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Three-dimensional morphometry of strained bovine periodontal ligament using synchrotron radiation-based tomography

Three-dimensional morphometry of strained bovine periodontal ligament using synchrotron radiation-based tomography
Three-dimensional morphometry of strained bovine periodontal ligament using synchrotron radiation-based tomography
The periodontal ligament (PDL) is a highly vascularized soft connective tissue. Previous studies suggest that the viscous component of the mechanical response may be explained by the deformation-induced collapse and expansion of internal voids (i.e. chiefly blood vessels) interacting with liquids (i.e. blood and interstitial fluids) flowing through the pores. In the present work we propose a methodology by means of which the morphology of the PDL vascular plexus can be monitored at different levels of compressive and tensile strains. To this end, 4-mm-diameter cylindrical specimens, comprising layers of bone, PDL and dentin covered by cementum, were strained at stretch ratios ranging from lambda = 0.6 to lambda = 1.4 and scanned using synchrotron radiation-based computer tomography. It was concluded that: (1) the PDL vascular network is layered in two distinct planes of blood vessels (BVs): an inner layer (close to the tooth), in which the BVs run in apico-coronal direction, and an outer layer (close to the alveolar bone), in which the BVs distribution is more diffuse; (2) during tension and compression, the porosity tissue is kept fairly constant; (3) mechanical straining induces important changes in BV diameters, possibly modifying the permeability of the PDL and thus contributing to the viscous component of the viscoelastic response observed under compressive forces
0021-8782
126-134
Bergomi, Marzio
6f4aa5aa-352b-435b-b394-575db0f5854e
Cugnoni, Joël
83573d50-0983-4471-a76b-be1e4212d728
Anselm Wiskott, H.W.
d454c209-cdff-46bf-bdfe-15bbb852983f
Schneider, Philipp
a810f925-4808-44e4-8a4a-a51586f9d7ad
Stampanoni, Marco
bfedb3b0-01e8-4e1b-9163-41295b4ceeb1
Botsis, John
e456b563-8078-4fcb-8989-efa09812bab3
Belser, Urs C.
3cc2645c-c3ad-41bc-add8-b9a4bdcb3fb7
Bergomi, Marzio
6f4aa5aa-352b-435b-b394-575db0f5854e
Cugnoni, Joël
83573d50-0983-4471-a76b-be1e4212d728
Anselm Wiskott, H.W.
d454c209-cdff-46bf-bdfe-15bbb852983f
Schneider, Philipp
a810f925-4808-44e4-8a4a-a51586f9d7ad
Stampanoni, Marco
bfedb3b0-01e8-4e1b-9163-41295b4ceeb1
Botsis, John
e456b563-8078-4fcb-8989-efa09812bab3
Belser, Urs C.
3cc2645c-c3ad-41bc-add8-b9a4bdcb3fb7

Bergomi, Marzio, Cugnoni, Joël, Anselm Wiskott, H.W., Schneider, Philipp, Stampanoni, Marco, Botsis, John and Belser, Urs C. (2010) Three-dimensional morphometry of strained bovine periodontal ligament using synchrotron radiation-based tomography. Journal of Anatomy, 217 (2), 126-134. (doi:10.1111/j.1469-7580.2010.01250.x). (PMID:20557399)

Record type: Article

Abstract

The periodontal ligament (PDL) is a highly vascularized soft connective tissue. Previous studies suggest that the viscous component of the mechanical response may be explained by the deformation-induced collapse and expansion of internal voids (i.e. chiefly blood vessels) interacting with liquids (i.e. blood and interstitial fluids) flowing through the pores. In the present work we propose a methodology by means of which the morphology of the PDL vascular plexus can be monitored at different levels of compressive and tensile strains. To this end, 4-mm-diameter cylindrical specimens, comprising layers of bone, PDL and dentin covered by cementum, were strained at stretch ratios ranging from lambda = 0.6 to lambda = 1.4 and scanned using synchrotron radiation-based computer tomography. It was concluded that: (1) the PDL vascular network is layered in two distinct planes of blood vessels (BVs): an inner layer (close to the tooth), in which the BVs run in apico-coronal direction, and an outer layer (close to the alveolar bone), in which the BVs distribution is more diffuse; (2) during tension and compression, the porosity tissue is kept fairly constant; (3) mechanical straining induces important changes in BV diameters, possibly modifying the permeability of the PDL and thus contributing to the viscous component of the viscoelastic response observed under compressive forces

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Published date: 14 June 2010
Organisations: Faculty of Engineering and the Environment

Identifiers

Local EPrints ID: 361067
URI: http://eprints.soton.ac.uk/id/eprint/361067
ISSN: 0021-8782
PURE UUID: 8c3bb7a3-25e0-4ed0-bb21-37806ad3a8c6
ORCID for Philipp Schneider: ORCID iD orcid.org/0000-0001-7499-3576

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Date deposited: 13 Jan 2014 11:53
Last modified: 22 Oct 2019 00:35

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Contributors

Author: Marzio Bergomi
Author: Joël Cugnoni
Author: H.W. Anselm Wiskott
Author: Marco Stampanoni
Author: John Botsis
Author: Urs C. Belser

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