2)B(4)O(7) in a concentration range between 0.12 and 0.74 g cm(-3). Furthermore, pressed and sintered pellets of pure HAp were prepared to extend the calibration range towards densities of up to 3.05 g cm(-3). A linear calibration curve was constructed using all individual standard materials and the slope of the curve was in good agreement with calculated absorption coefficients at the effective energy of the ?CT scanner

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Published date: 7 August 2007
Organisations: Faculty of Engineering and the Environment

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Local EPrints ID: 361060
URI: http://eprints.soton.ac.uk/id/eprint/361060
ISSN: 0003-2654
PURE UUID: 173fce79-ad0a-48b0-a16a-7e69a013a37c
ORCID for Philipp Schneider: ORCID iD orcid.org/0000-0001-7499-3576

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Date deposited: 13 Jan 2014 11:27
Last modified: 10 Sep 2019 00:35

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Contributors

Author: Susanne Schweizer
Author: Bodo Hattendorf
Author: Beat Aeschlimann
Author: Ludwig Gauckler
Author: Ralph Müller
Author: Detlef Günther

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